Erik Maronde

Association of Time of Day With Functional Outcome in Intracerebral Hemorrhage

Franziska Lieschke, Eng H. Lo, Emiri T. Mandeville, Christian Foerch et autres

BACKGROUND: The timing of ischemic stroke and intracerebral hemorrhage (ICH) onsets follow distinct daily patterns, but it remains unclear whether these patterns influence ICH outcomes. METHODS: Consecutive data were obtained from the prospective stroke inpatient quality assurance registry of Hesse, Germany from …

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Time-of-day variation affects onset but not hematoma size in intracerebral hemorrhage

Franziska Lieschke, Philipp Dorsch, Maximilian Rauch, Mario Balo et autres

Introduction In acute ischemic stroke, the time of day has been shown to influence the progression of the ischemic core, ultimately impacting patient outcomes. For intracerebral hemorrhage (ICH), data on such an impact on ICH severity are conflicting. Our aim was to …

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Loss of Schwann cell’s normal rhythmic core clock gene expression and gain of rhythmic expression of oncogenic driver genes in malignant NF1-associated peripheral nerve sheath tumor

Sandra Leisz, Antonio Pelligrino, Saskia Fritzsche, Merle Wiegers et autres

Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor syndrome caused by pathogenic variants in the NF1 gene. Beside tumor formation, patients often have sleep disturbances, suggesting circadian involvement. Previous NF1 studies have implicated MAPK pathway, cAMP-PKA, calcium signaling, and ALK in …

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PDE Inhibitors and Autophagy Regulators Modulate CRE-Dependent Luciferase Activity in Neuronal Cells from the Mouse Suprachiasmatic Nucleus

Erik Maronde, Abdelhaq Rami

BACKGROUND: Signaling pathways like those depending on cAMP/PKA, calcium/calmodulin/CaMK, MEK-1/MAPK or PI3K/Akt have been described to modulate suprachiasmatic nucleus (SCN) neuronal signaling via influencing transcription factors like CREB. Here, we analyzed the effect of cyclic nucleotide phosphodiesterase inhibitors and structurally similar substances …

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Skeletal Phenotyping of Period‐1‐Deficient Melatonin‐Proficient Mice

Olaf Bahlmann, Shahed Taheri, Manuela Spaeth, Katrin Schröder et autres

ABSTRACT In mice, variability in adult bone size and density has been observed among common inbred strains. Also, in the group of genes regulating circadian rhythmicity in mice, so called clock genes, changes in body size and skeletal parameters have been noted …

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Adrenergic Agonists Activate Transcriptional Activity in Immortalized Neuronal Cells From the Mouse Suprachiasmatic Nucleus

Monica Langiu, Faramarz Dehghani, Urszula Hohmann, Philipp Bechstein et autres

The suprachiasmatic nucleus of the hypothalamus (SCN) houses the central circadian oscillator of mammals. The main neurotransmitters produced in the SCN are γ-amino-butyric acid, arginine-vasopressin (AVP), vasoactive intestinal peptide (VIP), pituitary-derived adenylate cyclase-activating peptide (PACAP), prokineticin 2, neuromedin S, and gastrin-releasing peptide …

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Reflections on Several Landmark Advances in Circadian Biology

Sangeeta Chawla, Henrik Oster, Giles E. Duffield, Erik Maronde et autres

Circadian Biology intersects with diverse scientific domains, intricately woven into the fabric of organismal physiology and behavior. The rhythmic orchestration of life by the circadian clock serves as a focal point for researchers across disciplines. This retrospective examination delves into several of …

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Timely Questions Emerging in Chronobiology: The Circadian Clock Keeps on Ticking

Sangeeta Chawla, John Stuart O'Neill, Marina I. Knight, Yuqing He et autres

Chronobiology investigations have revealed much about cellular and physiological clockworks but we are far from having a complete mechanistic understanding of the physiological and ecological implications. Here we present some unresolved questions in circadian biology research as posed by the editorial staff …

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Elucidation of GPR55-Associated Signaling behind THC and LPI Reducing Effects on Ki67-Immunoreactive Nuclei in Patient-Derived Glioblastoma Cells

Marc Richard Kolbe, Tim Hohmann, Urszula Hohmann, Erik Maronde et autres

GPR55 is involved in many physiological and pathological processes. In cancer, GPR55 has been described to show accelerating and decelerating effects in tumor progression resulting from distinct intracellular signaling pathways. GPR55 becomes activated by LPI and various plant-derived, endogenous, and synthetic cannabinoids. …

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Regulation of CRE-Dependent Transcriptional Activity in a Mouse Suprachiasmatic Nucleus Cell Line

Monica Langiu, Philipp Bechstein, Gabriele Spohn, Erik Maronde

We evaluated the signalling framework of immortalized cells from the hypothalamic suprachiasmatic nucleus (SCN) of the mouse. We selected a vasoactive intestinal peptide (VIP)-positive sub-clone of immortalized mouse SCN-cells stably expressing a cAMP-regulated-element (CRE)-luciferase construct named SCNCRE. We characterized these cells in …

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Kommentar zu „Eine neuroanatomische Grundlage für die Elektroakupunktur?“ aus neuroanatomischer Sicht

Erik Maronde

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Analysis of the Human Pineal Proteome by Mass Spectrometry

Mariette Matondo, Guillaume Dumas, Erik Maronde

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