Marinella Pirozzi

Additional file 1 of Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Supplementary Material 1: Supplementary Methods: 1. Microwave-assisted solid phase peptide synthesis of fАβ. 2. Preparation of fluorescent Aβ fibrils. 3. Fluorescence labeled fAβ phagocytosis assay. 4. Immunofluorescence analysis. 5. Morphological analysis of primary microglia. 6. Neuron-microglia cocultures. 7. Time lapse imaging.

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Additional file 1 of Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Supplementary Material 1: Supplementary Methods: 1. Microwave-assisted solid phase peptide synthesis of fАβ. 2. Preparation of fluorescent Aβ fibrils. 3. Fluorescence labeled fAβ phagocytosis assay. 4. Immunofluorescence analysis. 5. Morphological analysis of primary microglia. 6. Neuron-microglia cocultures. 7. Time lapse imaging.

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Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Abstract Background Microglial dysfunction has emerged as a critical factor in the Alzheimer’s Disease (AD), with innate immune dysregulation driving pathological progression. This growing understanding has shifted attention toward the therapeutic modulation of glial response as a means to restore immune balance …

it, fr (code pays fourni par la source)

Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Abstract Background Microglial dysfunction has emerged as a critical factor in the Alzheimer’s Disease (AD), with innate immune dysregulation driving pathological progression. This growing understanding has shifted attention toward the therapeutic modulation of glial response as a means to restore immune balance …

it, fr (code pays fourni par la source)

Additional file 2 of Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Supplementary Material 2: Supplementary Data: Supplementary Figure 1: SULF A did not induce significative cytokine production by primary murine microglia. Supplementary Figure 2: SULF A-treated cells did not exhibit increased uptake of these non-opsonic targets. Supplementary Figure 3: SULF A enhances microglial …

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Additional file 2 of Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Supplementary Material 2: Supplementary Data: Supplementary Figure 1: SULF A did not induce significative cytokine production by primary murine microglia. Supplementary Figure 2: SULF A-treated cells did not exhibit increased uptake of these non-opsonic targets. Supplementary Figure 3: SULF A enhances microglial …

it, fr (code pays fourni par la source)

Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

BACKGROUND: Microglial dysfunction has emerged as a critical factor in the Alzheimer’s Disease (AD), with innate immune dysregulation driving pathological progression. This growing understanding has shifted attention toward the therapeutic modulation of glial response as a means to restore immune balance and …

it, fr (code pays fourni par la source)

The Binding of Concanavalin A to the Surface of Intact and Denuded Sea Urchin Eggs Affects the Fertilization Process by Altering the Structural Dynamics of Actin Filaments

Nunzia Limatola, Marinella Pirozzi, Davide Caramiello, Jong Tai Chun et autres

Sea urchin eggs are surrounded by a network of extracellular matrix, consisting of the jelly coat (JC) and vitelline layer (VL). While the voluminous JC evokes acrosomal reaction in the approaching sperm, the tight VL ensheathing the plasma membrane of the subjacent …

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Second-line therapies of Metastatic Renal Cell Carcinoma (mRCC) after 1st line immune-combinations (ICI-combos) (Meet-URO 33 study)

Davide Bimbatti, Alessandro Acunzo, E. Verzoni, Aimee Di Marco et autres

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri et autres

The secretory pathway is a sophisticated endomembrane machinery designed to transport and deliver proteins and lipids to intracellular organelles and the extracellular space. While the molecular components of the secretory pathway are well understood, less is known about their regulation, especially by …

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Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri et autres

Abstract The secretory pathway is a sophisticated endomembrane machinery designed to transport and deliver proteins and lipids to intracellular organelles and the extracellular space. While the molecular components of the secretory pathway are well understood, less is known about their regulation, especially …

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Cargoes move from cis to trans-Golgi compartments and concentrate in the TGN before exiting

Marinella Pirozzi, Ilenia Agliarulo, Rosaria Di Martino, Vincenzo Manuel Marzullo et autres

The classical models of intra-Golgi transport envision a movement of cargoes from cis- to trans-Golgi, followed by their sorting at the trans-Golgi network (TGN). During this vectorial transport, the cargoes are processed by sequentially acting glycosylation enzymes. A number of studies challenged …

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