Hitesh M. Goswami

Investigating the genomic landscape of sarcoma in India: Discoveries from a retrospective observational approach

Pramod S. Chinder, R. Veena, Mohamed Zehran, Amit Rauthan et autres

ABSTRACT Background: Due to the complex histological and genomic nature of sarcomas, diagnosing and treating them has proven challenging. Delving into the genomic profiles and molecular markers linked to different sarcoma subtypes will aid in overcoming these obstacles and identifying new potential …

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Deep Diving Into the Fusion Across Cancer Types in the Indian Population From Formalin-Fixed Paraffin-Embedded RNA-Exome Data: A Road to Discovering Novel Rearrangements With Clinical Relevance

Satya Prakash Khuntia, Nilesh Mukherjee, Vyomesh Javle, Nishtha Tanwar et autres

PURPOSE Gene fusions are critical oncogenic mutations that drive cancer development and serve as diagnostic and prognostic biomarkers. Despite the increasing cancer burden in India, large-scale analyses of molecular landscapes, particularly gene fusions, have been relatively scarce. MATERIALS AND METHODS This retrospective …

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Exploring the Role of Online Psycho-Oncology Counseling Interventions in Alleviating Distress among Cancer Patients

Jaitri Mandal, Rahul Kumar, Aditi Mukherjee, K Govindraj et autres

Objective: This study aims to evaluate the effectiveness of the Online Psycho-Oncology Counseling (OPC) in reducing distress levels among cancer patients. Methods: The research employs a paired sample t-test analysis to compare distress scores before and after the intervention. The study includes …

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Comprehensive Genomic Characterization of 1,200 Samples across 25 Cancer Types of Indian Ethnicity

Elveera Saldanha, Raunak Kumar, Sreekanth Reddy Peddagangannagari, Priyanka Pange et autres

*Corresponding author : (e-mail: pratikchandrani@gmail.com).

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Molecular insights from comprehensive genomic profiling data in advanced metastatic colorectal cancer in South Asian population: A retrospective observational study

Nusrath Fathima, Krithika Verma, Paridhy Vanniya Subramanyam, Nilesh Mukherjee et autres

ABSTRACT Background: An increase in colorectal cancer incidence has been reported in India, often presenting in advanced stages and resulting in poor survival. However, the genomic and therapeutic landscape is not well understood. Objective: The primary objective of the study was to …

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Exploring the clinical utility of liquid biopsy with cfDNA in cancer: A systematic review

Keerthi Ranganathan, Neethu Sheri Kurian, Hitesh M. Goswami, Kshitij D. Rishi et autres

Various tumor cells may exhibit different genetic or phenotypic characteristics. This phenomenon of cancer cells, known as Tumor Heterogeneity, is responsible for multiple cancer sites caused in a single patient through metastases. It is possible that the biopsy of the most accessible …

Authors’ reply to Weiner et al.

Vidya Veldore, Hitesh M. Goswami, Kshitij D. Rishi

We appreciate the critical review of our research,[1] and the interest shown by Weiner et al.[2] We acknowledge that the frequencies of homologous recombinant repair (HRR) mutations observed in our cohort were high, probably due to the fact that our study cohort …

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Pan-cancer analysis of the spectrum of homologous recombination DNA repair (HRR) pathway genes in the Indian population: A retrospective observational study

Nasreen Parween, Trisha Dutta Gupta, Paridhy Vanniya Subramanyam, Nishtha Tanwar et autres

Background: Homologous recombinant repair (HRR) deficit and the associated sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPi) has been well studied in breast, ovarian, prostate, and pancreatic cancers, but very little is known about it in other cancer types. Objectives: We sought to …

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Understanding the Impact of Population and Cancer Type on Tumor Mutation Burden Scores: A Comprehensive Whole-Exome Study in Cancer Patients From India

Nishtha Tanwar, Richa Malhotra, Aiswarya Padmaja Satheesh, Satya Prakash Khuntia et autres

PURPOSE: The purpose of this study was to understand the impact of population diversity and geographic variation on tumor mutation burden (TMB) scores across cancers and its implication on stratification of patients for immune checkpoint inhibitor (ICI) therapy. MATERIALS AND METHODS: This …

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An absolute approach to using whole exome DNA and RNA workflow for cancer biomarker testing

Richa Malhotra, Vyomesh Javle, Nishtha Tanwar, Pooja Gowda et autres

Introduction: The concept of personalized medicine in cancer has emerged rapidly with the advancement of genome sequencing and the identification of clinically relevant variants that contribute to disease prognosis and facilitates targeted therapy options. In this study, we propose to validate a …

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