Desheng Lu

A multifunctional eutectogel with anti-freezing, antibacterial, and adhesive properties for cardiac health monitoring and machine learning-assisted identification

Yaohan Tang, Dongyan Liang, Naiqian Sa, Xiuyuan Liang et autres

cn (code pays fourni par la source)

Precise control of launch velocity vector for cold atomic cloud based on moving optical molasses

Yao Li, Zhiyi Liu, Yu Hu, Jingfeng Xiang et autres

We propose a method for precise control of the launch velocity vector of a cold atomic cloud. By independently adjusting the relative detuning of three pairs of orthogonal counter-propagating laser beams in moving optical molasses, this method achieves accurate regulation of three-dimensional …

cn (code pays fourni par la source)

Chronic wound infection caused by Phialophora americana

Wanhong Huang, Desheng Lu, Zerong Lu, Xiaocheng Luo

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The association of the Wnt/β-catenin signaling pathway with Alzheimer's disease

Jiaying Ma, Yi Liu, Desheng Lu, Qi Sun

With the global rise in population aging, the incidence of Alzheimer's disease (AD) continues to increase, posing a substantial burden on individuals, families, and healthcare systems. However, at present, the drugs approved by FDA for treating AD can only relieve symptoms, but …

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Research Progress of Platinum-Based Complexes in Lung Cancer Treatment: Mechanisms, Applications, and Challenges

Wanqi Liang, Yufeng Huang, Yi Wang, Desheng Lu et autres

Platinum-based complexes, as one of the mainstay chemotherapeutic agents in oncology, have evolved from first-generation Cisplatin to third-generation Oxaliplatin, with numerous platinum complexes currently under clinical investigation. This review systematically evaluates all existing platinum complexes for lung cancer treatment, including three generations …

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CK1ε/SRSF10 axis regulates the alternative splicing of Bcl-x in lung cancer cells

Qi Sun, Yun Tang, Lian Wang, Boxin Liu et autres

The dysregulation of Bcl-x alternative splicing is associated with tumor development and chemoresistance. However, the underlying molecular mechanisms of Bcl-x splicing are still not well-defined. Here, we demonstrated that casein kinase 1ε (CK1ε) was involved in the regulation of Bcl-x alternative splicing. …

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Calcium Phosphate-Based Hydrogels Facilitate Biomineralization and Expedite Tissue Regeneration in Both Acute and Chronic Diabetic Wounds

Sapna Sayed, Mehdihassan Shekh, Qi Sun, Florian J. Stadler et autres

cn, tw, pk (code pays fourni par la source)

Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma

Feng Leng, Jiajia Huang, Liufeng Wu, Jianchao Zhang et autres

Breast cancer stem-like cells (CSCs) are enriched following treatment with chemotherapy, and posited as having a high level of plasticity and enhanced tumor-initiation capacity, which can enable cancer relapse. Here, we show that such features are shared by breast cancer (BCA) cells …

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Dialysis Modality Education Timing and Home Dialysis Uptake: A Quality Improvement Study

Desheng Lu, M Akhtar, Lisa Dubrofsky, Bourne Lewis Auguste

Rationale & Objective Investigating the effect of a quality improvement intervention aimed at enhancing the choice of home dialysis among patients through improved educational sessions on dialysis modalities. Study Design A new referral protocol initiated on September 15, 2022, sought to direct …

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Identification of energy metabolism anomalies and serum biomarkers in the progression of premature ovarian failure via extracellular vesicles’ proteomic and metabolomic profiles

Zhen Liu, Qi‐Lin Zhou, Liangge He, Zhengdong Liao et autres

BACKGROUND: Premature ovarian failure (POF) is a clinical condition characterized by the cessation of ovarian function, leading to infertility. The underlying molecular mechanisms remain unclear, and no predictable biomarkers have been identified. This study aimed to investigate the protein and metabolite contents …

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Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity

Linyuan Peng, Liang Zhou, Huan Li, Xin Zhang et autres

The major histocompatibility complex class I (MHC class I)-mediated tumor antigen processing and presentation (APP) pathway is essential for the recruitment and activation of cytotoxic CD8 + T lymphocytes (CD8 + CTLs). However, this pathway is frequently dysregulated in many cancers, thus …

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The CK 1ε/ SIAH1 axis regulates AXIN 1 stability in colorectal cancer cells

Mengfang Yan, Zijie Su, Xiaoyi Pang, Hanbin Wang et autres

Casein kinase 1ε (CK1ε) and axis inhibitor 1 (AXIN1) are crucial components of the β-catenin destruction complex in canonical Wnt signaling. CK1ε has been shown to interact with AXIN1, but its physiological function and role in tumorigenesis remain unknown. In this study, …

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