Zhien He

Elevated wzc Mutation Frequency Promotes Carbapenem Resistance Evolution in Hypervirulent Klebsiella pneumoniae ST23

Tao Chen, Xueting Wang, Luying Xiong, Zhuoqi Lou et autres

The worldwide expansion of carbapenemase-producing hypervirulent K. pneumoniae (CP-hvKP) raises serious concerns about potentially untreatable invasive infections. ST23, an archetypal hvKP clone, has been highlighted due to the rising prevalence of carbapenem resistance largely driven by horizontal plasmid transfer. However, the factors …

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Elevated wzc Mutation Frequency Promotes Carbapenem Resistance Evolution in Hypervirulent Klebsiella pneumoniae ST23

Tao Chen, Xueting Wang, Luying Xiong, Zhuoqi Lou et autres

The worldwide expansion of carbapenemase-producing hypervirulent K. pneumoniae (CP-hvKP) raises serious concerns about potentially untreatable invasive infections. ST23, an archetypal hvKP clone, has been highlighted due to the rising prevalence of carbapenem resistance largely driven by horizontal plasmid transfer. However, the factors …

Elevated wzc Mutation Frequency Promotes Carbapenem Resistance Evolution in Hypervirulent Klebsiella pneumoniae ST23

Tao Chen, Xueting Wang, Luying Xiong, Zhuoqi Lou et autres

The worldwide expansion of carbapenemase-producing hypervirulent K. pneumoniae (CP-hvKP) raises serious concerns about potentially untreatable invasive infections. ST23, an archetypal hvKP clone, has been highlighted due to the rising prevalence of carbapenem resistance largely driven by horizontal plasmid transfer. However, the factors …

Genomic Analysis of Hypervirulent Klebsiella pneumoniae ST1-KL122.

Yu Yang, Zhien He, Y Sophia Dai, Huaiwei Lu et autres

Background: . However, some clinically virulent isolates lack these canonical regulators, suggesting the existence of non-canonical pathways driving hypervirulence. Objective: . Materials and Methods: . Results: gene, which encodes a tyrosine kinase involved in capsular polysaccharide (CPS) export: c.1397A>C (p.Asn466Thr) and c.1721A>T …

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Staphylococcal accessory regulator SarA-mediated modulation of autolysis and surface charge enables Staphylococcus aureus to evade vancomycin killing

Yujie Li, Shihui Yuan, Ping Yan, Shupei Zhai et autres

ABSTRACT Staphylococcus aureus is a major source of community and nosocomial infections. Due to the extensive application of antibiotics, S. aureus has developed resistance to antibiotics, especially vancomycin, making clinical treatment challenging. Staphylococcal accessory regulator A (SarA) modulates S. aureus virulence by …

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Characterization and genomic analysis of the highly virulent Acinetobacter baumannii ST1791 strain dominating in Anhui, China

Zhien He, Yi Huang, Wei Ming Li, Huanhuan Zhang et autres

ABSTRACT The multidrug-resistant Acinetobacter baumannii clonal complex 92 is spreading worldwide due to its high-frequency gene mutation and recombination, posing a significant threat to global medical and health safety. Between November 2021 and April 2022, a total of 132 clinical A. baumannii …

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An induced mutation of ABC-transporter component VraF(K84E) contributes to vancomycin resistance and virulence in Staphylococcus aureus strain MW2

Ruobing Cao, Huimin Su, Zichun Wei, Zhien He et autres

Staphylococcus aureus is a notorious pathogen responsible for various severe diseases. Due to the emergence of drug-resistant strains, the prevention and treatment of S. aureus infections have become increasingly challenging. Vancomycin is considered to be one of the last-resort drugs for treating …

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Transposition mechanism of IS Apl1 —the determinant of colistin resistance dissemination

Wei Ming Li, Zhien He, Di Wei, Weifeng Xu et autres

ABSTRACT Multidrug-resistant Enterobacteriaceae , a prominent family of gram-negative pathogenic bacteria, causes a wide range of severe diseases. Strains carrying the mobile colistin resistance ( mcr-1 ) gene show resistance to polymyxin, the last line of defense against multidrug-resistant gram-negative bacteria. However, …

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Reductive behavior of nickel and iron metallization in magnesian siliceous nickel laterite ores under the action of sulfur-bearing natural gas

Zhien He, Bo Li, Yonggang Wei

Abstract This study is a process for the preparation of advanced nickel–iron alloys by selective reduction of nickel-poor laterite ores using a variety of reducing agents. The first part of the experiment was the reduction of nickel laterite ore using natural gas; …

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Prevalence of multidrug-resistant hypervirulent Klebsiella pneumoniae without defined hypervirulent biomarkers in Anhui, China: a new dimension of hypervirulence

Md Roushan Ali, Yang Yu, Yuanyuan Dai, Huaiwei Lu et autres

Klebsiella pneumoniae is an opportunistic pathogen that mainly causes nosocomial infections and hospital-associated pneumonia in elderly and immunocompromised people. However, multidrug-resistant hypervirulent K. pneumoniae (MDR-hvKp) has emerged recently as a serious threat to global health that can infect both immunocompromised and healthy …

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Epidemiological characteristics of multidrug-resistant Acinetobacter baumannii ST369 in Anhui, China

Yi Huang, Md Roushan Ali, Wei Ming Li, Wanying Wang et autres

ABSTRACT Acinetobacter baumannii is of growing concern for global health owing to its ability to evade the immune system and develop resistance to antibiotics. We analyzed A. baumannii using the National Center for Biotechnology Information ( https://www.ncbi.nlm.nih.gov/pathogens ) database and observed that …

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Corrigendum: Epidemiological characteristics an outbreak of ST11 multidrug-resistant and hypervirulent Klebsiella pneumoniae in Anhui, China

Zhien He, Weifeng Xu, Hang Zhao, Wei Ming Li et autres

In the published article, there was an error in affiliations [1,2]. Instead of “[1Department of Oncology, The First Affiliated Hospital, University of Science and Technology of China, Hefei, China, 2School of Life Sciences and Medicine, University of Science and Technology of China, …

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