Yutaka Yano

Corisin induces proteostasis stress to drive epithelial injury and pulmonary fibrosis

Hajime Fujimoto, Taro Yasuma, Corina N. D’Alessandro‐Gabazza, Masaaki Toda et autres

Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease lacking clarity on the mechanisms linking epithelial injury to fibrotic remodeling. Here, we identify the microbiota-derived corisin as a potent, multifaceted driver of epithelial injury and pulmonary fibrosis. Leveraging targeted DNA sequencing of …

jp, us, fr (code pays fourni par la source)

Endocrinologist‐Led Management of Endocrine Immune‐Related Adverse Events: Real‐World Evidence Supporting the Japan Endocrine Society Guidelines

Kota Nishihama, Hajime Fujimoto, K. Saito, Chisa Inoue et autres

This retrospective observational study assessed the real-world management of endocrine immune-related adverse events (irAEs) in 84 patients treated with immune checkpoint inhibitors (ICIs) at a single center in Japan. Care was provided by endocrinologists and evaluated for consistency with the Japan Endocrine …

jp (code pays fourni par la source)

Effect of a Multifactorial Intervention on Retinopathy in People With Type 2 Diabetes

Takayoshi Sasako, Kohjiro Ueki, Kengo Miyoshi, Kana Miyake et autres

Importance: Prevention of diabetic retinopathy is important to keep vision and quality of life. Objective: To examine the effects of an intensive multifactorial intervention and hypoglycemia on retinopathy in people with type 2 diabetes. Design, Setting, and Participants: J-DOIT3 (Japan Diabetes Optimal …

jp, Kenya (code pays fourni par la source)

The use of fatty acid markers to distinguish hatchery and wild chum salmon fry and a description of post-stocking changes in fatty acid levels

Yutaka Yano, Koh Hasegawa, Kentaro Honda, Y Ogura

Fatty acid compositions of chum salmon ( Oncorhynchus keta ) fry were examined to distinguish between hatchery and wild fish in natural environments. Levels (%) of 18:2n-6 (linoleic acid) were significantly higher in fry obtained from a hatchery (13.0 %) than in …

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Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging

Taro Yasuma, Hajime Fujimoto, Corina N. D’Alessandro‐Gabazza, Masaaki Toda et autres

The increasing global prevalence of diabetic nephropathy poses substantial health and economic burdens. Currently, effective anti-fibrotic therapies for managing kidney fibrosis associated with chronic kidney disease are lacking. This study reveals corisin, a microbiota-derived peptide, as a central driver in the progression …

jp, us, fr (code pays fourni par la source)

An investigation on developing an effective method for improving pigmentation in the muscle of sockeye salmon Oncorhynchus nerka

Takeshi Yamamoto, Daisuke Izumida, Yutaka Yano, Hiroyuki Matsunari et autres

ベニザケ養殖では，配合飼料にアスタキサンチン（Ax）を添加しても天然ベニザケ特有の深紅の身色にならないことが課題となっている。本研究ではオキアミの給餌や飼料への油脂添加による効果を検討した。オキアミを単独で，またはAxを添加した飼料と併用給餌することにより，サーモン・カラー・チャートや分光測色計による身色が改善した。また，飼料への油脂添加によりAxのみかけの吸収率が高まり，身色が向上した。しかし，いずれの効果も十分ではなかったため，Axの吸収・蓄積をより改善する技術開発が必要と考えられた。

jp (code pays fourni par la source)

Massive stocking of chum salmon (Oncorhynchus keta) fry fattens non-native brown trout (Salmo trutta) in Hokkaido, Japan

Kentaro Honda, Koh Hasegawa, Masatoshi Ban, Yutaka Yano et autres

In Japan, stocked chum salmon (Oncorhynchus keta) fry may have become the perfect prey for non-native brown trout (Salmo trutta), which are popular targets of anglers. If this is the case, fry stocking which is intended to boost commercial fishing may be …

jp (code pays fourni par la source)

A case of rapidly progressive insulin-dependent diabetes mellitus without islet autoantibodies developed over two years after the first dose of nivolumab

Kota Nishihama, Yuko Okano, Chisa Inoue, Kanako Maki et autres

jp (code pays fourni par la source)

Reduced blood glucose levels by the combination of vadadustat in an elderly patient with chronic kidney disease who was receiving mitiglinide and sitagliptin: a case report

Ayumi Takakura, Toshinori Hirai, Naomi Hamaguchi, Rika Mukohara et autres

Abstract Background Our case is the first report showing the development of hypoglycemia following the administration of vadadustat in a patient with chronic kidney disease being treated with mitiglinide and sitagliptin, possibly due to drug–drug interaction between vadadustat and sitagliptin under the …

jp (code pays fourni par la source)

Bilateral Nephrectomy for Resistant Hypertension and Secondary Aldosteronism in a Hemodialysis Patient: A Case Report

Kota Nishihama, Chisa Inoue, Kohei Nishikawa, Yuko Okano et autres

A 42-year-old Japanese woman with end-stage renal failure due to hypertension presented with a systolic blood pressure of 160-200 mmHg despite treatment with 4 different antihypertensive agents. The plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were elevated. Adrenal vein sampling …

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DHA and EPA levels in a piscivorous fish changed by preying upon stocked salmon fry

Koh Hasegawa, Yutaka Yano, Kentaro Honda, Y Ogura

Increases in prey population size can affect the physiology and ecology of upper-trophic level organisms. This phenomenon is known as a bottom-up effect. For example, the increased abundance of prey resources can trigger physiological (internal) changes in predators, such as improvements in …

jp (code pays fourni par la source)

PS-BPC01-2: PREDICTORS AND EFFECTS OF COMORBID ATRIAL FIBRILLATION IN HYPERTENSIVE PATIENTS DUE TO PRIMARY ALDOSTERONISM

Shintaro Sakaguchi, Ryuji Okamoto, Chisa Inoue, Masaharu Akao et autres

Objective: The incidence of atrial fibrillation (AF) and risk of cardiovascular events are reportedly higher in patients with primary aldosteronism (PA) than those with essential hypertension. This study sought to determine independent predictors of comorbid AF and cardiovascular events in PA patients …

jp (code pays fourni par la source)