Xujiao Chen

Alteration in vitamin D catabolic enzyme 24-hydroxylase in aging renal tubules affect tubular transport function

Zhiqin Zhang, Xujiao Chen, Xin Tang, Jianping Mao et autres

Deficiency in vitamin D has been associated with aging-related diseases and an increased mortality risk. The kidneys are the main vitamin D producing organs. This study aimed to elucidate the alterations occurring in the renal vitamin D system during aging and their …

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Interpretable deep learning model for pediatric strangulated small bowel obstruction on CT: A multicenter study

Na Chang, Xin Liu, Peng Liu, Hengfei Gao et autres

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Malnutrition awareness and its determinants among Chinese older adults: findings from a cross-sectional survey

Fangzhou Li, Jingmei Zhang, Difei Wu, Xiyan Yu et autres

Background Malnutrition is a prevalent but underrecognized health issue among older adults in China. Inadequate awareness may delay detection and intervention, especially in cognitively vulnerable populations. To assess the level of malnutrition awareness and its association with sociodemographic, cognitive, and nutritional factors …

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Prevalence and Prognostic Significance of Malnutrition in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)

Jing Xu, Jing Li, Hanhan Chen, Qing Li et autres

Background: Non-alcoholic fatty liver disease (NAFLD) has become the primary cause of chronic liver disease. Although malnutrition is a common late-stage clinical consequence during the course of organ dysfunction and death in critical patients, it has not received sufficient attention in the …

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A greedy assist-as-needed controller for end-effect upper limb rehabilitation robot based on 3-DOF potential field constraints

Yue Lu, Zixuan Lin, Yahui Li, Jing Hui Lv et autres

It has been proven that robot-assisted rehabilitation training can effectively promote the recovery of upper-limb motor function in post-stroke patients. Increasing patients' active participation by providing assist-as-needed (AAN) control strategies is key to the effectiveness of robot-assisted rehabilitation training. In this paper, …

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Correlation Between Intrinsic Capacity and Muscle Strength and Quality in Older Patients with Cardiovascular Disease: A Cross-Sectional Study

Xiyan Yu, Difei Wu, Fangzhou Li, Wei Qiao et autres

Background: Cardiovascular disease (CVD) has become the leading cause of death worldwide. High muscle mass can reduce the incidence and mortality of CVD. In recent years, increasing attention has been given to the relationship between intrinsic capacity (IC) and CVD. This study …

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Vitamin D Receptor Deficiency Promotes Premature Aging by Inducing Pericytes and Microvessel Loss

Xujiao Chen

Background: Aging is a complex process influenced by a variety of factors and demonstrates organ-specific characteristics. A common hallmark of pathological changes across various organs is the decline in microvascular density. However, the molecular mechanisms governing organ-specific microvascular decline and aging are …

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Geriatric syndrome awareness and its determinants in China: a cross-sectional study

Difei Wu, Xiyan Yu, Fangzhou Li, Wei Qiao et autres

BACKGROUND: This study aims to investigate the awareness rate of six common geriatric syndromes and related influencing factors among the older adults aged 65 and above in China. METHODS: This is a multicenter cross-sectional study involving 6,653 participants aged 65 and older …

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PGC1α enhances macrophage efferocytosis in ox-LDL-stimulated RAW264.7 cells by regulating the NLRP3/PPARα axis

Qi Long Lu, Xujiao Chen, Qijun Zhang

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Application, knowledge and training needs regarding comprehensive geriatric assessment among geriatric practitioners in healthcare institutions: a cross-sectional study

Shanshan Shen, Xingkun Zeng, Xiaoliang Hui, Lingyan Chen et autres

BACKGROUND: This study aimed to investigate the actual application, knowledge, and training needs of comprehensive geriatric assessment (CGA) among geriatric practitioners in China. METHODS: A total of 225 geriatric practitioners attending the geriatric medicine or geriatric nursing training were recruited for this …

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A Hybrid Intelligent Classification System for Geriatric Frailty Syndrome Prevention and Control

Cong-chi Cai, Hui Liu, Xujiao Chen, Yanfei Li

As a typical condition of geriatric syndromes, it is speculated that frailty syndrome arises from dysfunctional feedback mechanisms among interacting physiological systems. To assess the frailty of the elderly for effective prevention and control in comprehensive geriatric syndromes medical base, this paper …

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A Lightweight Parkinson's Disease Diagnostic Method Based on Hand-Drawn Spiral Lines

Lulu Wang, Hui Liu, Xujiao Chen, Yanfei Li

This study proposes a lightweight model based on support vector machines (SVM) for the diagnosis of Parkinson's disease, which is convenient for migration embedding. It is primarily applied in community and elderly care settings. The method achieves accurate Parkinson's disease diagnosis through …

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