Lawrence Chauke

Strengthening gestational diabetes mellitus prevention, diagnosis, and care in Africa: evidence and policy priorities from a systematic review, meta-analysis, and bibliometric analysis

Benjamin Aye Simon, Lawrence Chauke, Nalini Govender, Chester Kalinda et autres

Gestational diabetes mellitus (GDM) is an increasing public health challenge in Africa, contributing substantially to maternal and neonatal morbidity. Evidence from our systematic review, meta-analysis, and bibliometric analysis shows that inconsistent screening practices, reliance on selective rather than universal testing, and limited …

Afrique du Sud, Rwanda (code pays fourni par la source)

Bridging the Diagnostic Gap: Reviewing Current Endometriosis Screening Tools and Models

Fatima Kathrada, Armorel Van Eyk, Lawrence Chauke

Background: Endometriosis affects 10% of reproductive-aged women globally and is one of the major causes of infertility. It is a debilitating, chronic condition with an average diagnostic delay of up to 10 years. This is partly due to the lack of noninvasive …

Afrique du Sud (code pays fourni par la source)

Clinical Performance of sFlt-1/PlGF Ratio Triage in Suspected Preeclampsia: A Prospective, Observational Multicenter Diagnostic-Triage Study in South Africa (TsHEPPO Study)

I Bhorat, Priya Soma‐Pillay, Lawrence Chauke, Mushi Matjila et autres

Objective To evaluate the diagnostic and short-term predictive performance of the sFlt-1/PlGF ratio for triaging suspected preeclampsia (PE) in South Africa, comparing the established ≥38 threshold with an exploratory cut-off of ≥33 in a predominantly African ancestry population Design and Setting Prospective, …

Afrique du Sud (code pays fourni par la source)

Epidemiology, diagnostics, treatments, and pregnancy outcomes of gestational diabetes mellitus in Africa: a systematic review, meta-analysis, and bibliometric study

Benjamin Aye Simon, Yasmeen Thandar, Nalini Govender, Francis Akpa-Inyang et autres

Background: Gestational diabetes mellitus (GDM) is an increasingly important contributor to maternal and neonatal morbidity in Africa, yet the evidence base remains fragmented across settings and research domains. This study integrates systematic review and meta-analysis with bibliometric analysis to synthesize epidemiological evidence, …

Afrique du Sud (code pays fourni par la source)

Mental health patterns and associated social determinants among university and college students in sub-Saharan Africa during the COVID-19 pandemic era: a scoping review

Memory Muturiki, Nontsikelelo O. Mapukata, Lawrence Chauke, Sara Jewett

Background: Evidence on student mental health in sub-Saharan Africa (SSA) remains limited, particularly studies examining how mental health patterns intersect with social determinants within higher education institutions (HEIs). This scoping review identifies gaps in the literature documenting student mental health and associated …

Afrique du Sud (code pays fourni par la source)

Protein C Levels in Human Immunodeficiency Virus-Infected Women with and Without Pre-Eclampsia in South Africa

Wendy N. Phoswa, Lawrence Chauke, Kabelo Mokgalaboni, Gaynor M. Balie et autres

Background: Pre-eclampsia (PE) is a significant cause of maternal and perinatal morbidity and mortality globally and is characterized by impaired endothelial function and disturbances in coagulation pathways. The effects of Human Immunodeficiency Virus (HIV) on the immune and coagulation systems have been …

Afrique du Sud (code pays fourni par la source)

The use of novel biomarkers for gestational diabetes mellitus diagnosis: A targeted omics study in African women

Lungile Khambule, Jaya A. George, Lawrence Chauke, Nigel Crowther

Objectives: This study aimed to evaluate whether IL-6, TNF-α, free fatty acids (FFAs), branched-chain amino acids (BCAAs), and acylcarnitines (C2, C4, C5, and C8) were associated with glycaemia in early and late stages of pregnancy Design: Multicentre Cross-sectional study Population: African women …

Afrique du Sud (code pays fourni par la source)

Global variability in the clinical presentation of endometriosis: A scoping review

Fatima Kathrada, Armorel van Eyk, Lawrence Chauke

Endometriosis affects approximately 10-15 percent of women of reproductive age, yet its clinical presentation remains inconsistently reported. This scoping review mapped the global spectrum of endometriosis-related symptoms and examined factors influencing symptom reporting. Following the JBI framework, studies were identified using two …

Afrique du Sud (code pays fourni par la source)

Maternal deaths due to suicide: A 5-year retrospective analysis in a district in South Africa

J Basu, Aimee Stewart, Lawrence Chauke

Afrique du Sud (code pays fourni par la source)

Clinical Performance of sFlt‐1/PlGF Ratio Triage in Suspected Preeclampsia: A Prospective Interventional Multicenter Study in South Africa: the TSHEPPO Trial

Ismail Bhorat, Priya Soma‐Pillay, Lawrence Chauke, Mushi Matjila et autres

Objective To evaluate the diagnostic and short-term predictive performance of the sFlt-1/PlGF ratio for triaging suspected preeclampsia (PE) in South Africa, comparing the established ≥38 threshold with an exploratory cut-off of ≥33 adapted for African descent cohorts. Design and Setting: Prospective, interventional, …

Afrique du Sud, gb (code pays fourni par la source)

Providers’ Perceptions of Respectful Maternity Care and Enabling Conditions in a Regional Hospital: A Qualitative Study

Sthembile P. Zwane, Lawrence Chauke

Globally, women continue to die from pregnancy-related conditions that could be prevented through ensuring timely access to emergency obstetric care and facility-based deliveries supervised by skilled birth attendants. However, many women are reluctant to deliver in maternity healthcare facilities due to the …

Afrique du Sud (code pays fourni par la source)

Prevalence of Depressive Symptoms Amongst Pregnant Women Attending Antenatal Clinics at Quaternary Hospital in Johannesburg, South Africa: A Cross-Sectional Study

Ugasvaree Subramaney, Lawrence Chauke

Antenatal depression significantly contributes to maternal and neonatal morbidity worldwide; however, the rate of screening, particularly in low- and middle-income countries (LMICs), remains very low. This cross-sectional survey study was aimed at determining the prevalence of depressive symptoms among women aged 18 …

Afrique du Sud (code pays fourni par la source)