LEI XIONG

A Selective Cullin 3 RING E3 Ligase Inhibitor Attenuates Hyperglycemia via Dual Insulin Sensitizing and Insulinotropic Action

LIJIE GU, LEI XIONG, Mohammad Hasan, Yanhong Du et autres

Hyperglycemia is a hallmark of type 2 diabetes and a key pathogenic driver of diabetes complications. Cullin RING E3 ligases (CRLs) are multisubunit E3 ubiquitin ligases that mediate cellular protein turnover. The activity of CRLs requires cullin neddylation, a posttranslational modification that …

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1146-OR: Dual Insulin-Sensitizing and Insulinotropic Actions of a Selective Cullin 3 Neddylation Inhibitor Attenuate Hyperglycemia

LIJIE GU, LEI XIONG, Mohammad Kamrul Hasan, YANHONG DU et autres

Introduction and Objective: Hyperglycemia is a hallmark of type 2 diabetes (T2D) and a key driver for diabetic complications. Cullin Ring E3 Ligases (CRLs) are the largest family of multi-subunit ubiquitin E3 ligases, and their activation requires cullin neddylation, a process that …