Efstathios Pavlidis

Contribution to Diagnostic Accuracy and Prognostic Significance of MicroRNAs in Thyroid Cancer

Kalliopi E. Stavrati, Efstathios Pavlidis, Alexandra Marneri, Christina Mouratidou et autres

The incidence of thyroid cancer, the most common endocrine malignancy, has increased significantly, underscoring the need for improved diagnostic and prognostic methods. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression and play vital roles in cancer development. In thyroid …

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Sexual Dysfunction with Antipsychotics: Emerging Clues from a Disproportionality Analysis of the World Health Organization VigiBase

Efstathios Pavlidis, Spyridon Siafis, Elena Arzenton, Salvatore Crisafulli et autres

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Revolutionizing Heart Valve Therapy: A Translational Framework for Combining Decellularized Scaffolds With Genetic Modification

Nikolaos P. Tzavellas, Natalia Atzemoglou, Efstathios Pavlidis, Alkinoos Nikolis et autres

Valvular heart disease (VHD) represents a significant global health challenge, affecting over 2.5% of the population and disproportionately impacting older adults due to age-related degenerative processes. Current treatment options-mechanical and bioprosthetic valves-both present substantial limitations that impact patient quality of life and …

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Early-Onset Candidemia in Adult Intensive Care Units

Christina Mouratidou, Kalliopi Tsakiri, Vasiliki Dourliou, Alexandra Marneri et autres

Candidemia is a significant cause of morbidity and mortality among critically ill patients. Early-onset candidemia is characterized by occurring within the first seven days after admission to the Intensive Care Unit and presents several important challenges regarding its management. Risk factors may …

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Current considerations for the management of liver echinococcosis

Efstathios Pavlidis, I. Galanis, T. Pavlidis

Echinococcosis or hydatid disease is induced mainly by Echinococcus granulosus and occasionally by Echinococcus multilocularis (alveolaris) and affects the liver predominantly. Hepatic alveolar echinococcosis is similar to carcinoma in appearance, and without treatment, it can lead to death. Diagnosis is based on …

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Current opinions on the use of prophylactic antibiotics in patients undergoing laparoscopic cholecystectomy

Efstathios Pavlidis, I. Galanis, T. Pavlidis

Inappropriate use of antibiotics leads to microbial resistance. Single-dose antibiotic prophylaxis prior to laparoscopic cholecystectomy is well known for reducing the risk of postoperative infection in high-risk patients despite some conflicting aspects. High-risk patients are those who are older than 70 years, …

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Current considerations for the surgical management of gallbladder adenomas

Efstathios Pavlidis, I. Galanis, T. Pavlidis

Gallbladder adenomas are rare lesions (0.5%) associated with potential malignant transformation, particularly with gallbladder adenomas that are ≥ 1 cm in size. Early detection and management are crucial for preventing lethal carcinoma development. These polyps can often be distinguished from the more …

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New trends in diagnosis and management of gallbladder carcinoma

Efstathios Pavlidis, I. Galanis, T. Pavlidis

Gallbladder (GB) carcinoma, although relatively rare, is the most common biliary tree cholangiocarcinoma with aggressiveness and poor prognosis. It is closely associated with cholelithiasis and long-standing large (> 3 cm) gallstones in up to 90% of cases. The other main predisposing factors …

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Management of infected acute necrotizing pancreatitis

Efstathios Pavlidis, T. Pavlidis

Background: In acute pancreatitis, secondary infection of pancreatic necrosis is a complication that mostly necessitates interventional therapy.A reliable prediction of infected necrotizing pancreatitis would enable an early identification of patients at risk, which however, is not possible yet.Methods: This study aims to …

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Multiple-timescale dynamics, mixed mode oscillations and mixed affective states in a model of bipolar disorder

Efstathios Pavlidis, Fabien Campillo, Albert Goldbeter, Mathieu Desroches

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Prediction factors for ischemia of closed-loop small intestinal obstruction

Efstathios Pavlidis, T. Pavlidis

A closed-loop type of intestinal obstruction leads to ischemic necrosis. There have been indicators that may predict ischemia and its severity, such as biomarkers and computed tomography scans. In addition to the usual inflammation markers, such as white blood count-neutrophil count and …

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Current Aspects on the Management of Perforated Acute Diverticulitis: A Narrative Review

Efstathios Pavlidis, T. Pavlidis

Unhealthy nutritional habits and the current western lifestyle have led to an increased incidence of acute diverticulitis, which mainly affects older patients. However, the disease course in younger patients might be more severe. It has a continued increase in surgical practice, as …

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