Herman Steen

Modulation of blood pharmacokinetics of 68Ga-labelled nanobody analogues targeting the platelet-derived growth factor receptor beta

Viola Wilson, Sergio Antonio Estrada-Parra, Herman Steen, Joost Caumanns et autres

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Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response

Janette van der Linden, Sanne J. M. Stefens, José María Heredia‐Genestar, Yanto R. Ridwan et autres

Abstract Cardiovascular diseases are the number one cause of death globally. The most important determinant of cardiovascular health is a person's age. Aging results in structural changes and functional decline of the cardiovascular system. DNA damage is an important contributor to the …

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Novel 68Ga-labelled nanobody for imaging of platelet-derived growth factor receptor beta

Irina Velikyan, Viola Wilson, Sergio Antonio Estrada-Parra, Herman Steen et autres

Polyacrylamide gel electrophoresis based method for investigation of metabolic stability of [68Ga]Ga-BOT5035 in vitro and in vivo

Irina Velikyan, Herman Steen, Gunnar Antoni

Detection of Experimental Colorectal Peritoneal Metastases by a Novel PDGFRβ-Targeting Nanobody

Esther Strating, Sjoerd Geert Elias, Guus van Scharrenburg, Kaisa E. Luoto et autres

Peritoneal metastases in colorectal cancer (CRC) belong to Consensus Molecular Subtype 4 (CMS4) and are associated with poor prognosis. Conventional imaging modalities, such as Computed Tomography (CT) and Fluorodeoxyglucose-Positron Emission Tomography (FDG-PET), perform very poorly in the detection of peritoneal metastases. However, …

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Initial results of clinical phase 0 study on [68Ga]Ga-BOT5035/PET for the assessment of fibrosis activity

Irina Velikyan, Paul Runeson, Jonathan Sigfridsson, Fredrik Rorsman et autres

GMP production of [68Ga]Ga-BOT5035 for imaging of liver fibrosis in microdosing phase 0 study

Irina Velikyan, Johan G. Doverfjord, Sergio Estrada, Herman Steen et autres

Early detection of liver fibrosis and monitoring response to treatment crucial for the management of patients are currently not feasible in clinical practice. Platelet derived growth factor receptor β (PDGFR-β) expression is regarded as a potential biomarker to determine the stages of …

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Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Denise M.S. van Marion, Xu Hu, Deli Zhang, Femke Hoogstra‐Berends et autres

Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of …

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HALT & REVERSE: Hsf1 activators lower cardiomyocyt damage; towards a novel approach to REVERSE atrial fibrillation

Eva A.H. Lanters, Denise M.S. van Marion, Charles Kik, Herman Steen et autres

BACKGROUND: Atrial fibrillation is a progressive arrhythmia, the exact mechanism underlying the progressive nature of recurrent AF episodes is still unknown. Recently, it was found that key players of the protein quality control system of the cardiomyocyte, i.e. Heat Shock Proteins, protect …

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The future of atrial fibrillation therapy: intervention on heat shock proteins influencing electropathology is the next in line

Eva A.H. Lanters, Denise M.S. van Marion, Herman Steen, Natasja M. S. de Groot et autres

Atrial fibrillation (AF) is the most common age-related cardiac arrhythmia accounting for one-third of hospitalisations. Treatment of AF is difficult, which is rooted in the progressive nature of electrical and structural remodelling, called electropathology, which makes the atria more vulnerable for AF. …

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Tumor‐targeted intracellular delivery of anticancer drugs through the mannose‐6‐phosphate/insulin‐like growth factor II receptor

Jai Prakash, Leonie Beljaars, Akshay K. Harapanahalli, M. Zeinstra-Smith et autres

Tumor-targeting of anticancer drugs is an interesting approach for the treatment of cancer since chemotherapies possess several adverse effects. In the present study, we propose a novel strategy to deliver anticancer drugs to the tumor cells through the mannose-6-phosphate/insulin-like growth factor receptor …

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Effects of Theophylline on Tolerance to the Bronchoprotective Actions of Salmeterol in Asthmatics In Vivo

David Wing-Shing Cheung, A.M.J. Wever, JAAP A. de GOEIJ, Casper S. de Graaff et autres

Long-term treatment with salmeterol produces tolerance for its protective effects against bronchoconstrictor stimuli in patients with asthma. There is human in vitro evidence that theophylline may prevent beta2-adrenoceptor downregulation. Therefore, we investigated the effect of theophylline on the tolerance to the protective …

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