Anna Maassen

SWI/SNF-type complexes–transcription factor interplay: a key regulatory interaction

Anna Maassen, Jarosław Steciuk, Magdalena Wilga, Jakub Szurmak et autres

ATP-dependent switch/sucrose nonfermenting-type chromatin remodeling complexes (SWI/SNF CRCs) are multiprotein machineries altering chromatin structure, thus controlling the accessibility of genomic DNA to various regulatory proteins including transcription factors (TFs). SWI/SNF CRCs are highly evolutionarily conserved among eukaryotes. There are three main subtypes …

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A non‐canonical function of Arabidopsis ERECTA proteins and a role of the SWI3B subunit of the SWI / SNF chromatin remodeling complex in gibberellin signaling

Elżbieta Sarnowska, Szymon Kubala, Pawel Cwiek, Sebastian Sacharowski et autres

The Arabidopsis ERECTA family (ERf) of leucine-rich repeat receptor-like kinases (LRR-RLKs) comprising ERECTA (ER), ERECTA-LIKE 1 (ERL1), and ERECTA-LIKE 2 (ERL2) controls epidermal patterning, inflorescence architecture, and stomata development and patterning. These proteins are reported to be plasma membrane associated. Here we …

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The role of alterations in the functioning of epigenetic machinery on thedevelopment and progression of clear cell renal cell carcinoma

Magdalena Wilga, Anna Maassen, Maciej Łuba, Jakub Szurmak et autres

Clear cell renal cell carcinoma (ccRCC) is a very aggressive disease, thecause of which is not yet fully understood. Due to high resistance to treatment,resulting in high mortality, it is necessary to develop new, moreeffective targeted therapies based on the study of …

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A Non-Canonical Function of Arabidopsis ERECTA Proteins in Gibberellin Signaling

Elżbieta Sarnowska, Szymon Kubala, Pawel Cwiek, Sebastian Sacharowski et autres

Abstract The Arabidopsis ERECTA family (ERf) of leucine-rich repeat receptor-like kinases (LRR-RLKs), comprising ERECTA (ER), ERECTA-LIKE 1 (ERL1) and ERECTA-LIKE 2 (ERL2), control epidermal patterning, inflorescence architecture, stomata development, and hormonal signaling. Here we show that the er/erl1/erl2 triple mutant exhibits impaired …

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Various forms of HIF ‐1α protein characterize the clear cell renal cell carcinoma cell lines

Monika Swiatek, Iga Jancewicz, Jakkapong Kluebsoongnoen, Renata Zub et autres

Renal cell carcinoma (RCC) represents around 2-3% of all malignancies diagnosed in adult patients. Most frequent (around 70-80% cases) and the most aggressive subtype is clear cell RCC (ccRCC). Mutations in VHL (von Hippel Lindau) gene, characteristic for this cancer type, lead …

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The SWI/SNF ATP-Dependent Chromatin Remodeling Complex in Arabidopsis Responds to Environmental Changes in Temperature-Dependent Manner

Dominika M. Gratkowska-Zmuda, Szymon Kubala, Elżbieta Sarnowska, Pawel Cwiek et autres

SWI/SNF ATP-dependent chromatin remodeling complexes (CRCs) play important roles in the regulation of transcription, cell cycle, DNA replication, repair, and hormone signaling in eukaryotes. The core of SWI/SNF CRCs composed of a SWI2/SNF2 type ATPase, a SNF5 and two of SWI3 subunits …

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Downregulation of BRCA1 and CTCF in clear cell renal cell carcinoma

Janusz A. Siedlecki, Natalia Rusetska, Joanna Szarkowska, Marcin Szymański et autres

Loss of SWI/SNF chromatin remodelling complex is linked to advanced urinary bladder cancer

Michał Szymański, Elżbieta Sarnowska, Anna Ornoch, Natalia Rusetska et autres

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Downregulation of BRCA1 protein in clear cell renal cellular carcinoma

Elżbieta Sarnowska, Natalia Rusetska, Marcin Szymański, Iga Jancewicz et autres

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Evaluation of the role of downregulation of SNF5/INI1 core subunit of SWI/SNF complex in clear cell renal cell carcinoma development.

Elżbieta Sarnowska, Michał Szymański, Natalia Rusetska, Marcin Ligaj et autres

transcript level indicating that the INI1-dependent regulatory feedback loop controlling expression of this gene is affected in ccRCC Moreover, the set of INI1 target genes including i.e. CXCL12/CXCR7/CXCR4 chemokine axis was identified to be affected in ccRCC. In summary, we demonstrated that …

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Effect of Medicago sativa Mhb1gene expression on defense response of Arabidopsis thaliana plants.

Anna Maassen, Jacek Hennig

Besides the previously described nitric oxide-detoxification activity we identified new features of class-1 non-symbiotic hemoglobin from Medicago sativa (Mhb1). Under in vitro conditions, using peroxidase in-gel activity assay, the Mhb1 protein was shown to possess also peroxidase-like activity. Due to this activity, …

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NO‐degradation by alfalfa class 1 hemoglobin (Mhb1): a possible link to PR‐1a gene expression in Mhb1‐overproducing tobacco plants

Csaba Seregélyes, Abir U. Igamberdiev, Anna Maassen, Jacek Hennig et autres

Tobacco plants overproducing alfalfa class 1 hemoglobin (HOT plants) have been shown to have reduced necrotic symptom development. Here, we show that this altered pathogenic response is linked to a significant increase in the nitric oxide (NO)-affected pathogenesis-related (PR-1a) transcript accumulation in …

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