Janusz A. Siedlecki

The human papillomavirus — long studied but still not fully understood

Irena Paczkowska, Janusz A. Siedlecki, Agnieszka Świć, Mariusz Bidziński et autres

Large-scale epidemiological studies have been invaluable in establishing a causal relationship between persistent genital human papillomavirus (HPV) infection and the development of invasive cervical cancer. The human papillomavirus is the most common sexually transmitted viral infection worldwide and is associated with various …

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DMRTA2 supports glioma stem-cell mediated neovascularization in glioblastoma

Marta Maleszewska, Kamil Wojnicki, Jakub Mieczkowski, Sylwia Król et autres

Glioblastoma (GBM) is the most common and lethal brain tumor in adults. Due to its fast proliferation, diffusive growth and therapy resistance survival times are less than two years for patients with IDH-wildtype GBM. GBM is noted for the considerable cellular heterogeneity, …

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Genetyka medyczna i molekularna

Jerzy Bal, Ewa Bartnik, Marta Biedrzycka, Ewa Bocian et autres

Książka prezentuje szeroki zakres wiedzy z zakresu genetyki człowieka i zastosowań biologii molekularnej w medycynie. Przedstawione są w niej ważne działy medycyny, w których istotną rolę odgrywa analiza genomu, dziedziczność jak też kwestie genetycznie uwarunkowanej zmienność osobniczej w konfrontacji ze środowiskiem. Szczególne …

A non‐canonical function of Arabidopsis ERECTA proteins and a role of the SWI3B subunit of the SWI / SNF chromatin remodeling complex in gibberellin signaling

Elżbieta Sarnowska, Szymon Kubala, Pawel Cwiek, Sebastian Sacharowski et autres

The Arabidopsis ERECTA family (ERf) of leucine-rich repeat receptor-like kinases (LRR-RLKs) comprising ERECTA (ER), ERECTA-LIKE 1 (ERL1), and ERECTA-LIKE 2 (ERL2) controls epidermal patterning, inflorescence architecture, and stomata development and patterning. These proteins are reported to be plasma membrane associated. Here we …

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Legend for supplementary Figure S1 from Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST

Agnieszka Woźniak, Piotr Rutkowski, Patrick Schöffski, Isabelle Ray‐Coquard et autres

Legend for supplementary Figure S1

Figure S1 from Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST

Agnieszka Woźniak, Piotr Rutkowski, Patrick Schöffski, Isabelle Ray‐Coquard et autres

Figure S1. Disease free survival grouped according to the presence of KIT ex. 11 mutations: KITdel-inc557/558 vs. other deletions vs. duplications vs. substitutions overall (p<0.0001) (A), in gastric GIST (p<0.0001) (B), non-gastric tumors (p=0.599) (C), and in tumors localized in the stomach, …

Legend for supplementary Figure S1 from Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST

Agnieszka Woźniak, Piotr Rutkowski, Patrick Schöffski, Isabelle Ray‐Coquard et autres

Legend for supplementary Figure S1

Figure S1 from Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST

Agnieszka Woźniak, Piotr Rutkowski, Patrick Schöffski, Isabelle Ray‐Coquard et autres

Figure S1. Disease free survival grouped according to the presence of KIT ex. 11 mutations: KITdel-inc557/558 vs. other deletions vs. duplications vs. substitutions overall (p<0.0001) (A), in gastric GIST (p<0.0001) (B), non-gastric tumors (p=0.599) (C), and in tumors localized in the stomach, …

Data from Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST

Agnieszka Woźniak, Piotr Rutkowski, Patrick Schöffski, Isabelle Ray‐Coquard et autres

Abstract Purpose: Although the mutational status in gastrointestinal stromal tumors (GIST) can predict the response to treatment with tyrosine kinase inhibitors, the role of tumor genotype as a prognostic factor remains controversial. The ConticaGIST study sought to determine the pathologic and molecular …

Data from Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST

Agnieszka Woźniak, Piotr Rutkowski, Patrick Schöffski, Isabelle Ray‐Coquard et autres

Abstract Purpose: Although the mutational status in gastrointestinal stromal tumors (GIST) can predict the response to treatment with tyrosine kinase inhibitors, the role of tumor genotype as a prognostic factor remains controversial. The ConticaGIST study sought to determine the pathologic and molecular …

Possible Mechanisms of Resistance Development to Photodynamic Therapy (PDT) In Vulvar Cancer Cells

Beata Joanna Mossakowska, Anna Fabisiewicz, Barbara Tudek, Janusz A. Siedlecki

Photodynamic therapy (PDT) is a low-invasive treatment method that can be used to treat VIN patients. A photosensitizer (PS) applied to a patient is activated with use of the appropriate wavelength of light, which in an oxygen environment leads to the formation …

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Mechanisms of Resistance to Photodynamic Therapy (PDT) in Vulvar Cancer

Beata Joanna Mossakowska, Somayeh Shahmoradi Ghahe, Dominik Cysewski, Anna Fabisiewicz et autres

Photodynamic therapy (PDT) is a valuable treatment method for vulvar intraepithelial neoplasia (VIN). It allows for the treatment of a multifocal disease with minimal tissue destruction. 5-Aminolevulinic acid (5-ALA) is the most commonly used prodrug, which is converted in the heme pathway …

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