Javier Afeltra

Isavuconazole Therapy for Patients with Hematologic Diseases and Hematopoietic Cell Transplantation with and Without Breakthrough Invasive Fungal Infections

Fabián Herrera, Diego Torres, Gustavo‐Adolfo Méndez, Noelia Mañez et autres

There are no data available on the effectiveness and safety of isavuconazole (ISA) for treating breakthrough invasive fungal infections (bIFIs). A retrospective and prospective cohort study was conducted between January 2020 and March 2025 in 13 centers in Argentina. Hematologic diseases (HD) …

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Isavuconazole Therapy for Patients with Hematologic Diseases and Hematopoietic Stem Cell Transplantation with and without Breakthrough Invasive Fungal Infections

Fabián Herrera, Diego Torres, Gustavo‐Adolfo Méndez, Noelia Mañez et autres

There are no data available on the effectiveness and safety of isavuconazole (ISA) for treating breakthrough invasive fungal infections (bIFIs). A retrospective and prospective cohort study was conducted between January 2020 and March 2025 in 13 centers in Argentina. Hematologic diseases (HD) …

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Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM

Oliver A. Cornely, Rosanne Sprute, Matteo Bassetti, Wen Chen et autres

Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidiasis primarily affect patients who are immunocompromised or critically ill. In contrast, mucocutaneous forms of candidiasis, …

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[Appropriate use of antimicrobials: knowledge, skills and learning preferences among Argentine medical students].

Pablo Gustavo Scapellato, Pedro Pessacq, Viviana E Rodriguez, Javier Afeltra et autres

INTRODUCTION: Antimicrobial resistance (AMR) is a growing global concern. Several studies have analyzed teaching methodologies and medical students' behavior regarding AMR. MATERIALS AND METHODS: We conducted a descriptive, observational, cross-sectional study (from April 1 to May 31, 2024) to assess perceptions, skills, …

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Clinical and Demographic Features of Paracoccidioidomycosis in Argentina: A Multicenter Study Analysis of 466 Cases

Gustavo Giusiano, Fernanda Tracogna, Gabriela Santiso, Florencia Dinorah Rojas et autres

Information on paracoccidioidomycosis (PCM) in Argentina is fragmented and has historically been based on estimates, supported only by a series of a few reported cases. Considering the lack of global information, a national multicentric study in order to carry out a more …

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Usefulness of Sōna Aspergillus Galactomannan LFA with digital readout as diagnostic and as screening tool of COVID-19 associated pulmonary aspergillosis in critically ill patients. Data from a multicenter prospective study performed in Argentina

Gustavo Giusiano, Norma Fernández, Roxana G. Vitale, Christian S. Álvarez et autres

COVID-19-associated pulmonary aspergillosis (CAPA) incidence varies depending on the country. Serum galactomannan quantification is a promising diagnostic tool since samples are easy to obtain with low biosafety issues. A multicenter prospective study was performed to evaluate the CAPA incidence in Argentina and …

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An overview of COVID-19 related to fungal infections: what do we know after the first year of pandemic?

Roxana G. Vitale, Javier Afeltra, Seyedmojtaba Seyedmousavi, S. L. Giudicessi et autres

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Current trends and future perspectives in infections due to emerging yeasts and molds difficult to treat

Javier Afeltra

A immunosuppressed patients has resulted in increasingly frequent diagnoses of invasive fungal infections, including unusual yeasts. The incidence of non-albicans species of Candida is increasing compared with that of Candida albicans. Trichosporon species are common cause of fungaemia in oncohaematological patients with …

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Differential distribution patterns of Fonsecaea agents of chromoblastomycosis, exemplified by the first case due to F. monophora from Argentina

Marcelo Gabriel Label, Luciana C. Karayan, Sybren de Hoog, Javier Afeltra et autres

Chromoblastomycosis is a mutilating infection of the skin and subcutaneous tissues caused by melanized fungi belonging to the order Chaetothyriales. Proven cases of the main agent, Fonsecaea pedrosoi are mainly limited to (sub)tropical, humid climates of Latin and Central America and the …

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N-haloacetyl phenothiazines and derivatives: Preparation, characterization and structure-activity relationship for antifungal activity

Gabriela P. Sarmiento, Maria Florencia Martini, Roxana G. Vitale, Lucas Fabián et autres

A serie of N-acetyl phenothiazines and related compounds was synthesized by means of the acetylation reaction of the corresponding phenothiazine with the appropriate reagent using microwave irradiation. Structural elucidation of these heterocyclic derivatives was done using 1H, 13C NMR spectra. The equilibra …

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CCDC 1550502: Experimental Crystal Structure Determination

Gabriela P. Sarmiento, Maria Florencia Martini, Roxana G. Vitale, Lucas Fabián et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 1550503: Experimental Crystal Structure Determination

Gabriela P. Sarmiento, Maria Florencia Martini, Roxana G. Vitale, Lucas Fabián et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …