Steffen Gretser

Die Diagnostik des klassischen Hodgkin-Lymphoms und seiner Imitatoren

Steffen Gretser, Ilske Oschlies, Karoline Koch, Wolfram Klapper

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Diagnostic assessment of Hirschsprung disease using fluorescence confocal microscopy: A feasibility study

Yannick Braun, Elise Gradhand, Florian Friedmacher, Barbara Walczak et autres

INTRODUCTION: Hirschsprung disease (HD) is a congenital disorder marked by aganglionosis of intestinal nerve plexuses, leading to bowel obstruction. Determining the extent of the aganglionic segment is essential for successful surgical correction. Consequently, the extent of aganglionosis must be examined histologically. Fluorescence …

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Claudin-18.2 im Cholangiokarzinom: erste immunhistochemische Expressionsanalysen

Maximilian N. Kinzler, Steffen Gretser, Falko Schulze, Katrin Bankov et autres

Einleitung: Die Anti-Claudin-18.2-Therapie (CLDN18.2) wurde kürzlich für die Behandlung von Adenokarzinomen des Magens oder des gastroösophagealen Übergangs zugelassen. Ziele: Ziel der vorliegenden Studie war es, erstmalig die Expression von CLDN18.2 im Cholangiokarzinom (CCA) zu untersuchen, um festzustellen, ob es Subgruppen von Patienten …

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Overexpression of KMT9α is associated with poor outcome in cholangiocarcinoma patients

Maximilian N. Kinzler, Eric Metzger, Katrin Bankov, Anna Ramos-Triguero et autres

PURPOSE: The newly discovered histone methyltransferase KMT9 serves as an epigenetic regulator of carcinogenesis in various cancer entities. For the first time, we investigated the presence of KMT9α in cholangiocarcinoma, the association with histologic subtypes, and its impact on survival. METHODS: A …

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Investigating the Potential of BH3 Mimetics and NK Cell Immunotherapy in Pediatric Sarcoma Treatment

R. Scott Pereira, A Wallenwein, Leonhard Michael Reindl, Sophia Thul et autres

Rhabdomyosarcoma (RMS) is the primary soft tissue cancer in children, with poor survival rates despite improvements. To uncover improved treatment alternatives, in vitro models that accurately reflect the tumors are necessary. Therefore, we established a pipeline to develop primary patient-derived cells as …

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Maschinelles Lernen zur Identifikation pathologischer Myokardregionen: ein innovativer Ansatz für die digitale Pathologie

Eva Corvest, Robin S. Mayer, C. Kocuk, Verena Wilmes et autres

Zusammenfassung Hintergrund/Fragestellung Digitalisierung und künstliche Intelligenz (KI) werden zunehmend in der Auswertung histologischer Schnitte getestet und eingesetzt. Während die Anwendung im Bereich der Tumorpathologie bereits weit fortgeschritten ist, sind Erfahrungen mit der digitalen Auswertung histologischer Schnitte des Myokards limitiert. Wir stellen ein …

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Expression of claudin‐18.2 in cholangiocarcinoma: a comprehensive immunohistochemical analysis from a German tertiary centre

Maximilian N. Kinzler, Steffen Gretser, Falko Schulze, Katrin Bankov et autres

Aims Anti‐claudin‐18.2 (CLDN18.2) therapy was recently approved for the treatment of gastric or gastro‐oesophageal junction adenocarcinoma. The aim of the present study was to investigate the expression of CLDN18.2 in cholangiocarcinoma (CCA) to determine whether there is a subgroup of patients who …

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Fresh Hemorrhages in Intestinal Resection Margins Are Associated with Unfavorable Clinical Outcomes in Preterm Infants with Necrotizing Enterocolitis with Surgical Intervention

Ole Schickedanz, Florian Friedmacher, Steffen Gretser, Yannick Braun et autres

BACKGROUND: Necrotizing enterocolitis (NEC) is a common disease in premature infants. If conservative treatment does not respond, surgical removal of the necrotic section of bowel is common practice. This study investigates whether there is a correlation between the histopathological findings and the …

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Fluorescence confocal microscopy for evaluation of fresh surgical specimens and consecutive tumor cell isolation in rare pediatric tumors

Steffen Gretser, Maximilian N. Kinzler, Till‐Martin Theilen, Peter Johannes Wild et autres

Fluorescence confocal microscopy (FCM) is an optical technique that uses laser light sources of different wavelengths to generate real-time images of fresh, unfixed tissue specimens. FCM allows histological evaluation of fresh tissue samples without the associated cryo artifacts after frozen sectioning. The …

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Fluorescence Confocal Microscopy Can Accelerate Diagnosis of Cervical Lymphadenopathy

Steffen Gretser, Aresu Sadeghi Shoreh Deli, Andreas German Loth, Peter Johannes Wild et autres

Fluorescence confocal microscopy (FCM) is an optical technique that uses laser light sources of different wavelengths to generate real-time images of fresh, unfixed tissue specimens. Unlike conventional histologic evaluation methods, FCM is able to assess fresh tissue samples without the associated cryo …

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Checkpoint inhibition enhances cell contacts between CD4+ T cells and Hodgkin-Reed-Sternberg cells of classic Hodgkin lymphoma

Kübra Yadigaroglu, Sonja Scharf, Steffen Gretser, Hendrik Schäfer et autres

Although checkpoint molecules like CTLA-4 and PD1 have been described several years ago, checkpoint inhibitors such as nivolumab (an anti-PD-1 antibody) have only recently been used to treat classic Hodgkin lymphoma (cHL). Several studies have shown convincing therapeutic effects of nivolumab in …

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Combination of BH3 mimetics with NK cell-based immunotherapy as a potential novel treatment option for pediatric sarcoma

R. Scott Pereira, A Wallenwein, Moni Birkhold, Leonhard Michael Reindl et autres

Rhabdomyosarcoma (RMS) is the most prevalent malignant soft tissue cancer in children. Despite intensive therapy regimens, survival rates are low, and better treatment options are urgently required. To discover improved treatment alternatives, in vitro models accurately reflecting tumor biology are necessary. Therefore, …