Yoshinori Hasegawa

Early administration of calcineurin inhibitors limits tolerogenic effect of PTCy in allogeneic hematopoietic transplant

Keisuke Kojima, Hajime Senjo, Shihori Tsukamoto, Ayumu Ito et autres

We recently demonstrated early administration of calcineurin inhibitors (CNIs) after murine allogeneic hematopoietic cell transplantation (allo-HCT) inhibits terminal exhaustion of donor T cells and hampers tolerance induction. However, the role of CNIs in regulating T-cell exhaustion in clinical allo-HCT remains to be …

jp (code pays fourni par la source)

Integrative Omics of Eosinophils in Asthma and COPD: Deciphering Molecular Signatures for Targeted Therapy

Jun Miyata, Keeya Sunata, Hisashi Sasaki, Shotaro Chubachi et autres

jp (code pays fourni par la source)

The expression modifier score (EMS) v2 enhances regulatory variant prioritization via Enformer-derived features and multi-task learning

Yugo Takahashi, Qingbo S. Wang, Takanori Hasegawa, Ho Namkoong et autres

Prioritizing causal variants in a regulatory region of the genome remains challenging. Here we introduce the Expression Modifier Score (EMS) v2, allowing prioritization of regulatory variants with high precision. EMSv2 achieves higher prediction performance compared to alternative methods, especially in tissues with …

jp, us (code pays fourni par la source)

IGF2BP3 is essential for the growth heterogeneity of colorectal adenoma cells by regulating MYC

Tomohiko Sunami, Roberto Coppo, Kunishige Onuma, Jumpei Kondo et autres

Adenoma is a major precancerous lesion in colorectal cancer (CRC), and the adenoma-carcinoma sequence is a well-known multistep progression to CRC caused by the accumulation of genetic mutations. On the other hand, the non-genetic mechanisms in the adenoma-carcinoma sequence remain largely unknown. …

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Durable antimicrobial coatings for hospital sink surfaces using hydrophobized TEMPO-oxidised cellulose nanofibre Pickering emulsions

Yoshitaka Ito, Toshiaki Takeuchi, Narumi Komami, Yoshinori Hasegawa et autres

Effective microbial control in water-associated environments, such as hospital sinks, is critical for preventing the spread of antimicrobial resistance in healthcare settings. Antimicrobial coatings represent a promising means for microbial control; however, their application on water-associated surfaces is challenging. Therefore, durable antimicrobial …

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IL ‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato et autres

BACKGROUND: IL-33 levels are elevated in the airways of patients with eosinophilic diseases, and IL-33 receptor expression on eosinophils is upregulated in type 2-high environments. However, the role of IL-33 in the regulation of human eosinophils remains unclear. OBJECTIVE: To elucidate the …

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Differential Transcriptomic Features of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis with and Without Extrapulmonary Lesions in an East Asian Population

Yushi Murai, Takeshi Kawasaki, Takuro Imamoto, Daisuke Ishii et autres

Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Pulmonary sarcoidosis with extrapulmonary lesions (EPL) confers poor prognoses. The transcriptomic features of peripheral blood mononuclear cells (PBMCs) could be crucial in sarcoidosis pathogenesis. However, the gene expression characteristics associated with EPL …

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Multiomics insights into retinoic acid–mediated regulation of eosinophils in severe asthma

Jun Miyata, Keeya Sunata, Hisashi Sasaki, Yusuke Kawashima et autres

BACKGROUND: Severe asthma is marked by persistent eosinophilic inflammation, but the role of all-trans retinoic acid (ATRA) in eosinophil homeostasis remains unclear. OBJECTIVE: This study examined the regulatory role of ATRA in eosinophil function in severe asthma. METHODS: Multiomics analysis (transcriptomics, proteomics, …

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RNA-Sequencing Analysis of Escherichia coli Suspended in Conductive Water Column Falling into Dielectric Barrier Discharge Gap

Kazunori Kadowaki, Hiroshi Kataoka, Ryo Matsuda, Shinji Yudate et autres

This study uniquely applies RNA-sequencing analysis to elucidate the molecular mechanism underlying Escherichia coli (DH10B) inactivation by dielectric barrier discharge (DBD). This provides new insights into the changes in gene expression associated with oxidative stress and membrane damage. A thin water column …

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Foxp3 and BATF cooperatively direct cis -regulatory programs and gene expression for functional differentiation of Treg cells

Ryuichi Murakami, Norihito Hayatsu, Takahisa Miyao, Shumpei Shibata et autres

SUMMARY Mechanisms by which diverse transcription factors (TFs) shape the heterogeneous transcriptional and epigenetic landscape of regulatory T (Treg) cells remain poorly understood. By investigating interactions between BATF and Foxp3 TFs, we discovered their cooperative roles in directing cis -regulatory programs and …

jp, fr, ch (code pays fourni par la source)

Optimization of Immunosuppressive Therapy by Epitope Matching

Yoshinori Hasegawa

Purpose: We previously reported that de novo donor-specific antibody (dnDSA) production is strongly associated with HLA molecular matching, where fewer mismatches in both B cell and T cell epitopes result in lower dnDSA production. The next challenge is determining whether immunosuppressive therapy …

Peptidylarginine Deiminase 4 Deficiency Suppresses Neutrophil Extracellular Trap Formation and Ameliorates Elastase-Induced Emphysema in Mouse Lung

Megumi Katsumata, Jun Ikari, Akira Urano, Eiko Suzuki et autres

Neutrophil extracellular traps (NETs) are associated with the extracellular release of nuclear chromatin decorated with cytoplasmic proteins. Excessive release of NETs has been reported in chronic lung diseases, including chronic obstructive pulmonary disease (COPD). However, the role of NETs in the pathogenesis …

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