William A. Clarke

Evaluating the impact of fentanyl immunoassay cutoff concentrations in emergency department, maternal, and neonatal populations

Maxwell L. Harsha, Kathryn Weaver, William A. Clarke, Ashley Rose Rackow

Qualitative urine drug screens (UDSs) are essential in clinical toxicology for assessments of drug exposure and are commonly employed by emergency departments to provide rapid results that inform care. Fentanyl, a potent synthetic opioid, is of significant public health concern due to …

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Analytical performance of an automated LC-MS/MS analyzer for determination of vitamin D concentration in blood plasma and serum

Katie Weaver, Tom de Waal, Michael Vogeser, Sven Grösgen et autres

Abstract Objectives Measurement of the concentrations of vitamin D metabolites is clinically important because abnormal levels are associated with perturbations in calcium and phosphorus homeostasis. The objective of this study was to evaluate analytical performance of the Ionify ® Vitamin D iPack …

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Real-world Use of Molecular Point-of-care Testing for Sexually Transmitted Infections (STIs) in the Emergency Department: Why It Matters for Acute Care Management

Gaby Dashler, Kendall Maliszewski, Mustapha O. Saheed, Edana Mann et autres

Abstract Background Point-of-care (POC) polymerase chain reaction (PCR) tests for sexually transmitted infections (STIs) represent a potential paradigm shift for emergency department (ED) management of patients with suspected STIs, given there are now Food and Drug Administration–cleared POC tests that permit definite …

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Randomized Clinical Trial of SARS-CoV-2 Peri-Vaccination Immunosuppressive Reduction in Kidney and Liver Transplant Recipients

William A. Werbel, Zeba Nauroz, Andrew H. Karaba, Diane M Brown et autres

Purpose: Solid organ transplant recipients (SOTRs) demonstrate weak antibody (Ab) response to SARS-CoV-2 vaccines despite repeated boosting. Immunosuppressive reduction (ISR) might improve responses, yet safety and immunogenicity are not established.

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Multicenter Evaluation of a New Strip-Based Blood Glucose System for Point-of-Care Testing in Critical and Non-Critical Care Settings

Michael D. Goodman, Sven Bercker, Nancy Breitenbeck, Cristina Cañada-Vilalta et autres

Background: Evaluation of the performance of Cobas ® Pulse (Roche Diagnostics GmbH, Mannheim, Germany), a new blood glucose (BG) monitoring system (BGMS; referred to here as BGMSA) intended for point-of-care testing using samples from patients in diverse clinical settings by intended point-of-care …

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Development and Application of the Modular MasSpec Pen System for Clinical Opioid Screening

Abigail N. Gatmaitan, Kathryn J. Weaver, Sunil P. Badal, H. Elizabeth Bird et autres

Mass spectrometry (MS) is an important tool for opioid screening due to the high analytical sensitivity and chemical specificity provided by MS for small molecule analysis. MS techniques that can provide direct detection of opioids are of high interest to simplify and …

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Case Series: Magnitude and duration of fentanyl and xylazine detection in the urine of persons with opioid use disorder

Helen Bird, William A. Clarke, Craig W. Hendrix, Kelly E. Dunn et autres

BACKGROUND/OBJECTIVES: The pharmacology of fentanyl and xylazine is not characterized in persons regularly exposed to illicit fentanyl. This case series presents individual-level urine pharmacokinetics of fentanyl, norfentanyl, and xylazine in persons with opioid use disorder (OUD). METHODS: Participants (N = 11) provided …

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Fentanyl and Xylazine Concentrations in Urine Predict Detection Times in Clinical Trial Participants

Helen Bird, William A. Clarke, Craig W. Hendrix, Melanie Baime et autres

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Identification of antibody targets associated with lower HIV viral load and viremic control

Wendy Grant‐McAuley, William R. Morgenlander, Ingo Ruczinski, Kai Kammers et autres

BACKGROUND: High HIV viral loads (VL) are associated with increased morbidity, mortality, and on-going transmission. HIV controllers maintain low VLs in the absence of antiretroviral therapy (ART). We previously used a massively multiplexed antibody profiling assay (VirScan) to compare antibody profiles in …

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Early, Robust Mucosal Secretory Immunoglobulin A but not Immunoglobulin G Response to Severe Acute Respiratory Syndrome Coronavirus 2 Spike in Oral Fluid Is Associated With Faster Viral Clearance and Coronavirus Disease 2019 Symptom Resolution

Nora Pisanic, Annukka A.R. Antar, Marissa K. Hetrich, Zoe O Demko et autres

BACKGROUND: Efforts are underway to support the development of novel mucosal coronavirus disease 2019 (COVID-19) vaccines. However, there is limited consensus about the complementary role of mucosal immunity in disease progression and how to evaluate immunogenicity of mucosal vaccines. This study investigated …

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Fentanyl Concentrations and Withdrawal in Illicit Fentanyl Exposure

Helen Bird, William A. Clarke, Melanie Baime, Prem Umang Satyavolu et autres

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A synthetic biology approach for the treatment of pollutants with microalgae

Luke J. Webster, Denys K. Villa Gomez, Reuben B. Brown, William A. Clarke et autres

The increase in global population and industrial development has led to a significant release of organic and inorganic pollutants into water streams, threatening human health and ecosystems. Microalgae, encompassing eukaryotic protists and prokaryotic cyanobacteria, have emerged as a sustainable and cost-effective solution …

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