Noelia A-González

The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease

Carlos Silvestre-Roig, Jose Maria Gonzalez-Granado, Collins Osei-Sarpong, Eva Gricar et autres

Myeloid cells orchestrate vascular inflammation through transcriptional programs that control their maturation, effector function, and survival. While lineage-determining transcription factors establish myeloid identity, our understanding of the transcriptional regulation of myeloid cell behavior in chronic inflammatory contexts remains limited. Nuclear factor-Y (NF-Y) …

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Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis

Amirah Al Jawazneh, Imke Liebold, Stephanie Leyk, Clarissa Lanzloth et autres

The clearance of apoptotic cells by phagocytes is crucial for restoring tissue balance after injury. In autoimmune liver diseases like primary sclerosing cholangitis, cell death is thought to result from accumulation of toxic bile acids within parenchymal cells. Whether, in this context, …

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Active LXR signaling, coupled with elevated mitochondrial and glycolytic metabolism contributes to GM-CSF–induced trained immunity

Yuanyuan Liu, Hamid Arslan, Hannah Hardege, Qian Zhang et autres

Granulocyte-macrophage colony-stimulating factor (GM-CSF) contributes to the host defense and the pathogenesis of inflammatory diseases at least in part through inducing trained immunity (TI), however, the mechanism remains poorly characterized. In this paper, we systematically investigated the associated metabolic and epigenetic reprogramming, …

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Characterization of myocardial infarction by in vivo chemical exchange saturation transfer magnetic resonance imaging using natural D-glucose

Ajay Peddi, Daniel Schache, Chris Lippe, Sai Kiran Reddy Samawar et autres

Cardiac Magnetic Resonance Imaging (CMRI), the gold standard approach for characterizing myocardial infarction (MI), frequently relies on Late Gadolinium Enhancement (LGE) using gadolinium-based contrast agents (GBCA). Whereas novel GBCAs targeting specific molecules have not yet entered clinical practice, chemical exchange saturation transfer …

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Multiomic analysis uncovers a continuous spectrum of differentiation and Wnt-MDK-driven immune evasion in hepatoblastoma

Daniel Münter, Flavia W. de Faria, Mathis Richter, Irene Aranda-Pardos et autres

BACKGROUND & AIMS: Hepatoblastoma is the most common pediatric cancer of the liver, with the majority of cases displaying activating mutations in the Wnt/β-catenin pathway. Understanding the complex milieu of the tumor microenvironment has resulted in promising new therapies for adult cancers, …

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Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages

Imke Liebold, Amirah Al Jawazneh, Christian Casar, Clarissa Lanzloth et autres

Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance. Apoptotic cells are defined by homogeneous characteristics, ignoring their original cell lineage identity. We found that in an interleukin-4 (IL-4)-enriched environment, the sensing of apoptotic neutrophils by macrophages triggered their tissue remodeling …

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Stroke induces disease-specific myeloid cells in the brain parenchyma and pia

Carolin Beuker, David Schafflick, Jan‐Kolja Strecker, Michael Heming et autres

Inflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the brain thus promoting tissue damage after stroke. However, the post-ischemic immune response of border compartments compared to brain parenchyma …

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Inflammatory Monocyte Counts Determine Venous Blood Clot Formation and Resolution

Fatemeh Zare Shahneh, Hans Christian Probst, Sabine C. Wiesmann, Noelia A-González et autres

Background: Monocytes are thought to be involved in venous thrombosis but the role of individual monocyte subpopulations on thrombus formation, clot inflammation, and degradation is an important unresolved issue. We investigate the role of inflammatory Ly6C hi monocytes in deep vein thrombosis …

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Delayed alveolar clearance of nanoparticles through control of coating composition and interaction with lung surfactant protein A

Susana Carregal‐Romero, Hugo Groult, Olga Cañadas, Noelia A-González et autres

The coating composition of nanomedicines is one of the main features in determining the medicines' fate, clearance, and immunoresponse in the body. To highlight the coatings' impact in pulmonary administration, two micellar superparamagnetic iron oxide nanoparticles (SPION) were compared. These nanoparticles are …

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Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

María Crespo, Bárbara González‐Terán, Ivana Nikolić, Alfonso Rojas Mora et autres

Liver metabolism follows diurnal fluctuations through the modulation of molecular clock genes. Disruption of this molecular clock can result in metabolic disease but its potential regulation by immune cells remains unexplored. Here, we demonstrated that in steady state, neutrophils infiltrated the mouse …

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Relevance of angiotensin-(1-7) and its receptor Mas in pneumonia caused by influenza virus and post-influenza pneumococcal infection

Eliza Mathias Melo, Juliana Del Sarto, Juliana P. Vago, Luciana P. Tavares et autres

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Author response: Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

María Crespo, Bárbara González‐Terán, Ivana Nikolić, Alfonso Rojas Mora et autres

Circadian neutrophil infiltration in the liver modulates liver clock-gene expression and daily hepatic metabolism through the secretion of elastase and activation of JNK-FGF21-Bmal1 axis in the hepatocyte.

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