Ashley Ross

Characterizing nonlinear heterogeneous sleep trajectories across the menstrual cycle in a transdiagnostic psychiatric population

Anisha Nagpal, Anna Patterson, Ashley Ross, Loran Knol et autres

STUDY OBJECTIVES: Sleep disturbance is closely linked to affective symptoms and suicidal ideation (SI). These symptoms fluctuate across the menstrual cycle; however, menstrual cycle-related sleep variability remains poorly characterized in psychiatric populations. This study examined how subjective and objective sleep fluctuate across …

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Molecular Mechanisms of Menstrual Cycle–Related Suicide Risk: A Selective Review of Promising Candidate Systems

Ashley Ross, Anna M. Patterson, Tory A. Eisenlohr‐Moul

Females of reproductive age experience more suicidal ideation, suicide attempts, and psychiatric hospitalizations than their male counterparts-with high risk during periods of hormonal transitions (e.g., puberty, the menstrual cycle, and pregnancy), suggesting a role for cyclical ovarian hormone fluctuations in suicide risk. …

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Hormonal contraceptive effects on the brain: considering the dual impact of endogenous and exogenous hormone flux

Ashley Ross, Tory A. Eisenlohr‐Moul

Hormonal contraceptives (HCs), including combined estrogen-progestin oral contraceptives (COCs), are used by millions worldwide for reasons extending beyond contraception, such as managing acne, endometriosis, and premenstrual dysphoric disorder (PMDD). While research confirms that both endogenous ovarian hormones (E2, P4) and synthetic hormones …

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Implementation of a Clinical Decision Support Platform for the Efficient Liberation and Assessment of Feeding and Nutritional Data in a Tertiary Neonatal Intensive Care Unit

T. Jantzen, David R. Genetti, Aamir A. Nayeem, Ashley Ross et autres

Hospitals collect vast amounts of discrete patient data points, such as diagnoses, demographic characteristics, growth measures, and laboratory findings, all of which are stored in the electronic medical record (EMR). The early promise of using the EMR to support research and provide …

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Implementing a Weaning Protocol for Noninvasive Respiratory Support in Neonates Decreases Overuse and , Length of Stay

David N. Matlock, Sarah Perez, Heather A Borchert, Betty Proffitt et autres

BACKGROUND: As part of efforts to decrease length of hospital stay, a protocol for weaning noninvasive respiratory support was implemented using quality improvement methodology. The objective of this study was to determine whether protocol implementation decreased the time to wean to no …

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A Comparison of Two Ventilators Using Volume Guarantee Modes for Ventilation of the Neonate Using a Lung Model

Kelly Reilly, Ashley Ross, Celine Brown, Ryan Forbush

Background:Volume guarantee modes (VG) are used with increasing frequency for the neonatal population in an attempt to minimize lung injury and hypocarbia due to unintentional hyperventilation. Ventilator manufacturers utilize different proximal flow sensor technology and software to achieve VG, and investigation of …

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Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants

Jacqueline G. Gerhart, Kevin Watt, Andrea N. Edginton, Kelly C. Wade et autres

Fluconazole is used to treat hematogenous Candida meningoencephalitis in preterm and term infants. To characterize plasma and central nervous system exposure, an adult fluconazole physiologically-based pharmacokinetic (PBPK) model was scaled to infants, accounting for age dependencies in glomerular filtration and metabolism. The …

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Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants

Julie Autmizguine, P. Brian Smith, Kristi Prather, Catherine M. Bendel et autres

Objectives: Extremely premature infants are at high risk of developing invasive candidiasis; fluconazole prophylaxis is safe and effective for reducing invasive candidiasis in this population but further study is needed. We sought to better understand the effect of prophylactic fluconazole on a …

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Necrotizing Enterocolitis in Infants with Hypoplastic Left Heart Syndrome Following Stage 1 Palliation or Heart Transplant

Nahed O. ElHassan, Xinyu Tang, Jeffrey M. Gossett, Dala Zakaria et autres

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Smooth Implementation of Critical Congenital Heart Defect Screening in a Newborn Nursery

Jennifer Purvis Andrews, Ashley Ross, Mary Ann Salazar, Neil Andrew Tracy et autres

In January of 2012, University of Arkansas for Medical Sciences began implementation of a critical congenital heart disease screening program to identify newborns with structural heart defects. The screening used motion tolerant pulse oximeters in direct sequence to measure the oxygen levels …

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Population Pharmacokinetics of Piperacillin Using Scavenged Samples From Preterm Infants

Michael Cohen‐Wolkowiez, Daniel K. Benjamin, Ashley Ross, Laura P. James et autres

OBJECTIVES: Piperacillin is often used in preterm infants for intra-abdominal infections; however, dosing has been derived from small single-center studies excluding extremely preterm infants at a highest risk for these infections. We evaluated the population pharmacokinetics (PK) of piperacillin using targeted sparse …

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Population Pharmacokinetics of Metronidazole Evaluated Using Scavenged Samples from Preterm Infants

Michael Cohen‐Wolkowiez, Danièle Ouellet, P. Brian Smith, Laura P. James et autres

Pharmacokinetic (PK) studies in preterm infants are rarely conducted due to the research challenges posed by this population. To overcome these challenges, minimal-risk methods such as scavenged sampling can be used to evaluate the PK of commonly used drugs in this population. …

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