Gurranna Male

Mediator Tail Subunits Hierarchically Couple Transcriptional Condensates to Gene Activation and Genome Organization

Gurranna Male, Suman Mohajan, Linda S Rubio, David S. Gross

Abstract Cells respond to acute environmental stress by rapidly reorganizing transcriptional machinery and genome architecture, yet how these processes are mechanistically integrated remain poorly understood. We find that Mediator Tail subunits function in a hierarchical fashion to coordinate transcription factor condensate assembly, …

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Neutrophil CD14 is a driver and a therapeutic target for deep vein thrombosis

Nilesh Pandey, Harpreet Kaur, Raktim Mitra, Lakshmi Chandaluri et autres

ABSTRACT: Neutrophil-mediated persistent inflammation and neutrophil extracellular trap formation (NETosis) are critical in the pathogenesis of deep vein thrombosis (DVT). Identifying the mechanisms controlling these proinflammatory and prothrombotic functions is critical for designing and developing new therapeutics for DVT. However, how neutrophils …

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Author response: Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

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Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes a …

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Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

Abstract The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes …

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Author response: Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes a …

Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

Abstract The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes …

de, es, us (code pays fourni par la source)

Author response: Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes a …

Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes a …

de, es, us (code pays fourni par la source)

Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

Abstract The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes …

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The challenge of staying in shape: nuclear size matters

Pallavi Deolal, Gurranna Male, Krishnaveni Mishra

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Nucleolar size regulates nuclear envelope shape in Saccharomyces cerevisiae

Gurranna Male, Pallavi Deolal, Naresh Kumar Manda, Shantam Yagnik et autres

ABSTRACT Nuclear shape and size are cell-type specific. Change in nuclear shape is seen during cell division, development and pathology. The nucleus of Saccharomyces cerevisiae is spherical in interphase and becomes dumbbell shaped during mitotic division to facilitate the transfer of one …

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