Ruwani Wijeyekoon

rs6971 TSPO polymorphism in Parkinson's disease

Bina Patel, Marta Camacho, Jonathan Evans, David P. Breen et autres

Publication status: Published

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Beta-adrenoceptor drugs and progression to Parkinson’s disease milestones in a large pooled incident cohort

Ruwani Wijeyekoon, Marta Camacho, David C. Bäckström, Lars Forsgren et autres

Beta-adrenoceptor-blockers and agonists have been associated with an increased and decreased risk of Parkinson's disease (PD), respectively. We aimed to investigate whether these medications are linked to clinical heterogeneity and progression in PD. Longitudinal data from the Parkinson's Incident Cohorts Collaboration (n …

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The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson’s disease

Roger A. Barker, Nicholas P Lao–Kaim, Natalie Valle Guzman, Dilan S. Athauda et autres

Abstract Transplantation of human fetal ventral mesencephalic tissue in individuals with Parkinson’s disease has yielded clinical benefits but also side effects, such as graft-induced dyskinesias. The open-label TransEuro trial ( NCT01898390 ) was designed to determine whether this approach could be further …

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Validation of a 5‐Year Prognostic Model for Parkinson's Disease

Joana A Ribeiro, Marta Camacho, Kirsten M. Scott, Julia C. Greenland et autres

BACKGROUND: A simple prognostic model was previously developed to predict the probability of recently-diagnosed patients reaching negative outcomes (postural instability, dementia or death) in a 5-year period. OBJECTIVES: To validate this model in an independent cohort and establish utility at later time …

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Neurological disorders associated with COVID-19 in Sri Lanka

Thashi Chang, Ruwani Wijeyekoon, Ajantha Keshavaraj, Udaya K. Ranawaka et autres

BACKGROUND: Neurological manifestations of SARS-CoV-2 infection have been reported from many countries around the world, including the South Asian region. This surveillance study aimed to describe the spectrum of neurological disorders associated with COVID-19 in Sri Lanka. METHODS: COVID-19 patients manifesting neurological …

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B lymphocyte responses in Parkinson’s disease and their possible significance in disease progression

Kirsten M. Scott, Yen Ting Chong, Seoyoung Park, Ruwani Wijeyekoon et autres

Abstract Inflammation contributes to Parkinson’s disease pathogenesis. We hypothesized that B lymphocytes are involved in Parkinson’s disease progression. We measured antibodies to alpha-synuclein and tau in serum from patients with rapid eye movement sleep behaviour disorder (n = 79), early Parkinson’s disease …

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The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features

William James Griffiths, Jonas Abdel‐Khalik, Sarah F. Moore, Ruwani Wijeyekoon et autres

Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson's disease (PD) patients. When adjustments were made for confounding variables of age and sex, 7α,(25R)26-dihydroxycholesterol and a …

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Early constipation predicts faster dementia onset in Parkinson’s disease

Marta Camacho, Angus D. Macleod, Jodi Maple‐Grødem, Jonathan Evans et autres

Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson's Incidence Cohorts Collaboration, composed of incident …

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Differences in the Presentation and Progression of Parkinson's Disease by Sex

Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L. Leonard, Mary B. Makarious et autres

BACKGROUND: Previous studies reported various symptoms of Parkinson's disease (PD) associated with sex. Some were conflicting or confirmed in only one study. OBJECTIVES: We examined sex associations to PD phenotypes cross-sectionally and longitudinally in large-scale data. METHODS: We tested 40 clinical phenotypes, …

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Early constipation predicts faster dementia onset in Parkinson's disease.

Marta Camacho, Angus D. Macleod, Jodi Maple‐Grødem, Jonathan Evans et autres

Abstract: Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s Incidence Cohorts Collaboration, composed of …

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Parkinson’s disease laterality: a 11C-PE2I PET imaging study

Andreas–Antonios Roussakis, Zhou Zeng, Nicholas P Lao–Kaim, Antonio Martín‐Bastida et autres

Abstract Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging …

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Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson's disease

Neil Ramsay, Ole‐Bjørn Tysnes, Caroline H. Williams‐Gray, Lars Forgren et autres

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