Jana Tajtlová

Relationship between the occurrence of benign fasciculations, patient‘s psychological profile, biochemical parameters, and mutations in the SMN1 gene

Petr Ridzoň, Martina Langová, Renata Krejčí, Jana Tajtlová et autres

Complex karyotype and translocation t(4;14) define patients with high-risk newly diagnosed multiple myeloma: results of CMG2002 trial

Pavel Němec, Zuzana Zemanová, Petr Kuglík, Kyra Michalova et autres

The prognostic impact of chromosomal abnormalities was evaluated by fluorescence in situ hybridization with cytoplasmic immunoglobulin light chain staining (cIg-FISH) and by classical metaphase cytogenetics in a cohort of 207 patients with newly diagnosed multiple myeloma who were treated with high-dose therapy …

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Gain of 1q21 Is an Unfavorable Genetic Prognostic Factor for Multiple Myeloma Patients Treated with High-Dose Chemotherapy

Pavel Němec, Zuzana Zemanová, Henrieta Grešlíková, Kyra Michalova et autres

The prognostic significance of 1q21 gain, del(13)(q14), del(17)(p13), t(4;14)(p16.3;q32), and t(11;14)(q13;q32) detected by interphase fluorescein in situ hybridization (FISH) was studied in a cohort of 91 patients with newly diagnosed multiple myeloma (MM). 1q21 gain was detected in 37 of 91 patients …

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Combined molecular biological and molecular cytogenetic analysis of genomic changes in 146 patients with B-cell chronic lymphocytic leukemia.

Adéla Berková, Lenka Pavlištová, Libuše Babická, Lucie Houšková et autres

Interphase fluorescence in situ hybridization was used to detect common deletions in B-CLL patients as well as trisomy 12 and aberrations of IgH gene complex at 14q32.33 where we evaluated not only translocation-like signal pattern but also deletions. 120 (82%) patients showed …

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Molekulárně cytogenetická analýza imunofluorescenčně značenýchplazmatických buněk u pacientů s mnohočetným myelomem ve studiiCMG 2002

Milena Holzerová, Zuzana Zemanová, Kyra Michalova, Jana Tajtlová et autres

Výsledky molekulárně cytogenetické analýzy imunofluorescenčněznačených plasmatických buněk u pacientů s MM zařazených vestudii CMG 2002

Zuzana Zemanová, Kyra Michalova, Jana Tajtlová, Lenka Pavlištová et autres

V letech 2004-2006 jsme u 208 nemocných s MM zařazených do studie CMG 2002 vysetřili imunofluorescencně znacene plasmaticke buňky metodou cIg-FISH. Sledovali jsme frekvenci a prognostický význam specifických chromosomových aberaci. U 52.9% pacientů jsme detekovali aberace chromosomu 13, přestavby IgH genu jsme …

Molecular cytogenetic study of immunofluerescently labeledplasma cells and prognostic significance of clonal chromosomalaberrations in 208 Patients with multiple myeloma

Zuzana Zemanová, Kyra Michalova, Jana Tajtlová, J. Pavlištová et autres

Gain/amplification of 1q21 is the most powerful geneticprognostic factor for patients treated by autologous stem celltransplantation

Pavel Němec, Zuzana Zemanová, Kyra Michalova, Jana Tajtlová et autres

Our data suggest that gain1q21 is associated with reduced PFS and OS intervals in patients treated with autologous transplantation. Similarly a trend towards shorter survival for del17p13 positive patients was observed. Moreover, negative prognostic impact of gain1q21 can be boosted by presence …

Molecular Cytogenetic Study of Immunofluorescently Labeled Plasma Cells and Prognostic Significance of Clonal Chromosomal Aberrations in Multiple Myeloma.

Kyra Michalova, Zuzana Zemanová, Lenka Pavlištová, Jana Tajtlová et autres

Abstract Finding of clonal chromosomal aberrations in plasma cells is considered as one of the most important and independent prognostic factor in patients with multiple myeloma (MM). The most frequent and reliable cytogenetic indicators are chromosome 13q deletions (intermediate or moderately adverse …

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