Casper S. de Graaff

Validation of a visual analogue score ( LRTI‐VAS ) in non‐ CF bronchiectasis

Josje Altenburg, Kim Wortel, Casper S. de Graaff, Tjip S. van der Werf et autres

Abstract Background and Aim Quality of life in patients with non‐cystic fibrosis (non‐CF) bronchiectasis is largely defined by respiratory symptoms. To date, no disease‐specific tool for symptom measurement in this patient group was available. We developed the lower respiratory tract infections – …

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Effect of Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis

Josje Altenburg, Casper S. de Graaff, Ymkje Stienstra, Jacobus H Sloos et autres

IMPORTANCE: Macrolide antibiotics have been shown beneficial in cystic fibrosis (CF) and diffuse panbronchiolitis, and earlier findings also suggest a benefit in non-CF bronchiectasis. OBJECTIVE: To determine the efficacy of macrolide maintenance treatment for adults with non-CF bronchiectasis. DESIGN, SETTING, AND PARTICIPANTS: …

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Immunomodulatory Effects of Macrolide Antibiotics – Part 1: Biological Mechanisms

Josje Altenburg, Casper S. de Graaff, Tjip S. van der Werf, Wim G. Boersma

Macrolide antibiotics are well known for their antibacterial and anti-inflammatory properties. This article provides an overview of the biological mechanisms through which macrolides exert this 'double effect'. Their antibacterial effect consists of the inhibition of bacterial protein synthesis, impaired bacterial biofilm synthesis, …

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Immunomodulatory Effects of Macrolide Antibiotics – Part 2: Advantages and Disadvantages of Long-Term, Low-Dose Macrolide Therapy

Josje Altenburg, Casper S. de Graaff, Tjip S. van der Werf, Wim G. Boersma

The available evidence for long-term, low-dose treatment with 14- and 15-membered ring macrolides in non-cystic fibrosis (CF) bronchiectasis, COPD, chronic sinusitis, and asthma is reviewed with special attention to possible adverse effects and the emergence of resistance during long-term macrolide treatment. Macrolide …

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Efficacy of Corticosteroids in Community-acquired Pneumonia: A Randomized Double-Blinded Clinical Trial

Dominic Snijders, Johannes M. A. Daniels, Casper S. de Graaff, Tjip S. van der Werf et autres

RATIONALE: Some studies have shown a beneficial effect of corticosteroids in patients with community-acquired pneumonia (CAP), possibly by diminishing local and systemic antiinflammatory host response. OBJECTIVES: To assess the efficacy of adjunctive prednisolone treatment in patients hospitalized with CAP. METHODS: Hospitalized patients, …

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Antibiotics in Addition to Systemic Corticosteroids for Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Johannes M. A. Daniels, Dominic Snijders, Casper S. de Graaff, Fer Vlaspolder et autres

RATIONALE: The role of antibiotics in acute exacerbations is controversial and their efficacy when added to systemic corticosteroids is unknown. OBJECTIVES: We conducted a randomized, placebo-controlled trial to determine the effects of doxycycline in addition to corticosteroids on clinical outcome, microbiological outcome, …

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Sputum colour reported by patients is not a reliable marker of the presence of bacteria in acute exacerbations of chronic obstructive pulmonary disease

Johannes M. A. Daniels, Casper S. de Graaff, Fer Vlaspolder, Dominic Snijders et autres

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[Pharyngitis with necrotising pneumonia caused by Arcanobacterium haemolyticum].

Menno M. van der Eerden, Casper S. de Graaff, Willem Boersma, Fer Vlaspolder

A 20-year-old woman developed symptoms of pharyngitis followed by generalised skin rash and pulmonary infiltrates with cavitation. Arcanobacterium haemolyticum was identified in blood culture, which was susceptible to the antibiotics given. After initiating pathogen-directed therapy, the patient recovered completely. A. haemolyticum is …

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Value of intensive diagnostic microbiological investigation in low- and high-risk patients with community-acquired pneumonia

Menno M. van der Eerden, Fer Vlaspolder, Casper S. de Graaff, Theun de Groot et autres

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Prospective evaluation of pneumonia severity index in hospitalised patients with community-acquired pneumonia

Menno M. van der Eerden, Casper S. de Graaff, WILLEM BRONSVELD, H M Jansen et autres

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[Bronchocentric granulomatosis and mycoplasmal pneumonia].

A. Keijzer, Johannes M. A. Daniels, Walentina A. T. Slieker, Wim Timens et autres

A 61-year-old man presented with dyspnoea, chest pain, high fever and rigour. Chest X-ray revealed a combination of alveolar consolidations and abnormal nodular and interstitial markings. His clinical condition deteriorated despite treatment with antibiotics prescribed on a working diagnosis of pneumonia with …

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Evaluation of an algorithm for switching from IV to PO therapy in clinical practice in patients with community-acquired pneumonia

Menno M. van der Eerden, Casper S. de Graaff, Fer Vlaspolder, WILLEM BRONSVELD et autres

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