Iuri Martin Goemann

The Brazilian Transition in Differentiated Thyroid Carcinoma Management: A 25-Year Nationwide Analysis of Declining High-Activity Radioiodine Use (2000-2024)

José Miguel Dora, Leonardo Barbi Walter, André Borsatto Zanella, Iuri Martin Goemann et autres

OBJECTIVE: To analyze temporal trends in radioiodine (RAI) prescription patterns for differentiated thyroid carcinoma (DTC) in Brazil from 2000 to 2024, assessing adherence to evolving clinical guidelines and identifying opportunities for practice optimization. MATERIALS AND METHODS: This retrospective study utilized data from …

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Reciprocal cancer risks between thyroid and breast cancer: a systematic review and meta-analysis

Patrícia Pacheco Viola, Matheus Wohlfahrt Baumgarten, Dimitris Rucks Varvaki Rados, Lucilene Arilho Ribeiro et autres

Thyroid cancer (TC) and breast cancer (BC) are common in females, with growing evidence of their higher-than-expected co-occurrence. The purpose of this systematic review and meta-analysis was to evaluate the relationship between TC and BC and to examine the likelihood of developing …

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Distinct transcriptional and prognostic impacts of TERT promoter mutations C228T and C250T in papillary thyroid carcinoma

Vicente Rodrigues Marczyk, Ana Luiza Maia, Iuri Martin Goemann

TERT promoter mutations C228T and C250T are associated with disease aggressiveness and poor clinical outcomes in patients with papillary thyroid carcinomas. However, very little is known about the transcriptional consequences of these mutations and whether they both carry similar oncogenic potential. Here …

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Survival Outcomes in Thyroid Cancer Patients with Co-Occurring Breast Cancer: Evidence of Mortality Risk Attenuation

Matheus Wohlfahrt Baumgarten, Iuri Martin Goemann, Rafael Selbach Scheffel, Ana Luiza Maia

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Age-related variation in malignant cytology rates of thyroid nodules: insights from a retrospective observational study assessing the ACR TI-RADS

Leonardo Barbi Walter, Paula Martins Fernandes, Débora Lunkes Strieder, Anita Lavarda Scheinpflug et autres

OBJECTIVE: The influence of age on the malignant cytology rate of thyroid nodules remains uncertain. The American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) is currently used to guide subsequent investigations of thyroid nodules, regardless of clinical variables. …

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Classification of Thyroid Tumors Based on DNA Methylation Patterns

Vicente Rodrigues Marczyk, Mariana Recamonde‐Mendoza, Ana Luiza Maia, Iuri Martin Goemann

Background:Alterations in DNA methylation are stable epigenetic events that can serve as clinical biomarkers. The aim of this study was to analyze methylation patterns among various follicular cell-derived thyroid neoplasms to identify disease subtypes and help understand and classify thyroid tumors. Methods:We …

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Rat-tailed maggot urinary myiasis

Nicolas Peruzzo, Ricardo Siegle, Rafael Drevs Tesche, Gustavo Gössling et autres

A 32-year-old woman from South Brazil presented to the emergency department after passing a 1.5-cm living organism during micturition, which was collected and brought for analysis (Figure 1, Supplementary Video 1). She had developed intense dysuria and suprapubic tenderness a few days …

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Wheezing in an Asthmatic Woman: Worsening Asthma or Something Else?

Nicolas Peruzzo, Gustavo Gössling, Rodrigo da Silva Muller, Iuri Martin Goemann

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Contributors

Ambika P. Ashraf, Farahnak Assadi, Thomas M. Barber, Filippo Ceccato et autres

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Pheochromocytomas and hypertension

Iuri Martin Goemann, Ana Luiza Maia

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DNA methylation patterns define subtypes of differentiated follicular cell-derived thyroid neoplasms: an unsupervised machine learning approach

Vicente Rodrigues Marczyk, Mariana Recamonde‐Mendoza, Ana Luiza Maia, Iuri Martin Goemann

Abstract Alterations in DNA methylation patterns are a frequent finding in cancer. Methylation aberrations can drive tumorigenic pathways and serve as potential biomarkers. The role of epigenetic alterations in thyroid cancer is still poorly understood Here, we analyzed methylome data of a …

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Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated with Cognitive Impairment in Older Adults: A Cross-Sectional Study

Wallace Klein Schwengber, Vitor Bock Silveira, Guilherme Moreira Hetzel, Amanda Robaina et autres

Background: Type 2 Deiodinase (DIO2) converts thyroxine (T4) into the active hormone triiodothyronine (T3). Thr92Ala DIO2 polymorphism has been associated with reduced conversion of T4 into T3 and central nervous system hypothyroidism. However, how Thr92Ala DIO2 polymorphism affects cognitive function is still …

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