Jonathan Jung

Early liver transplant for alcohol-associated liver disease: Current state and future directions

Jonathan Jung, Bima J. Hasjim, Adrienne Chen, Filza Hussain et autres

Alcohol-associated liver disease (ALD) is a rapidly increasing indication for liver transplantation (LT) globally with a significant rise in transplants for ALD with limited sobriety including patients with alcohol-associated hepatitis (AH). This evolution challenges the older paradigm that mandates prolonged periods of …

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Drivers and implications of lineage-specific cancer-related mutations in human pluripotent and adult stem cells

Jonathan Jung, Nissim Benvenisty

Human pluripotent stem cells (PSCs) are known to harbor mutations in tumor-associated genes, and here we aim to examine the status of adult stem cells (ASCs). We thus identify cancer-related mutations in 18% of about 600 mesenchymal stem cell samples, and in …

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Comparative study of sample storage conditions on gut dysbiosis in peripheral artery disease

Sarbjeet Niraula, Imadh Khan, Jonathan Jung, Spencer L. Stirewalt et autres

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Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice

Peter Kip, Thijs J. Sluiter, Michael R. MacArthur, Ming Tao et autres

Short-term preoperative methionine restriction (MetR) is a promising translatable strategy to mitigate surgical injury response. However, its application to improve post-interventional vascular remodeling remains underexplored. Here we find that MetR protects from arterial intimal hyperplasia in a focal stenosis model and pathologic …

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Abstract 2034: Gut Microbial Markers Associated With Clinical Features Of Peripheral Artery Disease

Sarbjeet Niraula, Spencer L. Stirewalt, Jonathan Jung, Megan Alagna et autres

Introduction: The human gut microbiome and microbe-derived metabolites are known to be associated with cardiovascular disease. However, their associations with lower extremity peripheral artery disease (PAD) are not well understood. The goal of this study is to identify specific gut microbial markers …

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Abstract 1156: Akkermansia (Strain BAA835) And The Microbial ADP-heptose Pathway Are Associated With Reduced Neointimal Hyperplasia After Arterial Injury

Karen J. Ho, Sarbjeet Niraula, Vivek Pamulapati, Jonathan Jung et autres

Introduction: Despite advances in surgical therapy for atherosclerosis, up to 50% of procedures such as balloon angioplasty, stenting, and bypass fail due to restenosis from neointimal hyperplasia, a cell proliferative process potentiated by inflammation. We hypothesized that neointimal hyperplasia is associated with …

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High prevalence of acquired cancer-related mutations in 146 human pluripotent stem cell lines and their differentiated derivatives

Elyad Lezmi, Jonathan Jung, Nissim Benvenisty

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Gut Microbial Markers Associated With Clinical Features of Peripheral Artery Disease

Sarbjeet Niraula, Spencer L. Stirewalt, Jonathan Jung, Megan Alagna et autres

The human gut microbiome and microbe-derived metabolites are known to be associated with cardiovascular disease. However, their associations with lower extremity peripheral artery disease (PAD) are not well-understood. The goal of this study is to identify specific gut microbial markers associated with …

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Akkermansia (Strain BAA835) and the Microbial ADP-Heptose Pathway Are Associated With Reduced Neointimal Hyperplasia After Arterial Injury

Karen J. Ho, Sarbjeet Niraula, Vivek Pamulapati, Jonathan Jung et autres

Despite advances in surgical therapy for atherosclerosis, up to 50% of procedures such as balloon angioplasty, stenting, and bypass fail due to restenosis from neointimal hyperplasia, a cell proliferative process potentiated by inflammation. We hypothesized that neointimal hyperplasia is associated with a …

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Short-term Pre-operative Methionine Restriction Induces Browning of Perivascular Adipose Tissue and Improves Vein Graft Remodeling in Mice

Peter Kip, Thijs J. Sluiter, Michael R. MacArthur, Ming Tao et autres

Abstract Short-term preoperative methionine restriction (MetR) shows promise as a translatable strategy to modulate the body’s response to surgical injury. Its application, however, to improve post-interventional vascular remodeling remains underexplored. Here, we find that MetR protects from arterial intimal hyperplasia in a …

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Abstract 596: Microbe-derived Butyrate Activation Of Free Fatty Acid Receptor-3 Reduces Neointimal Hyperplasia After Arterial Injury By Regulating Immune Response Transcription Networks In Endothelial Cells

Jonathan Jung, Sarbjeet Niraula, James Du, Vivek Pamulapati et autres

Introduction: Microbe-derived butyrate has been shown to reduce neointimal hyperplasia after transluminal arterial injury, an effect that is dependent on free fatty acid receptor-3 (FFAR3). However, the mechanism by which FFAR3 affects the endothelial response to injury is not known. We hypothesize …

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Abstract 137: Identification Of Human Gut Microbial Markers In Patients With Peripheral Artery Disease Using Different Sample Preservation Methods

Sarbjeet Niraula, Spencer L. Stirewalt, Jonathan Jung, Jae Woo Jang et autres

Introduction: The gut microbiome is associated with cardiovascular diseases, but there is a paucity of microbial markers associated specifically with peripheral artery disease (PAD). We sought to identify gut microbial markers associated with PAD and to evaluate different sample preservation methods for …

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