Targeting microRNA-132 protects against kidney fibrosis and restricts myofibroblast differentiation from cells of renin lineage

Résumé fourni par la source

This study demonstrates that cells of renin lineage (CoRL) directly contribute to the myofibroblast pool in two distinct models of kidney injury. Silencing of microRNA-132 reduces kidney fibrosis, preserves podocyte number, and attenuates myofibroblast proliferation, including those derived from CoRL. These findings highlight miR-132 as a promising target to curb fibrotic remodeling while preserving renal structure and uncover new insights into the dual regenerative and profibrotic plasticity of CoRL.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.