Roshell Muir

Macrophage-derived extracellular vesicles promote T cell–dependent inflammatory pain resolution

Jason Wickman, Richa Pande, Jason DaCunza, Deepa Reddy et autres

Abstract Inflammatory pain resolution is increasingly recognized as an active, immune-regulated process, yet the adaptive immune mechanisms that govern this process remain poorly defined. We previously demonstrated that intrathecal administration of macrophage-derived small extracellular vesicles (sEVs) from unstimulated (sEV) or LPS-stimulated (sEV …

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A Holistic, Data-Driven Approach to Diversifying Alpha Omega Alpha (AΩA) Honor Society Electees

Seema Baranwal, Carolyn Giordano, Leon McCrea, Jennifer Hamilton et autres

Recently, some medical schools eliminated their Alpha Omega Alpha (AΩA) chapters because of concerns that AΩA academic criteria led to bias in student selection. In 2020, the AΩA board changed the constitution to permit individual member schools to determine how their electees …

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Pathway to Medicine and Health Programs Revisited: Outcomes and Institutional Adaptations in Greater Philadelphia and Beyond

Dara Bright, Sarah Hughes, Roshell Muir

This scoping literature review examines the outcomes and institutional adaptations of pathway programs designed to increase diversity in medical and allied health professions. These programs address systemic barriers faced by students from underrepresented (UR) backgrounds through a targeted focus on improving their …

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The evolution of character education in medicine

Julie K. Silver, Amber K Brooks, Suzanne C. Danhauer, Chris Gillette et autres

The evolution of character education represents an important development in medical education and leadership training. As character education becomes a more important part of training, it must tran...

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Characterization of a Novel Transmembrane Activating STING Agonist using Genetically Humanized Mice

Nobuyo Mizuno, Jinu Abraham, Kevin Jimenez-Perez, Laura Springgay et autres

Abstract STING is a pattern recognition receptor that activates type I interferon and proinflammatory responses in addition to unrelated molecular processes following exposure of DNA to the cytosol. Its pharmacologic stimulation enhances vaccine potency and generates effective antitumor responses but clinical trials …

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Faculty belonging may be more important than we realize

Jaspal Singh, Roshell Muir, Yasmain Rice‐Greene, Joshua C. Patt et autres

Faculty belonging may be more important than we realize. Un article de la revue Canadian Medical Education Journal / Revue canadienne de l'éducation médicale (Volume 16, numéro 3, 2025, p. 1-331) diffusée par la plateforme Érudit.

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A STUDY OF HYPERON PRODUCTION BY 430 Mev/c K$sup -$-MESONS IN HELIUM

Roshell Muir

Activation of CXCR3 + Tfh cells and B cells in lymph nodes during acute HIV-1 infection correlates with HIV-specific antibody development

Julie L. Mitchell, Supranee Buranapraditkun, Pierre Gantner, Hiroshi Takata et autres

ABSTRACT Lymph node T follicular helper (Tfh) cells and germinal center (GC) B cells are critical to generate potent antibodies but are rarely possible to study in humans. To understand how Tfh/GC B-cell interactions during acute HIV-1 infection (AHI) impact the generation …

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Letter to the Editor on ‘Faculty Development for the People: Workplace‐Based Solutions for Busy Clinicians’

Cara Haberman, Jaspal Kaur Singh, Julie K. Silver, Joshua C. Patt et autres

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

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Re: Why Do Physicians Depart Their Practice? A Qualitative Study of Attrition in a Multispecialty Ambulatory Practice Network

Roshell Muir, Lauren D. Feld, Monica Verduzco‐Gutierrez

To the Editor: We read with great interest the article from O’Connell and colleagues on drivers of departure for physicians from a multispecialty ambulatory practice.[1][1] Physician turnover can be attributed to both push and pull factors.[2][2] Push factors are typically negative that …

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The molecular immune modulator adenosine deaminase-1 enhances HIV specific humoral and cellular responses to a native-like HIV envelope trimer DNA vaccine

Michele A. Kutzler, Gina Cusimano, David Joyner, Emily Konopka et autres

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Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity

Jennifer Connors, Gina Cusimano, Nathan Mege, Kyra Woloszczuk et autres

In the field of immunology, a systems biology approach is crucial to understanding the immune response to infection and vaccination considering the complex interplay between genetic, epigenetic, and environmental factors. Significant progress has been made in understanding the innate immune response, including …

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