Emmanuel Donnadieu

Precision-cut tumor tissue slices, a novel tool to study the tumor microenvironment interactions with chimeric antigen receptor (CAR) T cells

Valeria Durante, Benjamin Theek, Manuel Martinez-Osuna, Emmanuel Donnadieu et autres

Up until present day, chimeric antigen receptor (CAR)-T cell therapy has only been approved for hematological malignancies, as CAR-T cells do not show comparable efficacy in solid tumors. Therefore, understanding the features of the tumor microenvironment (TME), is key to improve efficacy …

de, fr (code pays fourni par la source)

Precision-Cut Tumor Tissue Slices as a Tool to Study the Tumor Microenvironment Interactions with Chimeric Antigen Receptor (CAR) T Cells v1

Valeria Durante, Benjamin Theek, Manuel Martinez-Osuna, Emmanuel Donnadieu et autres

Up to date chimeric antigen receptor (CAR)-T cell therapy has been approved only for hematological malignancies, as CAR-T cells do not show comparable efficacy in solid tumors. Therefore, understanding the features of the tumor microenvironment (TME) is key to achieve improved efficacy …

Checkpoint inhibition enhances cell contacts between CD4+ T cells and Hodgkin-Reed-Sternberg cells of classic Hodgkin lymphoma

Kübra Yadigaroglu, Sonja Scharf, Steffen Gretser, Hendrik Schäfer et autres

Although checkpoint molecules like CTLA-4 and PD1 have been described several years ago, checkpoint inhibitors such as nivolumab (an anti-PD-1 antibody) have only recently been used to treat classic Hodgkin lymphoma (cHL). Several studies have shown convincing therapeutic effects of nivolumab in …

de, fr (code pays fourni par la source)

Targeted Alpha Particle Therapy Remodels the Tumor Microenvironment and Improves Efficacy of Immunotherapy

Justine Perrin, Marisa Capitao, Mathilde Allard, Nicolas Chouin et autres

fr, de (code pays fourni par la source)

Ex Vivo Imaging of Resident CD8 T Lymphocytes in Human Lung Tumor Slices Using Confocal Microscopy

Elisa Peranzoni, Houcine Bougherara, Sarah Barrin, Audrey Mansuet‐Lupo et autres

CD8 T cell are key players in the fight against cancer. In order for CD8 T cells to kill tumor cells they need to enter into the tumor, migrate within the tumor microenvironment and respond adequately to tumor antigens. The recent development …

fr, gb (code pays fourni par la source)

Ex vivo Imaging of T Cells in Murine Lymph Node Slices with Widefield and Confocal Microscopes

Hélène Salmon, Ana Rivas-Caicedo, François Asperti-Boursin, Camille Lebugle et autres

Naïve T cells continuously traffic to secondary lymphoid organs, including peripheral lymph nodes, to detect rare expressed antigens. The migration of T cells into lymph nodes is a complex process which involves both cellular and chemical factors including chemokines. Recently, the use …

fr (code pays fourni par la source)