Naoki Nanashima

Differential Effects of Cultural Performing Arts on Anti-Aging Biomarkers and Well-Being: A Non- Randomized Pre–Post Comparative Study of Traditional Noh/Kyogen and Comedy

Toshiko Tomisawa, Naoki Nanashima, Naoya In, Kayo Horie et autres

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Apple pomace extract induces type II collagen and proteoglycan production in human chondrocytes

Naoki Nanashima, H. Maeda, Akira Nakajima, Makoto Nishizuka et autres

Apple pomace, an agricultural by-product, is rich in bioactive components; however, its effects on chondrocyte function remain unclear. We investigated the effects of apple pomace extract (APE) on the human chondrosarcoma-derived cell line OUMS-27. APE treatment markedly increased type II collagen and …

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Stress-reducing effect of laughter in live comedy performance from salivary α-amylase and salivary oxytocin

Kayo Horie, Naoki Nanashima, Naoya In, Toshiko Tomisawa

OBJECTIVE: Laughter is recognized for its potential to alleviate stress. Salivary α-amylase (sAA) is a well-known stress marker; however, the relationship between salivary oxytocin (sOXT) and stress reducing effects by laughter remains unclear. We previously determined the relationship between laughter and optimism, …

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Oxaloacetate and Ketone Bodies Synergistically Promote Myoblast Differentiation in L6 Cells

Naoki Nanashima, Yutaro Sasaki, Akiko Kojima‐Yuasa, Toshio Norikura

Malnutrition and aging are major factors that inhibit myoblast differentiation, leading to a decline in muscle function and contributing to sarcopenia development. This study aimed to elucidate the role of nutrients in myoblast differentiation by establishing a culture system at physiological glucose …

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Unlocking optimism in everyday life: a short-term study on the power of live comedy to reduce stress and anxiety in general public

Toshiko Tomisawa, Kayo Horie, Naoya In, Naoki Nanashima et autres

Background: Although there have been many studies on laughter and health, few studies have clarified the effects of laughter on optimism and pessimism, as well as anxiety. The purpose of the study was to evaluate the effects of viewing a comedy live …

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Total synthesis of quasi-symmetric dihydrofuran lignans (−)-ribesin A and B isolated from Ribes nigrum leaves

Kae Horio, H. Maeda, Kayo Horie, Naoki Nanashima et autres

Dihydrofuran lignans ribesin A ( 1 ) and ribesin B ( 2 ) isolated from Ribes nigrum leaves were chemically synthesized for the first time using oxa-Michael addition–carbocyclization and double-bond migration as key steps. However, the NMR data of synthesized ribesin B …

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Total Synthesis of Quasi-Symmetric Dihydrofuran Lignans (−)-Ribesin a and B Isolated from Ribes Nigrum Leaves

Kae Horio, H. Maeda, Kayo Horie, Naoki Nanashima et autres

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Effect of apple pomace extract on human skin fibroblasts

Naoki Nanashima, Hayato Maeda, Akira Nakajima, Makoto Nishizuka et autres

【目的】ヒト皮膚線維芽細胞（HSF）は真皮層に存在し，皮膚の美容に関連するコラーゲンやヒアルロン酸などを産生する細胞である．リンゴ搾汁残渣はリンゴジュースの製造の際に生じるが，その大半は廃棄されている．リンゴ搾汁残渣には，トリテルペンなどの機能性成分が含まれており，ヒトの健康に様々な有益な効果をもたらすことが報告されているが，皮膚美容に対する効果についての研究例はない．そこで本研究では，リンゴ搾汁残渣抽出物（APE）がHSFに及ぼす影響を解析した．

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Silencing of ERRα gene represses cell proliferation and induces apoptosis in human skin fibroblasts

Naoki Nanashima, Toshio Norikura, Manabu Nakano, Chie Hata et autres

Estrogen‑related receptor (ERR) is an orphan nuclear receptor structurally akin to the estrogen receptor. ERR is expressed in tissues with active energy metabolism and regulates intracellular metabolic functions. Additionally, ERRs are known to be strongly expressed in the epidermis of skin tissue, …

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Detecting Phytoestrogens and Mammalian Estrogens in Blackcurrants (Ribes nigrum)

Naoki Nanashima, Kayo Horie, H. Maeda

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Apple Pomace Extract Induces Cell Proliferation and Increases Type I Collagen and Hyaluronan Production in Human Skin Fibroblasts In Vitro

Naoki Nanashima, H. Maeda, Akira Nakajima, Makoto Nishizuka et autres

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Blackcurrant extract promotes differentiation of MC3T3‑E1 pre‑osteoblasts

Naoki Nanashima, Kayo Horie, Indrawati Oey

Osteoporosis risk increases in menopausal individuals owing to the decrease in estrogen secretion. Blackcurrant extract (BCE) ameliorates osteoporosis; however, the underlying mechanisms are unclear. Furthermore, although BCE has phytoestrogenic activity, its effects on osteoblasts are unknown. In the present study, we investigated …

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