Hagar B. Abo-Zalam

Acetyl-11-keto-beta-boswellic acid ameliorates monosodium iodoacetate-induced osteoarthritis in rats: implications of HMGB1/TLR4/NF-κB and Nrf2/HO-1

Hagar B. Abo-Zalam, Abdallah M. Gendy, Bassam Mohamed Ali, Ghada M. Ragab et autres

Introduction: Osteoarthritis (OA) is a prevalent joint disorder marked by chronic inflammation and degradation of cartilage. The shielding effect of 3-O-acetyl-11-keto-β-boswellic acid (AKBA) has been confirmed in many inflammatory disorders. However, the full underlying mechanistic perspective of AKBA against OA remains unexplored. …

Égypte, sa (code pays fourni par la source)

Dapagliflozin Ameliorates Doxorubicin-Induced Chemobrain and Cognitive Abnormalities in Rats: Modulation of AKT/GSK-3β and Wnt/β-Catenin Pathways

Gehad Farouk Abdelhafez, Sylvia A. Boshra, Hagar B. Abo-Zalam, Sara M. Radwan

Cognitive impairments are frequently observed in cancer survivors who received chemotherapy based on doxorubicin (DOX), attributable to oxidative stress, neuroinflammation, and the apoptotic effect of DOX. Dapagliflozin (DAPA) has gained significant attention attributable to its powerful anti-inflammatory, antioxidant, and anti-apoptotic characteristics. The …

Égypte (code pays fourni par la source)

Intranasal delivery of levocetirizine via transethosomal thermosensitive in situ gel: A promising strategy for enhanced nasal absorption and antihistamine action in allergic rhinitis

Asmaa Mohamed, Mohamed A. El-Nabarawi, Mahmoud H. Teaima, Khaled M. Abdel-Haleem et autres

Égypte (code pays fourni par la source)

Parthanatos drives cognitive decline in repeated brain trauma: MSC-derived exosomes as a novel therapeutic strategy

Heba Mohammed Refat M. Selim, Amira A. El-Gazar, Dalaal M. Abdallah, Hagar B. Abo-Zalam et autres

Introduction: Repetitive traumatic brain injury (RTBI) represents a cumulative neurological insult associated with progressive neurodegeneration and limited therapeutic options. In this study, we uniquely evaluate the neuroprotective potential of mesenchymal stem cell (MSC)-derived exosomes in a rat model of RTBI, an area …

sa, Égypte (code pays fourni par la source)

Fabrication of PEGylated elastic bilosomes as a potentially effective transdermal delivery of celecoxib for management of osteoarthritis: In vitro characterization, statistical optimization, Ex vivo and In vivo assessments

Nermin M. Sheta, Mohamed A. El-Nabarawi, Hassan Gamal Mostafa, Hagar B. Abo-Zalam et autres

Égypte (code pays fourni par la source)

Wound Healing Efficacy of Cucurbitaceae Seed Oils in Rats: Comprehensive Phytochemical, Pharmacological, and Histological Studies Tackling AGE/RAGE and Nrf2/Ho-1 Cue

Ayat M. Emad, Engy A. Mahrous, Dalia M. Rasheed, Fatma Alzahraa M. Gomaa et autres

The Cucurbitaceae family includes several edible species that are consumed globally as fruits and vegetables. These species produce high volumes of seeds that are often discarded as waste. In this study, we investigate the chemical composition and biological activity of three seed …

Égypte, sa (code pays fourni par la source)

Enhanced Wound Healing Potential of Spirulina platensis Nanophytosomes: Metabolomic Profiling, Molecular Networking, and Modulation of HMGB-1 in an Excisional Wound Rat Model

Hanan Refai, Amira A. El-Gazar, Ghada M. Ragab, Doaa H. Hassan et autres

Excisional wounds are considered one of the most common physical injuries. This study aims to test the effect of a nanophytosomal formulation loaded with a dried hydroalcoholic extract of S. platensis on promoting excisional wound healing. The Spirulina platensis nanophytosomal formulation (SPNP) …

Égypte, fr, sa, jo (code pays fourni par la source)

Alleviation of hyperlipidemia, insulin resistance, and myopathy by nano selenium/ nano CoQ10 platform with simvastatin in hyperlipidemic rats; comprehensive outlook

Hagar B. Abo-Zalam, Ezz El Deen El Denshary, Rania A. Abdalsalam, Islam A. Khalil et autres

Abstract In the present work seeks to address the role of nanoencapsulated platform of Coenzyme Q10 (coQNPs) or selenium (SeNPs) in hyperlipidemia and alleviation of simvastatin-induced myopathy and adverse reactions. Physicochemical characters and zeta potential studies for solid nanoparticles (SLNPs), coQNPs and …

nl, Égypte (code pays fourni par la source)

In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-β1/SMAD3/NOX4 Cue

Hagar B. Abo-Zalam, Rania M. Abdelsalam, Rehab F. Abdel‐Rahman, Mohamed F. Abd‐Ellah et autres

Osteoarthritis (OA) is a complex disease characterized by structural, functional, and metabolic deteriorations of the whole joint and periarticular tissues. In the current study, we aimed to investigate the possible effects of tempol on knee OA induced by the chemical chondrotoxic monosodium …

Égypte (code pays fourni par la source)

The Antioxidant tempol delays the MIA-induced osteoarthritis progression in rats via modulation of signaling pathways involving TGF-β1/SMAD3/NOX4 axis

Hagar B. Abo-Zalam, Rehab F. Abdel‐Rahman, Mohamed F. Abd‐Ellah, Rania M. Abdalsalam et autres

Abstract Osteoarthritis (OA) is a complex disease characterized by structural, functional, and metabolic deteriorations of the whole joint and periarticular tissues. In the current study, we aimed to investigate the possible effects of tempol on knee OA induced by the chemical chondrotoxic …

Égypte, id (code pays fourni par la source)

Therapeutic advancement of simvastatin-loaded solid lipid nanoparticles (SV-SLNs) in treatment of hyperlipidemia and attenuating hepatotoxicity, myopathy and apoptosis: Comprehensive study

Hagar B. Abo-Zalam, Ezzeldein S. El-Denshary, Rania M. Abdelsalam, Islam A. Khalil et autres

This study set out to optimize simvastatin (SV) in lipid nanoparticles (SLNs) to improve bioavailability, efficacy and alleviate adverse effects. Simvastatin-loaded solid lipid nanoparticles (SV-SLNs) were prepared by hot-melt ultrasonication method and optimized by box-Behnken experimental design. Sixty Wister albino rats were …

Égypte (code pays fourni par la source)