Samal Munidasa

Utility of hyperpolarised xenon-129 magnetic resonance imaging in primary ciliary dyskinesia

Wallace B. Wee, Brandon Zanette, Samal Munidasa, Rachel L. Eddy et autres

Background Managing patients with primary ciliary dyskinesia (PCD) is challenging due to limited therapeutic options and lack of sensitive, disease-specific outcome measures. Hyperpolarised 129-xenon magnetic resonance imaging (Xe MRI) is an emerging imaging modality that quantifies ventilation heterogeneity using the ventilation defect …

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High-Resolution Structural and Functional Lung Assessment of Neonates with Bronchopulmonary Dysplasia using 3D UTE FLORET MRI

Samal Munidasa, Nara S. Higano, Matthew M. Willmering, Alexander M. Matheson et autres

Motivation: Existing 2D multi-slice MRI-based regional ventilation evaluation of neonatal lung diseases has limited through-plane resolution and may miss heterogeneous functional lung abnormalities across the entire lung. Goal(s): To demonstrate the feasibility of 3D ultra echo time (UTE) free-breathing lung MRI for …

Comparison of phase-resolved functional lung (PREFUL) and hyperpolarized 129Xe MRI for longitudinal monitoring of lung function in pediatric cystic fibrosis following elexacaftor/tezacaftor/ivacaftor

Samal Munidasa, Faiyza Alam, Brandon Zanette, Daniel Li et autres

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Multicenter Study of Hyperpolarized Xenon Magnetic Resonance Imaging in Children with Cystic Fibrosis Following Initiation of Cystic Fibrosis Transmembrane Regulator Modulator Therapy (HyPOINT)

Félix Ratjen, Sanja Stanojevic, Samal Munidasa, David J. Roach et autres

Abstract Rationale Elexacaftor/tezacaftor/ivacaftor (ETI) has significantly improved lung function in people with cystic fibrosis (CF), prompting the need for outcome measures that can detect mild disease. In this new era of CFTR (CF transmembrane regulator) modulator therapy, more sensitive endpoints are required …

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Structural and Functional Cardiopulmonary Magnetic Resonance Imaging in Neonates With Bronchopulmonary Dysplasia

Samal Munidasa, Nara S. Higano, R. Zinjal, Matthew M. Willmering et autres

Abstract Rationale: Infants with bronchopulmonary dysplasia (BPD) exhibit broad cardiopulmonary abnormalities. While MRI has been used to quantify structural abnormalities in BPD patients [1], limited studies have evaluated pulmonary function. A newer and accessible MRI technique, phase-resolved functional lung (PREFUL) MRI, has …

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Application of the defect distribution index to functional lung MRI of pediatric cystic fibrosis lung disease and controls

Elisabeth Kieninger, Samal Munidasa, Marion Curdy, Carmen Streibel et autres

Introduction Functional magnetic resonance imaging (MRI) of the lung usually assesses lung impairment as ventilation defect percentage (VDP). However, VDP only reflects the overall burden of disease and does not characterize the regional distribution (i.e. pattern) of defects. The defect distribution index …

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Acceleration of Ventilation-Weighted Free-Breathing Functional 1H MRI in Pediatric Cystic Fibrosis Lung Disease

Samal Munidasa, Brandon Zanette, Marie‐Pier Dumas, Wallace Wee et autres

Motivation: Free-breathing pulmonary MRI acquisitions can be lengthy (i.e. 1-minute per slice) which can prove challenging for imaging pediatric lung diseases. Goal(s): The purpose of this work is to determine if reducing the free-breathing MRI scan time will produce stable ventilation defect …

Assessing 129Xe multi-breath washout MRI response to elexacaftor/tezacaftor/ivacaftor intervention in pediatric CF

Faiyza Alam, Samal Munidasa, Brandon Zanette, Sharon Braganza et autres

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Comparison of 3D UTE free‐breathing lung MRI with hyperpolarized 129Xe MRI in pediatric cystic fibrosis

Samal Munidasa, Brandon Zanette, Marie‐Pier Dumas, Wallace Wee et autres

Abstract Purpose To compare phase‐resolved functional lung (PREFUL) regional ventilation derived from a free breathing 3D UTE radial MRI acquisition to hyperpolarized 129Xe‐MRI (Xe‐MRI), conventional 2D multi‐slice PREFUL MRI, and pulmonary function tests in pediatric cystic fibrosis (CF) lung disease. Methods Free‐breathing …

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Ventilation defect percentage from PREFUL MRI in pediatric primary ciliary dyskinesia

Wallace Wee, Brandon Zanette, Samal Munidasa, Sharon Braganza et autres

Background: Primary ciliary dyskinesia (PCD) is a genetic disease with significant lung morbidity. We previously showed that ventilation defect percentage (VDP; the ratio of non-ventilating lung to thoracic volume) from hyperpolarized 129-Xe MRI (Xe-MRI) is a sensitive and repeatable lung function measure …

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149 Longitudinal evaluation of the responsiveness of hyperpolarized 129Xe multiple-breath washout MRI to elexacaftor/tezacaftor/ivacaftor treatment in pediatric cystic fibrosis

F. Alam, Samal Munidasa, B. Zanette, D. Li et autres

Comparison of 3D Ultra-short Echo Time (UTE) Phase-Resolved Functional Lung (PREFUL) with Hyperpolarized 129Xe MRI in Pediatric Cystic Fibrosis

Samal Munidasa, Brandon Zanette, Marie‐Pier Dumas, Wallace B. Wee et autres

2D phase-resolved functional lung (PREFUL) MRI has been shown to correlate with hyperpolarized Xenon MRI (Xe-MRI) in pediatric Cystic Fibrosis (CF) lung disease but ventilation defects may be missed using the 2D approach. In this study we develop a 3D ultra-short echo …