Arina V. Kozyr

Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury

Hannah D. Mason, Ganesha Rai, Arina V. Kozyr, Nathaniel De Jonge et autres

NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes. However, overproduction of ROS by these enzymes is associated with cardiovascular disease, fibrosis, traumatic …

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Preparative Production and Purification of Recombinant Human Cyclophilin A

Anastasiia A. Kalinina, Alexander V. Kolesnikov, Arina V. Kozyr, Natalia L. Kulikova et autres

In this work, we developed the method of preparative production of recombinant human cyclophilin A (rhCypA) in Escherichia coli. The full-length cDNA encoding the gene of human CypA (CYPA) was amplified by RT-PCR from the total RNA of human T cell lymphoma …

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Granulibacter bethesdensis, a Pathogen from Patients with Chronic Granulomatous Disease, Produces a Penta-Acylated Hypostimulatory Glycero-D-talo-oct-2-ulosonic Acid–Lipid A Glycolipid (Ko-Lipid A)

Artur Muszyński, Kol A. Zarember, Christian Heiß, Joseph Shiloach et autres

Granulibacter bethesdensis can infect patients with chronic granulomatous disease, an immunodeficiency caused by reduced phagocyte NADPH oxidase function. Intact G. bethesdensis (Gb) is hypostimulatory compared to Escherichia coli, i.e., cytokine production in human blood requires 10–100 times more G. bethesdensis CFU/mL than …

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Shaperone-Dependent Optimization of Expression in E. coli and Purification of Soluble Recombinant Lipid A Phosphatase LpxE from Francisella tularensis

Arina V. Kozyr, L. A. Lisitskaya, A. K. Ryabko, Natalia A. Zeninskaya et autres

Lipid-1a-phosphatase LpxE cleaves the phosphate group in the first position of lipid A of lipopolysaccharide in Gram-negative bacteria, which reduces toxicity and reactogenicity of bacterial endotoxin while maintaining its immunogenicity. Treatment with these enzymes in preparations of recombinant proteins obtained in bacterial …

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Получение и иммуногенные свойства рекомбинантного пептидогликан-ассоциированного липопротеина (Pal) Legionella pneumophila

Зенинская Наталья Алексеевна, Alena K. Riabko, Artem Vladimirovich Kolesnikov, Arina V. Kozyr et autres

Shaperone-dependent optimization of expression in E.coli and purification of soluble recombinant lipid a phosphatase LpxE from Francisella tularensis

Arina V. Kozyr, L. A. Lisitskaya, A. K. Ryabko, Natalia A. Zeninskaya et autres

Evolution of inhibitor-resistant natural mutant forms of HIV-1 protease probed by pre-steady state kinetic analysis

Maria Yu. Zakharova, А. А. Кузнецова, Elena N. Kaliberda, Maria A. Dronina et autres

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Immune response to Vi-antigen of Salmonella typhi is dependent on introduction of positive charge and shape of charged group into polysaccharide

Alexander V. Kolesnikov, Arina V. Kozyr, A. K. Ryabko, I. G. Shemyakin et autres

A model of a controlled conversion of polysaccharide Vi-antigen of S. typhi into zwitterionic antigen is proposed. The immunological properties of modifications of this antigen conjugated to a protein support were studied.

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ИММУННЫЙ ОТВЕТ К VI-АНТИГЕНУ SALMONELLA TYPHI ЗАВИСИТ ОТ ВВОДИМОГО В ПОЛИСАХАРИД ПОЛОЖИТЕЛЬНОГО ЗАРЯДА И ТИПА ЗАМЕСТИТЕЛЯ, НЕСУЩЕГО ЭТОТ ЗАРЯД

Alexander V. Kolesnikov, Arina V. Kozyr, Alena K. Riabko, И Г Шемякин et autres

Aptamers in the Treatment of Bacterial Infections: Problems and Prospects

Natalia A. Zeninskaya, A. K. Ryabko, I. G. Shemyakin, Ivan Alekseevich Dyatlov et autres

Aptamers are short single-stranded oligonucleotides which are selected via targeted chemical evolution in vitro to bind a molecular target of interest. The aptamer selection technology is designated as SELEX (Systematic evolution of ligands by exponential enrichment). SELEX enables isolation of oligonucleotide aptamers …

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SYNTHETIC BIOLOGY AS AN INSTRUMENT FOR DEVELOPMENT OF INNOVATIVE VACCINES FOR PROPHYLAXIS OF BACTERIAL INFECTIONS

Alexander V. Kolesnikov, Arina V. Kozyr, L. G. Shemyakin, L. A. Lisitskaya et autres

For many decades, live vaccines remain the most effective means for prophylaxis of bacterial infections. Until recently, the main source of vaccine strains were empirically selected bacteria, virulence of which was attenuated due to natural mutations. Despite effectiveness of such vaccines against …

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PROTEINS AND OTHER CARRIERS FOR CREATION OF CONJUGATED VACCINES: PROPERTIES AND APPLICATION

L. A. Lisitskaya, Alexander V. Kolesnikov, Arina V. Kozyr, I. G. Shemyakin et autres

Vaccination is a key element in prophylaxis of infectious diseases. Effective vaccines based on polysaccharide capsules were developed for a number of microorganisms. Effectiveness of polysaccharides as antigens, however, is low in the main risk groups - infants and patients with immunedeficiency …

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