David S. Gross

Mediator Tail Subunits Hierarchically Couple Transcriptional Condensates to Gene Activation and Genome Organization

Gurranna Male, Suman Mohajan, Linda S Rubio, David S. Gross

Abstract Cells respond to acute environmental stress by rapidly reorganizing transcriptional machinery and genome architecture, yet how these processes are mechanistically integrated remain poorly understood. We find that Mediator Tail subunits function in a hierarchical fashion to coordinate transcription factor condensate assembly, …

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Transcriptional condensates and the nuclear pore complex regulate gene expression and 3D genome architecture in response to stress

Suman Mohajan, David S. Gross

Cells respond to thermal, chemical, and oxidative stress by activating an evolutionarily conserved adaptive mechanism known as the heat shock response (HSR) that maintains protein homeostasis and ensures cell survival. Central to the HSR is Heat Shock Factor 1 (HSF1), a highly …

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Author response: Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

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Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes a …

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Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

Abstract The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes …

de, es, us (code pays fourni par la source)

Author response: Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes a …

Nuclear basket proteins Nup2 and Mlp1 drive heat shock–induced 3D genome restructuring downstream of transcriptional activation

Suman Mohajan, Linda S Rubio, David S. Gross

The nuclear pore complex (NPC), a multisubunit complex located within the nuclear envelope, regulates RNA export and the import and export of proteins. Here, we address the role of the NPC in driving thermal stress-induced 3D genome repositioning of heat shock-response (HSR) …

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Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

Abstract The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes …

de, es, us (code pays fourni par la source)

Author response: Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes a …

Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes a …

de, es, us (code pays fourni par la source)

Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava et autres

Abstract The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs). Saccharomyces cerevisiae encodes …

de, es, us (code pays fourni par la source)

Nuclear Basket Proteins Mlp1 and Nup2 Drive Heat Shock–Induced 3D Genome Restructuring

Suman Mohajan, Linda S Rubio, David S. Gross

The nuclear pore complex (NPC), a multisubunit complex located within the nuclear envelope, regulates RNA export and the import and export of proteins. Here we address the role of the NPC in driving thermal stress-induced 3D genome repositioning of _Heat Shock Responsive_ …

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