Accès ouvert
2026
article
OpenAlex
Nobuyo Mizuno, Jinu Abraham, Kevin Jimenez-Perez, Ian Rose et autres
Stimulator of interferon genes (STING) is a pattern recognition receptor that activates type I interferon and proinflammatory responses following cytosolic DNA exposure. Its pharmacologic stimulation enhances vaccine potency and generates anti-tumor responses, but clinical trials evaluating STING agonists have not supported human …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Nobuyo Mizuno, Jinu Abraham, Kevin Jimenez-Perez, Laura Springgay et autres
Abstract STING is a pattern recognition receptor that activates type I interferon and proinflammatory responses in addition to unrelated molecular processes following exposure of DNA to the cytosol. Its pharmacologic stimulation enhances vaccine potency and generates effective antitumor responses but clinical trials …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Nobuyo Mizuno, Dylan T. Boehm, Kevin Jimenez-Perez, Jinu Abraham et autres
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Nobuyo Mizuno, Dylan T. Boehm, Kevin Jimenez-Perez, Jinu Abraham et autres
ABSTRACT Pharmacologic activation of the innate immune response is being actively being pursued for numerous clinical purposes including enhancement of vaccine potency and potentiation of anti-cancer immunotherapy. Pattern recognition receptors (PRRs) represent especially useful targets for these efforts as their engagement by …
us
(code pays fourni par la source)
Accès ouvert
2023
supplementary-materials
OpenAlex
Jinu Abraham, Suresh I. Prajapati, Koichi Nishijo, Beverly S. Schaffer et autres
Supplementary Figures 1-4 from Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma
Accès ouvert
2023
supplementary-materials
OpenAlex
Jinu Abraham, Suresh I. Prajapati, Koichi Nishijo, Beverly S. Schaffer et autres
Supplementary Methods, Figure Legends 1-4 from Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma
Accès ouvert
2023
supplementary-materials
OpenAlex
Jinu Abraham, Suresh I. Prajapati, Koichi Nishijo, Beverly S. Schaffer et autres
Supplementary Methods, Figure Legends 1-4 from Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma
Accès ouvert
2023
supplementary-materials
OpenAlex
Jinu Abraham, Suresh I. Prajapati, Koichi Nishijo, Beverly S. Schaffer et autres
Supplementary Figures 1-4 from Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma
Accès ouvert
2023
other
OpenAlex
Jinu Abraham, Suresh I. Prajapati, Koichi Nishijo, Beverly S. Schaffer et autres
Abstract Inhibition of the insulin-like growth factor 1 receptor (Igf1r) is an approach being taken in clinical trials to overcome the dismal outcome for metastatic alveolar rhabdomyosarcoma (ARMS), an aggressive muscle cancer of children and young adults. In our study, we address …
Accès ouvert
2023
other
OpenAlex
Jinu Abraham, Suresh I. Prajapati, Koichi Nishijo, Beverly S. Schaffer et autres
Abstract Inhibition of the insulin-like growth factor 1 receptor (Igf1r) is an approach being taken in clinical trials to overcome the dismal outcome for metastatic alveolar rhabdomyosarcoma (ARMS), an aggressive muscle cancer of children and young adults. In our study, we address …
Accès ouvert
2023
supplementary-materials
OpenAlex
Tohru Hosoyama, Mohammed Aslam, Jinu Abraham, Suresh I. Prajapati et autres
Supplementary Figures S1-S3; Supplementary Table S1.
Accès ouvert
2023
other
OpenAlex
Tohru Hosoyama, Mohammed Aslam, Jinu Abraham, Suresh I. Prajapati et autres
Abstract Purpose: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. The alveolar subtype of rhabdomyosarcoma (ARMS) is a paradigm for refractory and incurable solid tumors because more than half of the children at diagnosis have either regional lymph node …