Paul Forsythe

Progressive Post-Acute Gut Microbiome Disruption Following SARS‑CoV‑2 Infection in Mice

Ritu Mann‐Nüttel, Natacha S. Ogando, Marie Armbruster, Shivani Mandal et autres

SARS‑CoV‑2 infection is increasingly recognized to produce long‑lasting physiological disturbances that extend beyond the acute phase. The gut microbiome has emerged as a potential contributor to post‑infection outcomes, yet the longitudinal progression of microbial disruption following infection remains poorly defined. Here, we …

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PAR2 signaling shapes microbial and metabolic remodeling along the gut–lung axis

Ritu Mann‐Nüttel, Riya Jindal, Marie Armbruster, Shivani Mandal et autres

Abstract Introduction Protease activated receptor (PAR2) is a prominent sensor of environmental and microbial proteases and may serve as an important interface between the host epithelium and mucosal microbes. However, whether PAR2 helps shape microbial community structure and function at barrier surfaces …

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Limited nesting stress in mice as a model to study neuroimmune relationships in postpartum depression

Marie Armbruster, Ritu Mann‐Nüttel, Shivani Mandal, Karen‐Anne McVey Neufeld et autres

Postpartum depression (PPD) is a mood disorder that affects the ability of mothers to engage with and care for their infants. Stress exposure is known to be a major predisposing factor for PPD, while immune factors such as T regulatory cells (Tregs) …

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Research note: Gentle versus severe feather pecking: effects of synbiotic feed supplementation under chronic stress in laying hens

Nienke van Staaveren, Emily M. Leishman, Gillian Hughes, Anna Lea Nicklas et autres

Feather pecking in laying hens is a complex behavior influenced by stress and the gut microbiota, with severe feather pecking (SFP) posing a major welfare concern and gentle feather pecking (GFP) representing a non-injurious, socially mediated behavior. This study investigated the effects …

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Preference and behavioral responses to synbiotic supplementation via drinking water in laying hens under social stress

Anna R. Naim, Nienke van Staaveren, Emily M. Leishman, Anna Lea Nicklas et autres

Synbiotics (SYN) have the potential to enhance animal health, but their efficacy depends on both biological impact and voluntary intake, particularly under stress, when hydration and gut support are critical. This study presents the first investigation of SYN supplementation delivered exclusively through …

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Airway sensory systems: breathing new life into microbiota-brain communication

Ritu Mann‐Nüttel, Marie Armbruster, Shivani Mandal, Paul Forsythe

The essential role of the lungs in gas exchange necessitates exposure to possible threats from a dynamic external environment. To protect life-critical functions the airways contain multiple systems that monitor the inhaled environment and elicit appropriate defensive responses. As such the airways …

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Distinguishing the causative, correlative and bidirectional roles of the gut microbiota in mental health

Srinivas S. Kamath, Elysia Sokolenko, Scott Richard Clark, Courtney Cross et autres

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Asthma: Biomedical and Psychobiological Perspectives

Thomas Ritz, Melissa A. Rosenkranz, Juan C. Celedón, Paul Wesley Davenport et autres

Substantial knowledge about asthma has accumulated in past decades from biomedical and psychobiological research. This white paper reports on synergistic perspectives for these fields discussed at the first Annual Disease-A-Year Symposium of the American Psychosomatic Society. Progress has been made in identifying …

Therapeutic Value of Lactobacillus gasseri 345A in Chronic Constipation

Stefan Roos, Atti‐La Dahlgren, Yukang Mao, Anton Pallin et autres

BACKGROUND: Chronic constipation is a prevalent, burdensome gastrointestinal disorder whose etiology and pathophysiology remain poorly understood. Differences in the composition of the intestinal microbiota have been shown between constipated patients and healthy people. Data indicate that these microbial differences contribute to the …

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The Perinatal Microbiota-Gut-Brain Axis: Implications for Postpartum Depression

Marie Armbruster, Paul Forsythe

BACKGROUND: Pregnancy and childbirth are accompanied by widespread maternal physiological adaptations and hormonal shifts that have been suggested to result in a period of vulnerability for the development of mood disorders such as postpartum depression (PPD). There is also evidence of peripartum …

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Human Pulmonary Neuroendocrine Cells Respond to House Dust Mite Extract With PAR ‐1 Dependent Release of CGRP

Ritu Mann‐Nüttel, Shivani Mandal, Marie Armbruster, Lakshmi Puttagunta et autres

BACKGROUND: Pulmonary neuroendocrine cells (PNEC) are rare airway epithelial cells that have recently gained attention as potential amplifiers of allergic asthma. However, studying PNEC function in humans has been challenging due to a lack of cell isolation methods, and little is known …

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Human pulmonary neuroendocrine cells respond to House dust mite extract with PAR-1 dependent release of CGRP

Ritu Mann-Nuttel, Shivani Mandal, Marie Armbruster, Lakshmi Puttagunta et autres

Background: Pulmonary neuroendocrine cells (PNEC) are rare airway epithelial cells that have recently gained attention as potential amplifiers of allergic asthma. However, studying PNEC function in humans has been challenging due to a lack of cell isolation methods and little is known …

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