Maria Krestyaninova

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

Johann S. Hawe, Rory Wilson, Katharina Schmid, Li Zhou et autres

de, gb, sg, ca, fi, ch, us (code pays fourni par la source)

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research

Ola Spjuth, Maria Krestyaninova, Janna Hastings, Huei-Yi Shen et autres

A wealth of biospecimen samples are stored in modern globally distributed biobanks. Biomedical researchers worldwide need to be able to combine the available resources to improve the power of large-scale studies. A prerequisite for this effort is to be able to search …

se, gb, ch, fi, de, no, ee, ca, lv, at, nl (code pays fourni par la source)

Erratum: Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Fiona Allum, Xiaojian Shao, Frédéric Guénard, Marie-Michelle Simon et autres

Nature Communications 6: Article number: 7211 (2015); Published 29 May 2015; Updated 29 July 2015. The HTML version of this Article incorrectly included all members of The Multiple Tissue Human Expression Resource Consortium in the list of authors. This error has now …

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Fiona Allum, Xiaojian Shao, Frédéric Guénard, Marie-Michelle Simon et autres

Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted arrays or enrichment methodologies preferentially covering CpG-dense regions, to characterize sufficiently large samples. To overcome this limitation, we present here a new customizable, cost-effective approach, methylC-capture sequencing (MCC-Seq), for sequencing functional …

ca, us, se, gb, ch (code pays fourni par la source)

Differential methylation of the TRPA1 promoter in pain sensitivity

Jordana T. Bell, A. Katrina Loomis, Lee M Butcher, Fei Gao et autres

Chronic pain is a global public health problem, but the underlying molecular mechanisms are not fully understood. Here we examine genome-wide DNA methylation, first in 50 identical twins discordant for heat pain sensitivity and then in 50 further unrelated individuals. Whole-blood DNA …

gb, us, cn, ch, sa, gr, mo, dk (code pays fourni par la source)

Data Integration between Swedish National Clinical Health Registries and Biobanks Using an Availability System

Ola Spjuth, Jani Heikkinen, Jan‐Eric Litton, Juni Palmgren et autres

se, fi, ch (code pays fourni par la source)

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

Elin Grundberg, Eshwar Meduri, Johanna K. Sandling, Åsa K. Hedman et autres

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

Elin Grundberg, Eshwar Meduri, Johanna K. Sandling, Åsa K. Hedman et autres

Epigenetic modifications such as DNA methylation play a key role in gene regulation and disease susceptibility. However, little is known about the genome-wide frequency, localization, and function of methylation variation and how it is regulated by genetic and environmental factors. We utilized …

gb, se, ch, ca (code pays fourni par la source)

PPISURV: a novel bioinformatics tool for uncovering the hidden role of specific genes in cancer survival outcome

A V Antonov, Maria Krestyaninova, Richard A. Knight, Igor Rodchenkov et autres

gb, fi, ca, it (code pays fourni par la source)

Mapping cis- and trans-regulatory effects across multiple tissues in twins

Elin Grundberg, Kerrin S. Small, Åsa K. Hedman, Alexandra C. Nica et autres

gb, ch, is, us (code pays fourni par la source)

Biobank Metaportal to Enhance Collaborative Research: sail.simbioms.org

Maria Krestyaninova, Ola Spjuth, Janna Hastings, Jörn Dietrich et autres

In order to identify new ways to prevent, diagnose and treat diseases, biobanks systematically collect samples of human tissues and population-wide data on health and lifestyle. Efficient access to population biobank data and to biomaterial is crucial for development and marketing of …

fi, se, gb (code pays fourni par la source)

Services Design in a Collaborative Network for Multidisciplinary Research Projects

Maria Krestyaninova, Yulia Tammisto

Providing information management services for multi-disciplinary research projects presents scientific, technological and communication challenges: constant change of themes and objects of scientific studies, entangled privacy and ownership requirements along with rapidly evolving methods of analysis and ways to look at data call …

fi, ch (code pays fourni par la source)