Coronavirus Disease 2019 Vaccination Is Associated With Reduced Outpatient Antibiotic Prescribing in Older Adults With Confirmed Severe Acute Respiratory Syndrome Coronavirus 2: A Population-Wide Cohort Study
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Le résumé fourni par la source
BACKGROUND: Antibiotics are frequently prescribed unnecessarily in outpatients with coronavirus disease 2019 (COVID-19). We sought to evaluate factors associated with antibiotic prescribing in outpatients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. METHODS: We performed a population-wide cohort study of outpatients aged ≥66 years with polymerase chain reaction-confirmed SARS-CoV-2 from 1 January 2020 to 31 December 2021 in Ontario, Canada. We determined rates of antibiotic prescribing within 1 week before (prediagnosis) and 1 week after (postdiagnosis) reporting of the positive SARS-CoV-2 result, compared to a self-controlled period (baseline). We evaluated predictors of prescribing, including a primary-series COVID-19 vaccination, in univariate and multivariable analyses. RESULTS: We identified 13 529 eligible nursing home residents and 50 885 eligible community-dwelling adults with SARS-CoV-2 infection. Of the nursing home and community residents, 3020 (22%) and 6372 (13%), respectively, received at least 1 antibiotic prescription within 1 week of a SARS-CoV-2 positive result. Antibiotic prescribing in nursing home and community residents occurred, respectively, at 15.0 and 10.5 prescriptions per 1000 person-days prediagnosis and 20.9 and 9.8 per 1000 person-days postdiagnosis, higher than the baseline rates of 4.3 and 2.5 prescriptions per 1000 person-days. COVID-19 vaccination was associated with reduced prescribing in nursing home and community residents, with adjusted postdiagnosis incidence rate ratios (95% confidence interval) of 0.7 (0.4-1) and 0.3 (0.3-0.4), respectively. CONCLUSIONS: Antibiotic prescribing was high and with little or no decline following SARS-CoV-2 diagnosis but was reduced in COVID-19-vaccinated individuals, highlighting the importance of vaccination and antibiotic stewardship in older adults with COVID-19.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Coronavirus Disease 2019 Vaccination Is Associated With Reduced Outpatient Antibiotic Prescribing in Older Adults With Confirmed Severe Acute Respiratory Syndrome Coronavirus 2: A Population-Wide Cohort Study
- Date Crossref
- 31/03/2023
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ottawa Hospital Division of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Institute for Clinical Evaluative Sciences pays non établi dans la noticeOrganisation à but non lucratif
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Ottawa Hospital Research Institute pays non établi dans la noticeÉtablissement de santé
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University of Waterloo Schools of Pharmacy and Public Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Regional Municipality of Waterloo pays non établi dans la noticeOrganisme public
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McMaster University pays non établi dans la noticeUniversité ou école supérieure
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University of Toronto Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Public Health Ontario pays non établi dans la noticeÉtablissement de santé
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Unity Health Toronto pays non établi dans la noticeÉtablissement de santé
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Toronto East General Hospital pays non établi dans la noticeÉtablissement de santé
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Sinai Health System pays non établi dans la noticeÉtablissement de santé
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St. Michael's Hospital MAP Centre for Urban Health Solutions pays non établi dans la noticeÉtablissement de santé
Division of Infectious Diseases — Ottawa Hospital, Institute for Clinical Evaluative Sciences et Ottawa Hospital Research Institute, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.