Ezequiel Ruíz-Mateos

Elevated Plasma GDF-15 Levels are Associated with the Immune Non-Responder Phenotype in People with HIV

Aida López López, Jacobo Alonso Domínguez, Inés Martínez Barros, Alexandre Pérez‐González et autres

INTRODUCTION: Most people with HIV (PWH) achieve immune recovery with antiretroviral therapy (ART); however, a clinically relevant subset, known as immune non-responders (INRs), fails to restore CD4+ T-cell counts despite sustained virological suppression and shows persistent immune dysfunction. Growth differentiation factor 15 …

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Editorial introductions

Ezequiel Ruíz-Mateos

Novel attributes of HIV-1 elite controllers: redefining persistent HIV-1 remission

Ezequiel Ruíz-Mateos

Elite controllers (EC) currently represent the only existing model of spontaneous virological remission in people with HIV (PWH) off antiretroviral treatment (ART). Therefore, understanding novel immunological and virological mechanisms that enable these remarkable individuals to achieve spontaneous control of the virus remains …

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The HIV reservoir landscape in elite controllers

Cristina Moral-Turón, María Antequera-Martínez, Ezequiel Ruíz-Mateos

PURPOSE OF REVIEW: In this review, we intend to define the main characteristics of the elite controller reservoir, exploring into its heterogeneity, which goes hand in hand with the different progression phenotypes within elite controllers. RECENT FINDINGS: Show that the viral reservoir …

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Impact of maternal stress and COVID-19 exposure during pregnancy on offspring neurodevelopment: signature cohort 12 month follow-up

Nathalia Garrido‐Torres, Andrés Román‐Jarrín, J. Alfred Rider, María Alemany-Navarro et autres

The COVID-19 pandemic brought unprecedented global challenges. Amid the crisis, the potential impact of COVID-19 exposure on the neurodevelopment of offspring born to infected mothers emerged as a critical concern. This is a prospective cohort study of pregnant women and their offspring …

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Plasmacytoid and CD141+ Myeloid Dendritic Cells Cooperation with CD8+ T Cells in Lymph Nodes is Associated with HIV Control

Joana Vitallé, Sara Bachiller, Beatriz Domínguez-Molina, Eirini Moysi et autres

Dendritic cells (DC) are known to modulate antiviral immune responses; however, the knowledge about the role of different DC subsets in antiviral T cell priming in human tissues remains uncompleted. In the context of HIV infection, we determined the phenotype and location …

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Dual role of circulating and mucosal Vδ1 T cells in the control of and contribution to persistent HIV-1 infection

Marie A. Iannone, Joana Vitallé, Marta Sanz, Brendan T. Mann et autres

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Maraviroc treatment for hospitalized participants with non-severe COVID-19 at risk of progression: a randomized, proof-of-concept clinical trial

Carmen Gasca‐Capote, José Manuel Lomas-Cabezas, Abraham Saborido-Alconchel, Cristina Moral-Turón et autres

BACKGROUND: Therapeutic options for hospitalized people with COVID-19 remain limited, especially for people with non-severe COVID-19 at risk of progression. The anti-inflammatory role of maraviroc, a CCR5 antagonists, makes it a good candidate for therapeutic strategies for COVID-19. METHODS: This was a …

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Dual role of circulating and mucosal Vδ1 T cells in the control of and contribution to persistent HIV-1 infection

Brendan T. Mann, Marta Sanz, Matthew L. Clohosey, Kayley Langlands et autres

Curative strategies for human immunodeficiency virus (HIV-1) infection are hindered by incomplete characterization of the latent reservoir and limited enhancement of anti-HIV immune responses. In this study, we identify a dual role for peripheral and tissue-resident Vδ1 T cells within the gastrointestinal …

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SARS-CoV-2 post-acute sequelae linked to inflammation via extracellular vesicles

Sara Bachiller, Joana Vitallé, Lluís Camprubí-Ferrer, Manuel Francisco Martínez García et autres

Background: Despite the efficacy of SARS-CoV-2 vaccines in reducing mortality and severe cases of COVID-19, a proportion of survivors experience long-term symptoms, known as post-acute sequelae of SARS-CoV-2 infection (PASC). This study investigates the long-term immunological and neurodegenerative effects associated with extracellular …

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HERC1 E3 Ubiquitin Ligase Is Necessary for Autophagy Processes and for the Maintenance and Homeostasis of Vesicles in Motor Nerve Terminals, but Not for Proteasomal Activity

Miguel A. Pérez‐Castro, Francisco Hernández-Rasco, Isabel M. Alonso-Bellido, María S. Letrán-Sánchez et autres

The ubiquitin proteasome system (UPS) is implicated in protein homeostasis. One of the proteins involved in this system is HERC1 E3 ubiquitin ligase, which was associated with several processes including the normal development and neurotransmission at the neuromuscular junction (NMJ), autophagy in …

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Persistent elite controllers as the key model to identify permanent HIV remission

Carmen Gasca‐Capote, Ezequiel Ruíz-Mateos

PURPOSE OF REVIEW: To summarize the heterogeneity in the elite controllers population with the aim to identify a compatible profile with a persistent HIV remission, making distinction between persistent elite controllers, people with HIV (PWHIV) who permanently maintain virological control in the …

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