Anton Jan van Zonneveld

Y-RNAs and their fragments reflect kidney injury in diabetic kidney disease

Zhao Qiao, Yunyi Liang, Rudmer Postma, Jacques M.G.J. Duijs et autres

Diabetic kidney disease (DKD) affects one-third of patients with diabetes mellitus (DM). Y-RNAs (RNYs) are a type of highly abundant non-coding RNA that could potentially serve as disease biomarkers. This study investigated whether circulating RNYs associate with DKD that may facilitate early …

nl, cn (code pays fourni par la source)

Dipstick urinary chloride as a surrogate marker of urinary sodium in cirrhosis: a prospective multicenter pilot study

Susan E. Fischer, Britt van Ruijven, Annarein Kerbert, Marta Fiocco et autres

BACKGROUND: Reduced urinary sodium excretion reflects disease severity in patients with cirrhosis, but routine use outside clinical settings is not feasible. Urinary chloride, reabsorbed alongside sodium, can be easily measured using a dipstick. This study examines the correlation between dipstick-measured urine chloride …

nl (code pays fourni par la source)

sncRNA levels predict SNORD105B is a novel biomarker of chronic kidney disease risk and SGLT2 inhibitor response in type 2 diabetes

Juliette A. de Klerk, Roderick C. Slieker, Joline W.J. Beulens, Janneke H D Peerlings et autres

Chronic kidney disease (CKD) is a common complication of type 2 diabetes, characterized by reduced kidney function and/or albuminuria, yet its progression varies widely among individuals. While sodium-glucose cotransporter-2 (SGLT2) inhibitors are known to protect against kidney decline, the molecular mechanisms underlying …

nl (code pays fourni par la source)

THU-436 Urinary chloride dipstick as a potential biomarker for predicting decompensation in patients with cirrhosis: a prospective multicenter pilot study

Susan Fischer, Britt van Ruijven, Annarein Kerbert, Marta Fiocco et autres

SAT-467-YI Geographical variation in rifaximin use, gut microbiota composition, and outcomes in european patients with decompensated cirrhosis

Susan Fischer, Josune Cabello Calleja, Felix Salim, Wenyi Gu et autres

Albumin Restores Endothelial Cell Mitochondrial Morphology in Patients With Decompensated Cirrhosis

Susan E. Fischer, Rudmer J. Postma, Roel Bijkerk, Annarein Kerbert et autres

BACKGROUND & AIMS: Endothelial cell (EC) activation is a critical driver of disease progression in cirrhosis, contributing to acute decompensation (AD) and acute-on-chronic liver failure (ACLF). Although human albumin administration improves EC function in cirrhotic patients with hypoalbuminemia, its direct effects on …

nl (code pays fourni par la source)

N-methyl-D-aspartate receptor inhibition protects against obesity-induced kidney disease

Àuria Eritja, Catalina Pérez-Olives, Dariel A Rodríguez Falcón, Maite Caus et autres

BACKGROUND: Obesity-associated nephropathy is becoming increasingly prevalent, yet the molecular mechanisms linking metabolic stress to renal dysfunction remain unclear. N-methyl-D-aspartate receptors (NMDARs) are expressed in the kidney and are involved in the pathogenesis of different renal diseases. This study aimed to explore …

es, nl (code pays fourni par la source)

Exploring the link between disturbed flow and endothelial cell function in an in vitro arteriovenous fistula model

Zhuotao Xiao, Nicholas A. White, Jun Wen, Rudmer J. Postma et autres

BACKGROUND: The disturbed flow contributes to juxta-anastomotic intimal hyperplasia (IH) in arteriovenous fistulas (AVFs). This study developed an in vitro method aiming to understand the hemodynamic impact on endothelial cells (ECs) in AVFs. METHODS: A tubular bifurcation AVF model was constructed, and …

nl, cn, us (code pays fourni par la source)

Development and patterns of acute-on-chronic liver failure in patients with cirrhosis and acute kidney injury

Susan E. Fischer, Martin Sebastian McCoy, Marta Fiocco, Annarein Kerbert et autres

Background & Aims: The prevalence and evolution of acute-on-chronic liver failure (ACLF), particularly extrarenal organ failures, in patients with cirrhosis and acute kidney injury (AKI) are not well characterized. This study investigated the development and progression of ACLF in patients with cirrhosis …

nl, de (code pays fourni par la source)

RNA-based therapeutic opportunities for the treatment of kidney diseases

Jurriën Prins, Annabelle Biscans, Anton Jan van Zonneveld, Kendall S. Frazier et autres

nl, jp, fi, us (code pays fourni par la source)

Targeting microRNA-132 protects against kidney fibrosis and restricts myofibroblast differentiation from cells of renin lineage

Loïs A.K. van der Pluijm, Angela Koudijs, Jacques M.G.J. Duijs, Wendy Stam et autres

This study demonstrates that cells of renin lineage (CoRL) directly contribute to the myofibroblast pool in two distinct models of kidney injury. Silencing of microRNA-132 reduces kidney fibrosis, preserves podocyte number, and attenuates myofibroblast proliferation, including those derived from CoRL. These findings …

nl (code pays fourni par la source)

Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function

Juliette A. de Klerk, Roderick C. Slieker, Hao Wu, Yoshiharu Muto et autres

Long non-coding RNAs (lncRNAs) play essential roles in cellular processes, often exhibiting cell type-specific expression and influencing kidney function. While single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cellular specificity, past studies focus solely on protein-coding genes. We hypothesize that lncRNAs, …