Sumit Raybardhan

Barriers and facilitators to antimicrobial stewardship in community pharmacy: A systematic review

Shankavi Vigneswaran, Bradley J Langford, Kevin Brown, Nick Daneman et autres

Background: Community pharmacists (CPs) are well-positioned to address the threat of antimicrobial resistance (AMR) by encouraging appropriate antimicrobial use. Understanding the individual and contextual determinants of CPs’ involvement in antimicrobial stewardship (AMS) helps select sustainable strategies. Our objective was to identify and …

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Clinical Outcomes in Adult Patients Receiving Definitive Cefazolin Therapy for Community- Acquired Enterobacterales Bacteremias across Minimum Inhibitory Concentration Breakpoints

Jerry Lam, Russell Forrest, Xena X. Li, Pavani Das et autres

Background: In 2011, the Clinical and Laboratory Standards Institute revised its minimum inhibitory concentration (MIC) breakpoints for systemic cefazolin therapy to address rising antibiotic resistance. The revision was based on pharmacokinetic–pharmacodynamic analysis with limited real-world data. Institutional review led to anticipation of …

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Institutional spillover effects of antimicrobial use on antimicrobial resistance and Clostridioides difficile : a systematic review

Sumit Raybardhan, Bradley J Langford, Russell Forrest, Kevin L. Schwartz et autres

Abstract Objective: To synthesize evidence on institutional spillover effects of antimicrobial use (AMU) on antimicrobial resistance (AMR) and Clostridioides difficile infections on individuals without direct antimicrobial exposure. Design: Systematic review. Methods: Three databases were searched through August 2024 for studies evaluating spillover …

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Antimicrobial stewardship: coming to a community pharmacy near you? A cross-sectional study to understand the perspectives of pharmacists, prescribers and the public

Bradley J. Langford, Shankavi Vigneswaran, Nick Daneman, Rita Ha et autres

This survey of the public, pharmacists, and other healthcare professionals identified factors affecting implementation of antibiotic stewardship in Canadian community pharmacies. Lack of support from non-pharmacist healthcare providers and pharmacy leadership were common barriers. Facilitators included providers' perceived importance of antibiotic stewardship, …

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Peri–Covid-19 Antibiotic Use and Antimicrobial Resistance in Older Adults

Derek R. MacFadden, Colleen J. Maxwell, Dawn M. E. Bowdish, Susan E. Bronskill et autres

BACKGROUND: Antibiotic use during the coronavirus disease 2019 (Covid-19) pandemic was common in the outpatient setting, but was not supported by guidelines. We sought to evaluate the role of this antibiotic use on downstream antibiotic resistance. METHODS: We performed a population-wide cohort …

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Laboratory to Bedside: An Assessment of Clinical Outcomes in Adult Patients Receiving Definitive Cefazolin Therapy in Community-Acquired Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis Bacteremia Across MIC Breakpoints

Jerry Chi Ling Lam, Russell Forrest, Xena X. Li, Pavani Das et autres

Pharmacy residents have the opportunity to complete a research project during their residency training, which provides them with skills on how to conduct and manage a research project. Projects often represent an area of interest and need that has been recognized by …

Real-life implications of prevalence meta-analyses? Doi plots and prediction intervals are the answer – Authors' reply

Jean‐Paul Soucy, Bradley J. Langford, Miranda So, Sumit Raybardhan et autres

has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19.The COVID-19 resource centre is hosted on

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Coronavirus Disease 2019 Vaccination Is Associated With Reduced Outpatient Antibiotic Prescribing in Older Adults With Confirmed Severe Acute Respiratory Syndrome Coronavirus 2: A Population-Wide Cohort Study

Derek R. MacFadden, Colleen J. Maxwell, Dawn M. E. Bowdish, Susan E. Bronskill et autres

BACKGROUND: Antibiotics are frequently prescribed unnecessarily in outpatients with coronavirus disease 2019 (COVID-19). We sought to evaluate factors associated with antibiotic prescribing in outpatients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. METHODS: We performed a population-wide cohort study of outpatients …

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Antimicrobial resistance in patients with COVID-19: a systematic review and meta-analysis

Bradley J. Langford, Miranda So, Marina Simeonova, Valerie Leung et autres

Background Frequent use of antibiotics in patients with COVID-19 threatens to exacerbate antimicrobial resistance. We aimed to establish the prevalence and predictors of bacterial infections and antimicrobial resistance in patients with COVID-19. Methods We did a systematic review and meta-analysis of studies …

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Antibiotic resistance associated with the COVID-19 pandemic: a systematic review and meta-analysis

Bradley J. Langford, Jean‐Paul Soucy, Valerie Leung, Miranda So et autres

BACKGROUND: COVID-19 and antimicrobial resistance (AMR) are two intersecting global public health crises. OBJECTIVE: We aimed to describe the impact of the COVID-19 pandemic on AMR across health care settings. DATA SOURCE: A search was conducted in December 2021 in WHO COVID-19 …

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Antibiotic Resistance associated with the COVID-19 Pandemic: A Rapid Systematic Review

BJ Langford, Jean-Paul R. Soucy, Valerie Leung, Miranda So et autres

Abstract Background COVID-19 and antimicrobial resistance (AMR) are two intersecting global public health crises. Objective We aim to describe the impact of the COVID-19 pandemic on AMR across healthcare settings. Data Source A search was conducted in December 2021 in World Health …

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Predictors and microbiology of respiratory and bloodstream bacterial infection in patients with COVID-19: author's response

Bradley J. Langford, Miranda So, Valerie Leung, Sumit Raybardhan et autres

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