Carles Lerín

Predictive epigenetic biomarkers of successful weight-loss intervention in pre-pubertal children with obesity

Flavio Palmieri, Pol Castellano‐Escuder, Marcela Parra-Vargas, María Jesús Leal-Witt et autres

Childhood obesity represents a major public health challenge, increasing long-term risks such as type 2 diabetes and cardiovascular disease. Lifestyle interventions in prepubertal children are often more effective, but individual responses can vary, highlighting the need for predictive biomarkers to personalize treatment. …

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Sex differences in executive functions in children with obesity

Lutzi Castaño, Cristina Sánchez Castañeda, Sandra Chanraud, Xavier Caldú et autres

Obesity has been associated with executive functions (EF) impairments in both adults and children. Independent of obesity, age and sex have been associated with EF. Whether EF differ by sex in pediatric obesity remains understudied. The study investigated sex-dependent differences in working …

Sex differences in executive functions in children with obesity

Sandra Chanraud, Sylvie Berthoz, Marta Ramon-Krauel, María Ángeles Jurado et autres

Obesity has been associated with executive functions (EF) impairments in both adults and children. Independent of obesity, age and sex have been associated with EF. Whether EF differ by sex in pediatric obesity remains understudied. The study investigated sex-dependent differences in working …

Developmental versus diet-induced obesity: similar fat expansion, divergent molecular fingerprints in adipocyte progenitors

Marcela Parra-Vargas, Marta Ramon‐Krauel, Marta Mourin-Fernandez, Tania P. Sánchez-Murguía et autres

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Editorial: Tissue crosstalk in obesity and diabetes: a focus on skeletal muscle

Ana Luísa De Sousa‐Coelho, M. Dulce Estêvão, Mary‐Elizabeth Patti, Carles Lerín

This collection aimed to shed light onto the complex tissue crosstalk underlying metabolic diseases, specifically obesity and type 2 diabetes (T2D). It highlights the latest scientific evidence exploring such interactions among diNerent tissues, with a specific focus on the role of skeletal …

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Transgenerational inheritance of hepatic steatosis in mice: sperm methylome is largely reprogrammed and inherited but does not globally influence liver transcriptome

Sílvia Ribó, Marta Ramon‐Krauel, Josep M Marimon-Escude, Florence Busato et autres

Nutritional challenges and obesity can contribute to the transmission of metabolic diseases through epigenetic mechanisms. Among them, DNA methylation stands out as a potential carrier of information because germline cytosine methylation responds to environmental factors and can be transmitted across generations. Yet, …

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Comprehensive Targeted and Quantitative Profiling of the Human Milk Metabolome: Impact of Delivery Mode, Breastfeeding Practices, and Maternal Diet

Joaquim Calvo‐Lerma, Raúl Cabrera‐Rubio, Carles Lerín, Sónia González et autres

SCOPE: Human milk (HM) is rich in bioactive compounds and essential nutrients. While research has focused on lipids, minerals, immune markers, microbiota, and oligosaccharides, specific metabolites are less studied. This study uses targeted metabolomics to identify and quantify metabolites in HM and …

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Assessment of SARS-CoV-2 neutralizing antibody titers in breastmilk from convalescent and vaccinated mothers

Christine Bäuerl, João Zulaica, Luciana Rusu, Alicia Rodríguez-Moreno et autres

Breastmilk contains antibodies that could protect breastfed infants from infections. In this work, we examined if antibodies in breastmilk could neutralize SARS-CoV-2 in 84 breastmilk samples from women that were either vaccinated (Comirnaty, mRNA-1273, or ChAdOx1), infected with SARS-CoV-2, or both infected …

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Circulating progranulin in human infants: relation to prenatal growth and early postnatal nutrition

Marta Díaz, Alberto Mestres‐Arenas, Carles Lerín, Rubén Cereijo et autres

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Intergenerational Inheritance of Hepatic Steatosis in a Mouse Model of Childhood Obesity: Potential Involvement of Germ-Line microRNAs

Francesc Ribas‐Aulinas, Sílvia Ribó, Eduard Casas, Marta Mourin-Fernandez et autres

Childhood obesity increases the risk of developing metabolic syndrome later in life. Moreover, metabolic dysfunction may be inherited into the following generation through non-genomic mechanisms, with epigenetics as a plausible candidate. The pathways involved in the development of metabolic dysfunction across generations …

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Influence of Executive Function Training on BMI, Food Choice, and Cognition in Children with Obesity: Results from the TOuCH Study

Sandra Luis-Ruiz, Cristina Sánchez‐Castañeda, Maite Garolera, Sara Miserachs-González et autres

BACKGROUND: Children with obesity have a higher risk of future health and psychological problems. Executive functions (EFs) play a key role in successful dietetic and exercise planning; therefore, new treatments aimed at improving EFs may optimize outcomes. OBJECTIVES: This study evaluates the …

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Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine

Carles Lerín, María Carmen Collado, ELVIRA M. ISGANAITIS, Erland Arning et autres

Breastfeeding is the gold standard for early nutrition. Metabolites from the one-carbon metabolism pool are crucial for infant development. The aim of this study is to compare the breast-milk one-carbon metabolic profile to other biofluids where these metabolites are present, including cord …

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