Tiangang Li

Metabolic regulation of gut barrier integrity in IBD: protein, lipid, and carbohydrate pathways

Ying Wang, Yinying Wang, Yuanjie Fu, Junxin Li et autres

Dietary macronutrients—proteins, lipids, and carbohydrates—influence the pathogenesis of inflammatory bowel disease (IBD) through distinct but interconnected metabolic pathways that extend beyond their roles as energy substrates. This narrative review synthesizes current evidence on how each macronutrient class modulates gut microbiota composition, intestinal …

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A Selective Cullin 3 RING E3 Ligase Inhibitor Attenuates Hyperglycemia via Dual Insulin Sensitizing and Insulinotropic Action

LIJIE GU, LEI XIONG, Mohammad Hasan, Yanhong Du et autres

Hyperglycemia is a hallmark of type 2 diabetes and a key pathogenic driver of diabetes complications. Cullin RING E3 ligases (CRLs) are multisubunit E3 ubiquitin ligases that mediate cellular protein turnover. The activity of CRLs requires cullin neddylation, a posttranslational modification that …

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Malignancy risk and contrast-enhanced ultrasound guidance in non-diagnostic biopsies of peripheral lung lesions: a multicenter study

Qi Li, Xueliang Yan, Fang Nie, Tiantian Dong et autres

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A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran et autres

ABSTRACT Liver aging is characterized by chronic inflammation and metabolic dysfunction that contributes to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Necroptosis, a form of inflammatory cell death, is activated in aging livers, and genetic ( Ripk3 -/- or Mlkl …

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Trimester-specific reference values of ultrasound-derived fat fraction and automated point shear-wave elastography for liver assessment in healthy singleton pregnancies

K. Niu, Jingjing Ye, Xiao-Qiang Liu, Tiangang Li et autres

Background: Liver health is critical in pregnancy due to this organ adapting to meet gestational metabolic demands. Although overall function typically remains normal, hormonal and metabolic shifts can alter hepatic structure and complicate assessment. Conventional liver tests and imaging (e.g., ultrasonography and …

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Hepatocyte and adipocyte CDO1-mediated intracellular cysteine catabolism differentially modulates diet-induced obesity and fatty liver in mice

Jianglei Chen, Yung‐Dai Clayton, Yanhong Du, David Matye et autres

Background and Aims: Plasma cysteine has been positively linked to BMI in humans. Consistently, dietary cysteine restriction significantly decreases obesity in mice via mechanisms that are incompletely defined. Cysteine dioxygenase type 1 (CDO1) mediates the major cysteine catabolism pathway and is highly …

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Panax notoginseng saponins suppress the PI3K/AKT pathway to enhance autophagy and apoptosis in pulmonary fibrosis

Jiong Hou, Lei Li, Chun-bin Sun, Tiangang Li et autres

The progressive development of pulmonary fibrosis (PF) is accompanied by an exaggerated inflammatory response and the accumulation of extracellular matrix in the lung parenchyma. Panax notoginseng saponins (PNS) exert promising anti-fibrotic effects involving a cross-talk between autophagy and apoptosis. However, the mechanisms …

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A Gly-β-muricholic acid and FGF15 combination therapy synergistically reduces “humanized” bile acid pool toxicity in cholestasis mice

Mohammad Nazmul Hasan, Huaiwen Wang, Wenyi Luo, Yanhong Du et autres

Hydrophobic bile acid-mediated hepatobiliary injury is a major driver of cholestasis progression. Most anticholestasis treatments being tested clinically are based on a single agent, which does not always sufficiently alleviate bile acid toxicity to slow disease progression. This study investigates a therapeutic …

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Adipose cullin 3 mediates the antiobesity effect of pan neddylation inhibitors

Lijie Gu, Yanhong Du, Mohammad Nazmul Hasan, Yung‐Dai Clayton et autres

Cullin Ring E3 Ligases (CRLs) belong to the largest family of multisubunit ubiquitin E3 ligases. A cullin serves as the scaffold protein that recruits E3 ligases and substrate receptors in a CRL complex, whose activity requires cullin neddylation, a posttranslational modification that …

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Flavonoid Polyphenols as Therapeutic Agents for Fatty Liver Disease: Mechanisms, Microbiome Interactions, and Metabolic Insights

Lei Li, Yanling Jin, Tiangang Li, Bijun Lv et autres

Fatty liver disease (FLD), encompassing non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD), has become a major global health concern, primarily driven by unhealthy diets and lifestyle changes. Recently, flavonoids, which account for approximately 60% of polyphenolic compounds, have …

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Gly-βMCA modulates bile acid metabolism to reduce hepatobiliary injury in Mdr2 KO mice

Mohammad Nazmul Hasan, Huaiwen Wang, Wenyi Luo, Yanhong Du et autres

Gly-βMCA decreases liver injury in female but not male Mdr2 KO mice. Gly-βMCA blocks bile acid absorption to reduce bile acid pool in female Mdr2 KO mice. Gly-βMCA reduces bile acid hydrophobicity by causing T-βMCA enrichment in bile, but this therapeutic benefit …

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Tryptophan Indole Derivatives: Key Players in Type 2 Diabetes Mellitus

Yingli Wu, Tiangang Li, Yi Sun, Liyun Song et autres

Type 2 diabetes mellitus (T2DM) is a complex clinical syndrome characterized by insulin resistance and associated with abnormal amino acid metabolism. Tryptophan is an aromatic dietary amino acid that affects T2DM by regulating glycolipid metabolism and insulin resistance. When tryptophan reaches the …

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