Zhibo Han

Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation

Xiaotong Zhao, Kai Pan, Rui Li, Meina Liu et autres

Renal tubular epithelial cells (TECs), which are highly susceptible to injury during acute kidney injury (AKI), have notable regenerative effects on renal recovery after AKI. AKI-driven metabolic reprogramming of TECs plays a critical role in determining whether kidneys recover functionally or develop …

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Topical application of a placental mesenchymal stem cell-embedded biomaterial hydrogel accelerates the repair of radiation-induced skin damage: a double-blind randomized phase II clinical trial

Linghan Tian, Zhibo Han, Zhibo Han, Ming Jiang et autres

BACKGROUND: Radiation-induced skin injury (RSI) is a common complication of radiation therapy, that severely reduces the quality of life of patients, and there is currently no gold standard for treatment. Placental mesenchymal stem cells (PMSCs) have emerged as a promising therapeutic approach …

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Dissecting the heterogeneity and tumor-associated dynamics of human liver group I ILC via scRNA sequencing data

Yumo Zhang, Jitian He, Xue Li, Zhibo Han et autres

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Delivering LINE1 antisense oligonucleotides via endothelial targeting extracellular vesicles to ameliorate myocardial infarction-induced cardiac senescence

Enze Fu, Kai Pan, Benjamin Hinnant, Shang Chen et autres

Transposable elements (TEs) constitute a significant portion of the nuclear genome, but their influence on and ability to manage their activity during tissue regeneration remain largely unknown. Here, we revealed that LINE1, the most abundant TE, responds to cardiomyocyte injury and is …

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Salvage treatment of steroid-refractory acute GVHD with the off-the-shelf product of human umbilical cord mesenchymal stromal cells: a multicenter, open label, phase Ib/IIa trial

Yanmin Zhao, Yi Luo, Jimin Shi, Jian Yu et autres

Acute graft-versus-host disease (aGVHD) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly if treatment is refractory. Mesenchymal stromal cells (MSCs) have demonstrated promising therapeutic effects in aGVHD, due to their well-described immunomodulatory properties. Based on the importance of …

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Does a natural killer need a CAR?

Yumo Zhang, Zhibo Han, Youwei Wang

Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized cancer immunotherapy by overcoming intrinsic limitations in T cell activation, achieving remarkable success in treating relapsed or refractory hematologic malignancies in both pediatric and adult populations. Inspired by this success, researchers have turned …

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An optimized deterministic concurrency control approach for geo-distributed transaction processing on permissioned blockchains

Zhibo Han, Zeshun Peng, Gang Wang, Minghe Yu et autres

Concurrency control is crucial for ensuring consistency and isolation in distributed transaction processing. Traditional concurrency control algorithms, such as locking-based protocols, usually suffer from performance degradation due to heavy transaction coordination overheads. To overcome this problem, deterministic concurrency control approaches are widely …

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Aluminum exposure-exacerbated experimental colitis in mice was antagonized by Pueraria lobata extract

HuiYan Zhao, Fan Yang, Jie Pan, Liang Bai et autres

Aluminum is the most abundant environmental pollutant. Recent studies suggest that aluminum exposure increases the risk of multiple diseases, including intestinal barrier dysfunction. We investigated whether Pueraria lobata extract (PLE) is effective in safeguarding against aluminum chloride exposure-exacerbated intestinal barrier dysfunction. Using …

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Hyaluronic acid-modified extracellular vesicles for targeted doxorubicin delivery in hepatocellular carcinoma

Yue Liu, Benjamin Hinnant, Shang Chen, Hongyan Tao et autres

Hepatocellular carcinoma (HCC), a prevalent and deadly cancer, poses a significant challenge with current treatments due to limitations such as poor stability, off-target effects, and severe side effects. Extracellular vesicles (EVs), derived from tumor cells, have the remarkable ability to home back …

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Ligand‐Tethered Extracellular Vesicles Mediated RNA Therapy for Liver Fibrosis

Yue Liu, Shang Chen, Haoyan Huang, Adam C. Midgley et autres

Liver fibrosis poses a significant global health burden, in which hepatic stellate cells (HSCs) play a crucial role. Targeted nanomedicine delivery systems directed at HSCs have shown immense potential in the treatment of liver fibrosis. Herein, a bioinspired material, engineered therapeutic miR-181a-5p …

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WITHDRAWN: Mesenchymal Stem Cells in Clinical Trials for Immune Disorders

Zongjin Li, Zhibo Han

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Phosphatidylserine-mediated uptake of extracellular vesicles by hepatocytes ameliorates liver ischemia-reperfusion injury

Rongrong Li, Chen Wang, Xiaoniao Chen, Enze Fu et autres

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