Sara Elitzur

Near-tetraploid T-cell acute lymphoblastic leukaemia in childhood: Results of the AIEOP-BFM ALL studies

Francesco Ceppi, Giacomo Gotti, Anja Möricke, Daniela Silvestri et autres

BACKGROUND: Near-tetraploidy-defined by DNA index 1.79-2.28 or 81-103 chromosomes-is a rare cytogenetic abnormality observed both in children and adults with T-cell acute lymphoblastic leukaemia (T-ALL) and its prognostic value is not yet determined. PATIENTS AND METHODS: We report a retrospective study conducted …

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Outcomes of paediatric patients with B-cell acute lymphocytic leukaemia with ABL-class fusion in the pre-tyrosine-kinase inhibitor era: a multicentre, retrospective, cohort study

Monique L. den Boer, Gunnar Cario, Anthony V. Moorman, Judith M. Boer et autres

Background ABL-class fusion genes other than BCR–ABL1 have been identified in approximately 3% of children with newly diagnosed acute lymphocytic leukaemia, and studies suggest that leukaemic cells carrying ABL-class fusions can be targeted successfully by tyrosine-kinase inhibitors. We aimed to establish the …

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Anti- Inflammatory Treatment in Pediatric Advanced Myelodysplastic Syndrome Associated with Inflammatory Manifestations May Reverse Progression and Bridge to a Successful HSCT

Asaf Yanir, Shlomit Barzilai‐Birenboim, Hanna Tamary, Orna Steinberg‐Shemer et autres

Introduction Inflammatory Manifestations (IM) are well described in 10-30% of adult patients with Myelodysplastic Syndrome (MDS). Most case series do not report correlation between cytogenetic or MDS type. Different treatment modalities have been tried, but their role in relation to HSCT has …

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Growth and pubertal patterns in young survivors of childhood acute lymphoblastic leukemia

Sara Elitzur, Revital Houri-Shtrecher, Michal Yackobovitz-Gavan, Galia Avrahami et autres

Several previous studies had focused on the early risk of metabolic syndrome or its components in survivors of childhood acute lymphoblastic leukaemia (ALL), while fewer data are available on pubertal development in these subjects. The merit of this study was to carefully …

Therapeutic Drug Monitoring of Asparaginase Activity—Method Comparison of MAAT and AHA Test Used in the International AIEOP-BFM ALL 2009 Trial

Claudia Lanvers‐Kaminsky, Andrea Rüffer, Gudrun Würthwein, Joachim Gerß et autres

BACKGROUND: In the international AIEOP-BFM ALL 2009 trial, asparaginase (ASE) activity was monitored after each dose of pegylated Escherichia coli ASE (PEG-ASE). Two methods were used: the aspartic acid β-hydroxamate (AHA) test and medac asparaginase activity test (MAAT). As the latter method …

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Response of Symptomatic Persistent Chronic Disseminated Candidiasis to Corticosteroid Therapy in Immunosuppressed Pediatric Patients: Case Study and Review of the Literature

Vered Shkalim‐Zemer, Itzhak Levi, Salvador Fischer, Hannah Tamary et autres

BACKGROUND: Chronic disseminated candidiasis (CDC) is a severe invasive fungal infection principally observed during neutrophil recovery in patients with acute leukemia treated with intensive chemotherapy. Its pathophysiology remains unclear. We describe the management of 6 children with symptomatic CDC who did not …

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Mir Expression Profile of Peripheral Blood Lymphocytes Predicts Relapse in Pediatric Acute Lymphoblastic Leukemia

Smadar Avigad, Keren Shichrur, Sara Elitzur, Gil Gilad et autres

Abstract Introduction: Our previous findings showed that the microRNA (miR) expression profile of miR-151, miR-1290 and miR-451 measured in bone marrow (BM) aspirations taken at diagnosis can predict risk of relapse in pediatric acute lymphoblastic leukemia (ALL) patients treated according to BFM …

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Characteristics and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia: Comparison Between Ethnic Populations in Israel

Ronit Elhasid, Aya Abramov, Nira Arad -Cohen, Dina Attias et autres

Abstract Background and aims: Differences in outcome and disease characteristics of childhood acute lymphoblastic leukemia (ALL) among ethnic groups were reported worldwide. We explored such differences among ethnic populations in Israel. Methods: Patient and disease characteristics and outcome were compared retrospectively among …

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Frequency and Prognostic Relevance of Gene Mutations in Pediatric AML Patients At First Relapse.

Costa Bachas, Gerrit Jan Schuurhuis, Dirk Reinhardt, Ursula Creutzig et autres

Abstract Abstract 2480 Relapsed pediatric AML patients respond poorly to conventional re-induction therapy and as a consequence long term survival rates of these patients are low (up to 36%). Accurate characterization and risk group stratification at first relapse may facilitate personalized, targeted …

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