Marc‐Jan van Goethem

FAST DEGRADER FOR FLASH HADRON THERAPY IRRADIATIONS

Atia Ibrahimi, Stefan Both, Marc‐Jan van Goethem, Rob Kremers et autres

FLASH effect tissue sparing comparison for X-ray, hadron, and VHEE irradiation modalities

Atia Ibrahimi, Stefan Both, Marc‐Jan van Goethem, Francesco Romano et autres

FLASH-RT is an irradiation modality using Ultra-High-Dose-Rates, where a healthy tissue sparing effect is observed. Different particle types have distinct characteristics in lateral and distal dose deposition, which can affect the amount of healthy tissue sparing by the FLASH effect. However, few …

nl, it, gb (code pays fourni par la source)

Advanced image processing for accurate proton radiography with a scintillator screen coupled with a CCD camera: Geant4 simulations and experiments with a two-material phantom

Francesco Olivari, Marc‐Jan van Goethem, S. Brandenburg, E.R. van der Graaf

Purpose Measurement of the proton water-equivalent path length (WEPL) and relative stopping power (RSP) of human tissues with proton radiography (pRG) can help improving the X-ray-CT-based RSP images of patients in proton-therapy treatment plans. This paper presents an extension to cylindrical symmetric …

nl (code pays fourni par la source)

Differential synaptic signaling responses in human cortical organoids after photon and proton irradiation

Yuting Jiang, Danieli Born Guerra, Daniëlle C. Voshart, Eline Hageman et autres

Brain tumors are the most common solid cancer in children, with radiotherapy being a primary treatment. Proton therapy, with its precise dose distribution, is increasingly being used in these patients to minimize damage to the developing brain. However, the biological effects of …

nl (code pays fourni par la source)

Replication Data for: FLASH effect tissue sparing comparison for X-Ray, hadron, and VHEE irradiation modalities

Atia Ibrahimi, Stefan Both, Marc‐Jan van Goethem, Francesco Romano et autres

This dataset contains input files for Topas MC Monte Carlo simulations, the corresponding output data from these simulations, and Python scripts for post-processing and analysis. It is intended to support reproducibility of the study and facilitate further research by providing ready-to-use scripts …

nl (code pays fourni par la source)

VERIFICATION OF LETD OPTIMIZED IMPT PLANS IN A CIRS 731-HN PHANTOM USING AN SOI MICRODOSIMETER

Vladimir A. Pan, Linh T. Tran, James Vohradsky, Dirk Wagenaar et autres

au, nl, us (code pays fourni par la source)

A MONTE CARLO FRAMEWORK FOR ROBUST PROTON CONFORMAL FLASH IRRADIATION OF ECTOPIC MAMMARY TUMORS IN MICE

Jeremy P Gunawan, Lara Barazzuol, Marc‐Jan van Goethem, Robert Paul Coppes et autres

nl (code pays fourni par la source)

Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage

Davide Cinat, Rufina Maturi, Jeremy P Gunawan, Anne L. Jellema-de Bruin et autres

Organoid models have significantly enhanced our understanding of adult stem cell function, however, uncovering regulatory mechanisms governing rare and often quiescent stem cells in glandular organs remains challenging. Here, we employ an integrative multi-omics approach, combining single-cell RNA sequencing, bulk ATAC and …

nl, us, it, at, ca (code pays fourni par la source)

Feasibility study of a compact proton-radiography system based on a scintillator screen

Francesco Olivari, Marc‐Jan van Goethem, Sytze Brandenburg, E.R. van der Graaf

PURPOSE: Proton radiography may reduce the range uncertainties affecting proton therapy if it can provide 1% accurate water-equivalent path lengths (WEPL) or relative stopping powers (RSP) of tissues. In a Monte-Carlo study, we showed that such an accuracy can in theory be …

nl (code pays fourni par la source)

Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations

Jeremy P Gunawan, Hans Peters, Johan Bussink, Lara Barazzuol et autres

while controlling oxygen levels. Here, we developed a hypoxia system for high-throughput irradiations that accommodates embedded 3D cultures, such as organoids and spheroids, enabling the study of the effect of oxygen on radiation responses.

nl (code pays fourni par la source)

Notch Signaling Drives Pro-Regenerative and Migratory Traits in Glandular Stem/Progenitor cells

Davide Cinat, Rufina Maturi, Jeremy P Gunawan, Anne L. Jellema-de Bruin et autres

Abstract Organoid models have advanced our understanding of adult stem/progenitor cell dynamics and function. However, uncovering the regulatory mechanisms of scarce and often quiescent stem cells in organs like the salivary glands remains challenging. Using single-cell RNA sequencing and bulk ATAC and …

nl, it, at, cn (code pays fourni par la source)

Sparing of the Heart Facilitates Recovery From Cardiopulmonary Side Effects After Thoracic Irradiation

Julia Wiedemann, Sai K Paruchuru, Lisette E. den Boef, Uilke Brouwer et autres

PURPOSE: When irradiating thoracic tumors, dose to the heart or lung has been associated with survival. We previously showed in a rat model that in addition to known side effects such as pericarditis, pneumonitis and fibrosis, heart and/or lung irradiation also impaired …

nl (code pays fourni par la source)