Accès ouvert déclaré 2023 article

Neurological disorders associated with COVID-19 in Sri Lanka

Thashi Chang, Ruwani Wijeyekoon, Ajantha Keshavaraj, Udaya K. Ranawaka, Sunethra Senanayake, Pyara Dilani Ratnayake, Bimsara Senanayake, Manjula Chandragomi Caldera, Gamini Pathirana, Darshana Sirisena, Jithangi Wanigasinghe, Saman B. Gunatilake, Saumya Madhri Senanayake, Maricela Caldera, Dhammika Halahakoon, Dimuthu Saraji Wijesekara, S. Bandusena, Harsha Gunasekara, Champika Gunawardhana, Ajini Arasalingam, Achini Mihindukulasooriya Fernando, Damith Sanjaya Liyanage, Ullala Pathiranage Gayan Pathirana, Thrividya Rathnayake, AT Alibhoy, D. N. Weerathunga, Ajith Munasinghe Dissanayake, K. Gooneratne, A. Jayawardana, Thusha Nawasiwatte, Varithamby Thambippillai Rajendiran, Dilini Rathnayake, G. J. Arhivalaky, S. Branavan, M. J. N. Fernando, K. Janarthanan, K.K.G.K.D. Kariyawasam, Nayananjani Karunasena, Dunya Luke, M. K. T. Madhushanka, S. N. H. Nimesha, M. P. Priyacharana, T. D. Ruvanpathirana, D. P. U. T. Samarasiri, Sanjeeva Weerasinghe

3Citations signalées, ce qui n’est pas une note de qualité

7Institutions déclarées

1Pays d’affiliation déclarés

Rattachement africain : lk. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

BACKGROUND: Neurological manifestations of SARS-CoV-2 infection have been reported from many countries around the world, including the South Asian region. This surveillance study aimed to describe the spectrum of neurological disorders associated with COVID-19 in Sri Lanka. METHODS: COVID-19 patients manifesting neurological disorders one week prior and up to six weeks after infection were recruited from all the neurology centres of the government hospitals in Sri Lanka from May 2021 - May 2022. Data was collected using a structured data form that was electronically transmitted to a central repository. All patients were evaluated and managed by a neurologist. Data were analysed using simple descriptive analysis to characterise demographic and disease related variables, and simple comparisons and logistic regression were performed to analyse outcomes and their associations. RESULTS: One hundred and eighty-four patients with neurological manifestations associated with COVID-19 were recruited from all nine provinces in Sri Lanka. Ischaemic stroke (31%) was the commonest neurological manifestation followed by encephalopathy (13.6%), Guillain-Barre syndrome (GBS) (9.2%) and encephalitis (7.6%). Ischaemic stroke, encephalitis and encephalopathy presented within 6 days of onset of COVID-19 symptoms, whereas GBS and myelitis presented up to 10 days post onset while epilepsy and Bell palsy presented up to 20 - 40 days post onset. Haemorrhagic stroke presented either just prior to or at onset, or 10 - 25 days post onset of COVID-19 symptomatic infection. An increased frequency of children presenting with encephalitis and encephalopathy was observed during the Omicron variant predominant period. A poor outcome (no recovery or death) was associated with supplemental oxygen requirement during admission (Odds Ratio: 12.94; p = 0.046). CONCLUSIONS: The spectrum and frequencies of COVID-19 associated neurological disorders in Sri Lanka were similar to that reported from other countries, with strokes and encephalopathy being the commonest. Requiring supplemental oxygen during hospitalisation was associated with a poor outcome.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Neurological disorders associated with COVID-19 in Sri Lanka
Date Crossref: 04/10/2023
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

University of Colombo pays non établi dans la notice
Université ou école supérieure
Jaffna Teaching Hospital pays non établi dans la notice
Établissement de santé
University of Kelaniya pays non établi dans la notice
Université ou école supérieure
National Hospital of Sri Lanka pays non établi dans la notice
Établissement de santé
Lady Ridgeway Hospital for Children pays non établi dans la notice
Établissement de santé
Colombo North Teaching Hospital pays non établi dans la notice
Établissement de santé
University of Sri Jayewardenepura Department of Medicine pays non établi dans la notice
Université ou école supérieure
Faculty of Medicine Department of Clinical Medicine pays non établi dans la notice
Université ou école supérieure
Association of Sri Lankan Neurologists pays non établi dans la notice
Organisation à but non lucratif
Teaching Hospital Jaffna pays non établi dans la notice
Établissement de santé
Teaching Hospital Anuradhapura pays non établi dans la notice
Établissement de santé

University of Colombo, Jaffna Teaching Hospital et University of Kelaniya, avec 8 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesMultiple Sclerosis Research Studies

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