Thibaut Sanchez

The C-type lectin receptor DCIR senses galactose-terminated N-glycans on LRP1 to regulate myeloid cell function

Yoann Rombouts, Benjamin Raymond, Tamara Sneperger, Stella Rousset et autres

fr, nl (code pays fourni par la source)

Moesin controls cell–cell fusion and osteoclast function

Ophélie Dufrançais, Marianna Plozza, Marie Juzans, Arnaud Métais et autres

Cell-cell fusion is an evolutionarily conserved process that is essential for many functions, including the formation of bone-resorbing multinucleated osteoclasts. Osteoclast multinucleation involves dynamic interactions between the actin cytoskeleton and the plasma membrane that are still poorly characterized. We found that moesin, …

fr, us, de, ru, au, ca (code pays fourni par la source)

Drosophila complement-like Mcr acts as a wound-induced inflammatory chemoattractant

Luigi Zechini, Henry Alfred Todd, Thibaut Sanchez, D. Tudor et autres

Sterile tissue injury is accompanied by an acute inflammatory response whereby innate immune cells rapidly migrate to the site of injury guided by pro-inflammatory chemotactic damage signals released at the wound. Understanding this immune response is key to improving human health, and …

gb (code pays fourni par la source)

Roles of Interleukin‐24 in Epithelial Repair: Bridging Injury and Regeneration

Piotr P. Janas, Thibaut Sanchez

Open access via the Wiley agreement

gb (code pays fourni par la source)

Cell Death and Infection: Implications for Host and Microbe

Anna Davey, Thibaut Sanchez, Christopher D. Lucas, Christopher J. Anderson

Cell death is a part of life. Every day, billions of cells undergo programmed cell death within the human body as part of normal tissue turnover and homeostasis. The factors that initiate programmed cell death, the resulting signalling pathways that occur within …

gb (code pays fourni par la source)

Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics

Perrine Verdys, Javier Rey-Barroso, Adeline Girel, Joseph Vermeil et autres

The cellular cortex provides crucial mechanical support and plays critical roles during cell division and migration. The proteins of the ERM family, comprised of ezrin, radixin, and moesin, are central to these processes by linking the plasma membrane to the actin cytoskeleton. …

fr, ca, de (code pays fourni par la source)

Moesin controls cell-cell fusion and osteoclast function

Ophélie Dufrançais, Perrine Verdys, Marianna Plozza, Arnaud Métais et autres

ABSTRACT Cell-cell fusion is an evolutionarily conserved process that is essential for many functions, including fertilisation and the formation of placenta, muscle and osteoclasts, multinucleated cells that are unique in their ability to resorb bone. The mechanisms of osteoclast multinucleation involve dynamic …

fr, us, de, au, ca (code pays fourni par la source)

Author Reply to Peer Reviews of The membrane-actin linkers ezrin, radixin, and moesin are dispensable for macrophage migration and cortex mechanics.

Perrine Verdys, Javier Rey Barroso, Joseph Vermeil, Martin Bergert et autres

fr, de, ca (code pays fourni par la source)

The membrane-actin linkers ezrin, radixin, and moesin are dispensable for macrophage migration and cortex mechanics

Perrine Verdys, Javier Rey Barroso, Joseph Vermeil, Martin Bergert et autres

Abstract The cellular actin cortex provides crucial mechanical support and plays critical roles in numerous functions, including cell division and migration. The proteins of the ERM family, ezrin, radixin, and moesin, are central to these processes by linking the plasma membrane to …

fr, ca, de (code pays fourni par la source)

Tissue Infiltration of Tumor-Associated Macrophages: Towards the Identification of Therapeutic Targets

Thibaut Sanchez, Frédéric Lagarrigue, Véronique Le Cabec

International audience

fr (code pays fourni par la source)

Genetic engineering of Hoxb8-immortalized hematopoietic progenitors – a potent tool to study macrophage tissue migration

Solène Accarias, Thibaut Sanchez, Arnaud Labrousse, Myriam Ben-Neji et autres

ABSTRACT Tumor-associated macrophages (TAMs) are detrimental in most cancers. Controlling their recruitment is thus potentially therapeutic. We previously found that TAMs perform protease-dependent mesenchymal migration in cancer, while macrophages perform amoeboid migration in other tissues. Inhibition of mesenchymal migration correlates with decreased …

fr (code pays fourni par la source)

Genetic engineering of hoxb8 immortalized hematopoietic progenitors: a potent tool to study macrophage tissue migration

Solène Accarias, Thibaut Sanchez, Arnaud Labrousse, Myriam Ben-Neji et autres

Abstract Tumor-associated macrophages (TAM) are detrimental in most cancers. Controlling their recruitment is thus potentially therapeutic. We showed that TAM perform the protease-dependent mesenchymal migration in cancer, while macrophages perform amoeboid migration in other tissues. Inhibition of mesenchymal migration correlates with decreased …

fr (code pays fourni par la source)