Ikechi Ozoemelam

A preference‐integrated optimization system for medical physics shift scheduling

Benjamin S. Rosen, Zheng Zhang, Karolyn M. Hopfensperger, Kelly C. Paradis et autres

BACKGROUND: Clinical shift scheduling for medical physicists is challenging given multidisciplinary roles and competing clinical, research, and service demands. Manual workflows often lack the flexibility and transparency needed for this complex field. PURPOSE: To develop, deploy, and evaluate a preference-driven, optimization-based scheduling …

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A preclinical setup for FLASH radiotherapy beam delivery at isocenter using downstream electron scattering

Ikechi Ozoemelam, Rowan Paplanus, Michael Pillainayagam, Donald A. Roberts et autres

BACKGROUND: Preclinical investigations have shown that ultra-high dose rate (UHDR) radiotherapy (>40 Gy/s) also known as FLASH-RT, reduces normal tissue toxicity while preserving tumor control efficacy compared to conventional dose rate treatments. Achieving a UHDR-capable LINAC requires modifications including modifications to electron …

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A kV–MV approach to CBCT metal artifact reduction using multi-layer MV-CBCT

Matthew W. Jacobson, Thomas C. Harris, Marios E. Myronakis, Mathias Lehmann et autres

Abstract Objective . To demonstrate that complete cone beam CT (CBCT) scans from both MV-energy and kV-energy LINAC sources can reduce metal artifacts in radiotherapy guidance, while maintaining standard-of-care x-ray doses levels. Approach . MV-CBCT and kV-CBCT scans are acquired at half …

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Monte Carlo model of a prototype flat‐panel detector for multi‐energy applications in radiotherapy

Ikechi Ozoemelam, Marios E. Myronakis, Thomas C. Harris, Pablo Corral Arroyo et autres

Abstract Background The incorporation of multi‐energy capabilities into radiotherapy flat‐panel detectors offers advantages including enhanced soft tissue visualization by reduction of signal from overlapping anatomy such as bone in 2D image projections; creation of virtual monoenergetic images for 3D contrast enhancement, metal …

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Impact of a novel multilayer imager on metal artifacts in MV-CBCT

Thomas C. Harris, Matthew W. Jacobson, Marios E. Myronakis, Mathias Lehmann et autres

Abstract Objective . Megavoltage cone-beam computed tomography (MV-CBCT) imaging offers several advantages including reduced metal artifacts and accurate electron density mapping for adaptive or emergent situations. However, MV-CBCT imaging is limited by the poor efficiency of current detectors. Here we examine a …

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Precision of the PET activity range during irradiation with 10 C, 11 C, and 12 C beams

Daria A. Kostyleva, S. Purushothaman, Peter G. Dendooven, E. Haettner et autres

Abstract Objective . Beams of stable ions have been a well-established tool for radiotherapy for many decades. In the case of ion beam therapy with stable 12 C ions, the positron emitters 10,11 C are produced via projectile and target fragmentation, and …

de, nl, jp, cn (code pays fourni par la source)

Author Correction: Proton range verification with MACACO II Compton camera enhanced by a neural network for event selection

Enrique Muñoz, Ana Ros, Marina Borja-Lloret, John Barrio et autres

Barrio, J. et al. Performance improvement tests of MACACO: a Compton telescope based on continuous crystals and SiPMs. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment (2017).

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Real-time positron emission imaging for range verification in helium beam radiotherapy

Peter G. Dendooven, Ikechi Ozoemelam, E.R. van der Graaf, Marc Jan van Goethem et autres

Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI

Daria Boscolo, Daria A. Kostyleva, Mohammad Javad Safari, Vasiliki Anagnostatou et autres

Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of …

de, fi, in, nl, jp, at, cn (code pays fourni par la source)

Proton range verification with MACACO II Compton camera enhanced by a neural network for event selection

Enrique Muñoz, Ana Ros, Marina Borja-Lloret, John Barrio et autres

Abstract The applicability extent of hadron therapy for tumor treatment is currently limited by the lack of reliable online monitoring techniques. An active topic of investigation is the research of monitoring systems based on the detection of secondary radiation produced during treatment. …

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Real-Time PET Imaging for Range Verification of Helium Radiotherapy

Ikechi Ozoemelam, E.R. van der Graaf, Marc‐Jan van Goethem, Maciej Kapusta et autres

Real-time range verification of particle beams is important for optimal exploitation of the tissue-sparing advantages of particle therapy. Positron Emission Tomography (PET) of the beam-induced positron emitters such as 15O (T1/2 = 122 s) and 11C (T1/2 = 1218 s) has been …

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Real-time positron emission tomography for range verification of particle radiotherapy

Ikechi Ozoemelam

Owing to the superior ability to deliver the prescribed radiation dose to cancer tissue with a reduced dose to surrounding healthy tissues, there has been a sustained increase in cancer radiotherapy with charged particles, such as protons, helium and carbon ions. Achieving …