Isabelle Halphen

Value of biomarkers for predicting immunoglobulin A vasculitis nephritis outcome in an adult prospective cohort

Laureline Berthelot, Agnès Jamin, Denis Viglietti, Jonathan Chemouny et autres

Background: Henoch-Schönlein purpura, more recently renamed immunoglobulin A vasculitis (IgAV), is a systemic vasculitis characterized by IgA deposits. The current markers used to assess IgAV inaccurately evaluate the risk of nephritis occurrence and its long-term outcomes. The current study assessed biomarkers of …

fr, us, cn, it, be (code pays fourni par la source)

Severe Nocturnal and Postexercise Hypoxia in Children and Adolescents with Sickle Cell Disease

Isabelle Halphen, Caroline Elie, Valentine A.M. Brousse, Muriel Le Bourgeois et autres

Hypoxia is a common feature in children with sickle cell disease (SCD) that is inconsistently associated with painful crises and acute chest syndrome. To assess the prevalence and risk factors of hypoxia, we recorded daytime, nocturnal, and postexercise pulse oximetry (SpO2) values …

fr (code pays fourni par la source)

Children with Sickle Cell Anemia Experience Severe Oxygen Desaturation During Night and After Six-Minute Walk Distance Test

Isabelle Halphen, Caroline Elie, Valentine A.M. Brousse, Muriel Le Bourgeois et autres

Abstract Abstract 4766 Background: Respiratory complications are the first causes of death among adult patients with sickle cell anemia (SCA). Finding risk factors for children is important. We study clinical, biological, respiratory and heart parameters, as well as exercise and sleep oxygen …

fr (code pays fourni par la source)

Thrombotic Microangiopathy and Purtscher-like Retinopathy as a Rare Presentation of Juvenile Dermatomyositis

Brigitte Bader‐Meunier, Dominique Monnet, Christine Barnérias, Isabelle Halphen et autres

Juvenile dermatomyositis is a rare systemic vasculopathy that may sometimes present with acute complications. We report here the case of a 7-year-old boy with severe dermatomyositis associated with thrombocytopenia and blurry vision. The presence of schistocytosis and the secondary occurrence of hemolytic …

us, fr (code pays fourni par la source)

Matrix Metalloproteinase Gene Polymorphisms and Bronchopulmonary Dysplasia: Identification of MMP16 as a New Player in Lung Development

Alice Hadchouel, Fabrice Decobert, Marie‐Laure Franco‐Montoya, Isabelle Halphen et autres

BACKGROUND: Alveolarization requires coordinated extracellular matrix remodeling, a process in which matrix metalloproteinases (MMPs) play an important role. We postulated that polymorphisms in MMP genes might affect MMP function in preterm lungs and thus influence the risk of bronchopulmonary dysplasia (BPD). METHODS …

fr (code pays fourni par la source)

Polymorphisme du gène MMP-2 et risque de dysplasie bronchopulmonaire chez le prématuré né à moins de 28 SA

Isabelle Halphen

fr (code pays fourni par la source)

Polymorphisme du gène MMP-2 et risque de dysplasie bronchopulmonaire chez le prématuré né à moins de 28 SA

Isabelle Halphen, Claude Danan, Marie‐Laure Franco‐Montoya, Olivier Boucherat et autres

fr (code pays fourni par la source)