John Audley

Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury

Hannah D. Mason, Ganesha Rai, Arina V. Kozyr, Nathaniel De Jonge et autres

NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes. However, overproduction of ROS by these enzymes is associated with cardiovascular disease, fibrosis, traumatic …

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Granulibacter bethesdensis, a Pathogen from Patients with Chronic Granulomatous Disease, Produces a Penta-Acylated Hypostimulatory Glycero-D-talo-oct-2-ulosonic Acid–Lipid A Glycolipid (Ko-Lipid A)

Artur Muszyński, Kol A. Zarember, Christian Heiß, Joseph Shiloach et autres

Granulibacter bethesdensis can infect patients with chronic granulomatous disease, an immunodeficiency caused by reduced phagocyte NADPH oxidase function. Intact G. bethesdensis (Gb) is hypostimulatory compared to Escherichia coli, i.e., cytokine production in human blood requires 10–100 times more G. bethesdensis CFU/mL than …

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Low Plasma Gelsolin Concentrations in Chronic Granulomatous Disease

John Audley, Emily F. Gliniewicz, Kol A. Zarember, Hanna S. Hong et autres

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